Protein: MINT
Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)

Gene: MINT, SPEN
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q96T58

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003714 - transcription corepressor activity
GO:0003723 - RNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1335373

CAMKV
CaM kinase-like vesicle-associated protein

3

5

High-throughput

0.765

High

1132916

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

16

High-throughput

0.754

High

1054774

SUH
Recombining binding protein suppressor of hairless

7

2

Small-scale

0.748

High

1096481

PAK1
Serine/threonine-protein kinase PAK 1

1

6

Small-scale

0.725

High

1099491

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

666894

CCNC
Cyclin-C

4

9

High-throughput

0.683

High

1403528

NCOR2
Nuclear receptor corepressor 2

3

8

Small-scale

0.682

High

889489

CLK1
Dual specificity protein kinase CLK1

1

20

High-throughput

0.647

High

1006645

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.647

High

404360

GCR
Glucocorticoid receptor

3

20

Small-scale

0.640

High

785386

RL4
Large ribosomal subunit protein uL4

3

5

High-throughput

0.640

High

872006

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

1

High-throughput

0.628

High

1403521

DAXX
Death domain-associated protein 6

2

1

High-throughput

0.628

High

897371

CDK7
Cyclin-dependent kinase 7

1

7

High-throughput

0.618

High

911658

NCBP2
Nuclear cap-binding protein subunit 2

1

19

High-throughput

0.618

High

872662

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.611

High

1290668

ZCH18
Zinc finger CCCH domain-containing protein 18

2

14

High-throughput

0.611

High

1403519

WRP73
WD repeat-containing protein WRAP73

3

13

High-throughput

0.609

High

855735

CRK
Adapter molecule crk

2

12

High-throughput

0.595

High

372922

MYC
Myc proto-oncogene protein

2

19

High-throughput

0.584

High

998716

H31
Histone H3.1

2

10

High-throughput

0.584

High

1017146

H33
Histone H3.3

2

10

High-throughput

0.584

High

1330512

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

6

High-throughput

0.574

High

168561

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

2

Small-scale

0.573

High

396770

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1103334

CTBP1
C-terminal-binding protein 1

1

7

Small-scale

0.561

High

1110015

HDAC1
Histone deacetylase 1

1

15

Small-scale

0.561

High

1403524

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.554

High

1055262

MTG8
Protein CBFA2T1

1

4

Small-scale

0.552

High

1397284

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

0

Small-scale

0.549

High

1403509

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.537

High

1403511

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.537

High

272736

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

12

High-throughput

0.536

High

336757

BAG4
BAG family molecular chaperone regulator 4

1

4

High-throughput

0.536

High

537758

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.536

High

854245

KI67
Proliferation marker protein Ki-67

1

9

High-throughput

0.536

High

931074

HSP72
Heat shock-related 70 kDa protein 2

1

9

High-throughput

0.536

High

1123087

FHL2
Four and a half LIM domains protein 2

1

5

High-throughput

0.536

High

1289392

URP2
Fermitin family homolog 3

1

1

High-throughput

0.536

High

1403518

BCLF1
Bcl-2-associated transcription factor 1

1

9

High-throughput

0.536

High

1403520

IKBL1
NF-kappa-B inhibitor-like protein 1

1

1

High-throughput

0.536

High

601823

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.515

High

985298

RL10A
Large ribosomal subunit protein uL1

1

4

High-throughput

0.515

High

1403525

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

927510

ATX1
Ataxin-1

1

8

High-throughput

0.508

High

278411

NCOR1
Nuclear receptor corepressor 1

1

13

Small-scale

0.501

High

1394592

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

9

High-throughput

0.501

High

347271

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

1311020

SULF2
Extracellular sulfatase Sulf-2

1

3

High-throughput

0.489

High

1324482

AN36B
Ankyrin repeat domain-containing protein 36B

1

11

High-throughput

0.489

High

1325077

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

2

High-throughput

0.489

High

1384113

ARRD3
Arrestin domain-containing protein 3

1

7

High-throughput

0.489

High

1402694

TCPQM
T-complex protein 1 subunit theta-like 2

1

4

High-throughput

0.489

High

129356

MEN1
Menin

1

6

High-throughput

0.479

High

130589

SPT5H
Transcription elongation factor SPT5

1

10

High-throughput

0.479

High

181554

TBXT
T-box transcription factor T

1

9

High-throughput

0.479

High

210099

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

223273

PRC1
Protein regulator of cytokinesis 1

1

8

High-throughput

0.479

High

285428

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

323547

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

334082

SMC2
Structural maintenance of chromosomes protein 2

1

5

High-throughput

0.479

High

339833

KLF8
Krueppel-like factor 8

1

18

High-throughput

0.479

High

346223

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

18

High-throughput

0.479

High

363748

EGFR
Epidermal growth factor receptor

1

12

High-throughput

0.479

High

414467

