HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 512
+	Hs
		129173 P85B_HUMAN (1-728): 0: 549: 100.00		HCK_HUMAN (1-512): 0: 595: 70.70
+	Hs
		129163 P85B_HUMAN (1-728): 0: 549: 100.00		LCK_HUMAN (1-512): 0: 582: 63.62
+	Hs
		129185 P85B_HUMAN (1-728): 0: 549: 100.00		SRC_HUMAN (1-510): 0: 580: 51.97
+	Hs
		129164 P85B_HUMAN (1-728): 0: 549: 100.00		FYN_HUMAN (1-510): 0: 576: 54.12
+	Hs
		129151 P85B_HUMAN (1-728): 0: 549: 100.00		ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88
+	Hs
		69198 P85B_HUMAN (1-728): 0: 549: 100.00		A9UF07_HUMAN (38-509): 3.95e-165: 512: 38.14
+	Hs
		129232 P85B_HUMAN (1-728): 0: 549: 100.00		TEC_HUMAN (35-505): 1.09e-160: 472: 35.48
+	Hs
		433926 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		LYN_HUMAN (1-512): 0: 611: 100.00
+	Hs
		442864 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		HCK_HUMAN (1-512): 0: 595: 70.70
+	Hs
		523089 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		SRC_HUMAN (1-510): 0: 580: 51.97
+	Hs
		412285 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FYN_HUMAN (1-510): 0: 576: 54.12
+	Hs
		433433 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		YES_HUMAN (1-510): 0: 572: 54.26
+	Hs
		846504 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		BLK_HUMAN (1-512): 0: 544: 60.00
+	Hs
		789082 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61
+	Hs
		986388 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		BTK_HUMAN (2-505): 1.48e-156: 462: 33.86
+	Hs
		412098 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		FYN_HUMAN (1-510): 0: 576: 54.12
+	Dm
		1360389 SRC42_DROME (551-727): 1.47e-35: 143: 22.78		SRC42_DROME (2-510): 0: 560: 49.13
+	Dm
		337641 ABL_DROME (531-725): 1.27e-32: 138: 20.92		ABL_DROME (3-508): 3.3e-170: 523: 36.36
+	Dm
		337668 SRC64_DROME (550-722): 2.59e-33: 137: 18.23		SRC64_DROME (20-510): 3.4e-178: 513: 43.91
+	Dm
		337669 SRC64_DROME (550-722): 2.59e-33: 137: 18.23		BTKL_DROME (16-497): 2.58e-158: 471: 38.04