HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	33961781, 35271311, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1257
+	Hs
		151857 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		151689 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		151692 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		151716 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		129219 P85B_HUMAN (1-728): 0: 549: 100.00		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Hs
		1267462 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82
+	Hs
		724554 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Rn
		139726 P85A_RAT (476-721): 2.91e-21: 100: 18.55		O08724_RAT (59-334): 3.27e-80: 274: 35.93
+	Dm
		186292 O18683_DROME (319-488): 8.23e-19: 92.2: 21.64		IRS1_DROME (83-354): 1.31e-71: 261: 30.00
+	Mm
		639440 LYN_MOUSE (556-724): 1.96e-29: 125: 20.90		IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68
+	Hs
		412057 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Rn
		94391 P85A_RAT (476-721): 2.91e-21: 100: 18.55		F1MAL5_RAT (601-1085): 2.45e-23: 109: 22.37
+	Mm
		643075 P85A_MOUSE (606-721): 1.27e-20: 98.9: 28.81		IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68
+	Hs
		655516 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82
+	Hs
		655240 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Rn
		94388 GRB2_RAT (329-411): 1.45e-14: 75.2: 31.40		F1MAL5_RAT (601-1085): 2.45e-23: 109: 22.37
+	Rn
		724634 P85A_RAT (476-721): 2.91e-21: 100: 18.55		IRS1_RAT (685-1099): 3.05e-15: 83.3: 19.47
+	Mm
		643063 P85A_MOUSE (606-721): 1.27e-20: 98.9: 28.81		IRS1_MOUSE (685-1099): 2.43e-15: 83.7: 18.51
+	Mm
		724599 GRB2_MOUSE (329-411): 1.49e-14: 75.2: 31.40		IRS1_MOUSE (685-1099): 2.43e-15: 83.7: 18.51
+	Rn
		724631 GRB2_RAT (329-411): 1.45e-14: 75.2: 31.40		IRS1_RAT (685-1099): 3.05e-15: 83.3: 19.47