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

468721

HS90B
Heat shock protein HSP 90-beta

1

6

High-throughput

0.479

High

487663

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.479

High

558352

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

589484

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

594085

NCK1
SH2/SH3 adapter protein NCK1

1

18

High-throughput

0.479

High

696294

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

699836

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

High-throughput

0.479

High

765820

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.479

High

768968

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

778096

VGFR2
Vascular endothelial growth factor receptor 2

1

3

High-throughput

0.479

High

834038

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

862397

YAP1
Transcriptional coactivator YAP1

1

17

High-throughput

0.479

High

887152

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.479

High

887459

CEBPD
CCAAT/enhancer-binding protein delta

1

20

Small-scale

0.479

High

905061

MECP2
Methyl-CpG-binding protein 2

1

9

High-throughput

0.479

High

980189

H4
Histone H4

1

8

High-throughput

0.479

High

981034

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

981658

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

987883

GRB2
Growth factor receptor-bound protein 2

1

15

High-throughput

0.479

High

1041794

PPARD
Peroxisome proliferator-activated receptor delta

1

20

Small-scale

0.479

High

1048072

TLE3
Transducin-like enhancer protein 3

1

17

High-throughput

0.479

High

1097514

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

1107125

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1128094

DHX8
ATP-dependent RNA helicase DHX8

1

9

High-throughput

0.479

High

1133624

NFIX
Nuclear factor 1 X-type

1

19

High-throughput

0.479

High

1145511

RBBP5
Retinoblastoma-binding protein 5

1

18

High-throughput

0.479

High

1155687

EZH2
Histone-lysine N-methyltransferase EZH2

1

11

High-throughput

0.479

High

1158970

RBBP7
Histone-binding protein RBBP7

1

16

High-throughput

0.479

High

1235502

IFIX
Pyrin and HIN domain-containing protein 1

1

7

High-throughput

0.479

High

1271207

DPPA4
Developmental pluripotency-associated protein 4

1

3

High-throughput

0.479

High

1276683

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1279299

I2BP2
Interferon regulatory factor 2-binding protein 2

1

9

Small-scale

0.479

High

1287007

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

7

Small-scale

0.479

High

1313364

SMC5
Structural maintenance of chromosomes protein 5

1

13

High-throughput

0.479

High

1338917

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1357529

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.479

High

1364217

TOPB1
DNA topoisomerase 2-binding protein 1

1

10

High-throughput

0.479

High

1382824

FUBP1
Far upstream element-binding protein 1

1

20

High-throughput

0.479

High

1387512

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

18

High-throughput

0.479

High

1403512

ANLN
Anillin

1

9

High-throughput

0.479

High

1403513

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

1403514

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

1403515

NLE1
Notchless protein homolog 1

1

10

High-throughput

0.479

High

1403516

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

4

High-throughput

0.479

High

1403517

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1403523

NUP50
Nuclear pore complex protein Nup50

1

4

High-throughput

0.479

High

1403526

ASF1A
Histone chaperone ASF1A

1

2

High-throughput

0.479

High

914035

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

0

High-throughput

0.460

High

1403522

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.460

High

189791

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

660146

COF1
Cofilin-1

1

0

High-throughput

0.458

High

1149831

TAF11
Transcription initiation factor TFIID subunit 11

1

0

High-throughput

0.458

High

95754

E5RFK5
Cyclin-C

1

9

High-throughput

0.445

High

832777

BCL6
B-cell lymphoma 6 protein

1

4

Small-scale

0.445

High

1130400

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

8

High-throughput

0.445

High

1403508

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.445

High

1403510

E41L5
Band 4.1-like protein 5

1

16

High-throughput

0.445

High

1403527

LC7L2
Putative RNA-binding protein Luc7-like 2

1

8

High-throughput

0.445

High

272404

OBSL1
Obscurin-like protein 1

1

9

High-throughput

0.437

High

318861

RHBT1
Rho-related BTB domain-containing protein 1

1

13

High-throughput

0.437

High

619095

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

High-throughput

0.437

High

885012

DGKG
Diacylglycerol kinase gamma

1

1

High-throughput

0.437

High

991916

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.437

High

1071184

ARL16
ADP-ribosylation factor-like protein 16

1

5

High-throughput

0.437

High

1135056

CUL7
Cullin-7

1

9

High-throughput

0.437

High

1029916

RUNX1
Runt-related transcription factor 1

1

6

Small-scale

0.408

High

516120

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

1403529

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

297253

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.249

Low

1025946

NDP
Norrin

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025