HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 864
+	Hs
		129350 P85B_HUMAN (1-728): 0: 549: 100.00		ALK_HUMAN (4-851): 0: 701: 54.51
+	Hs
		129170 P85B_HUMAN (1-728): 0: 549: 100.00		RET_HUMAN (278-849): 5.71e-146: 461: 25.98
+	Hs
		129198 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA1_HUMAN (25-817): 9.44e-137: 433: 19.11
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (163-833): 6.48e-137: 429: 20.03
+	Hs
		129295 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB4_HUMAN (277-847): 5.2e-131: 425: 21.37
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (391-796): 1.67e-127: 410: 26.21
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (388-798): 3.64e-124: 400: 27.30
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (389-809): 8.73e-124: 400: 26.02
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (391-827): 1.68e-110: 369: 34.69
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (446-813): 2.21e-109: 360: 30.38
+	Hs
		129300 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK2_HUMAN (475-778): 2.43e-61: 224: 38.07
+	Hs
		129160 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64
+	Hs
		129232 P85B_HUMAN (1-728): 0: 549: 100.00		TEC_HUMAN (504-777): 1.34e-56: 207: 41.52
+	Hs
		129299 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK3_HUMAN (502-778): 1.77e-54: 205: 36.76
+	Hs
		129278 P85B_HUMAN (1-728): 0: 549: 100.00		ROR1_HUMAN (504-778): 1.86e-53: 202: 40.00
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39
+	Hs
		385265 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64