HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0019903 - protein phosphatase binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1390
+	Hs
		441546 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		441461 TXK_HUMAN (550-727): 8.04e-33: 135: 23.24		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91
+	Hs
		129297 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15
+	Hs
		872468 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08
+	Hs
		129215 P85B_HUMAN (1-728): 0: 549: 100.00		UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90
+	Mm
		140060 P85B_MOUSE (1-728): 0: 541: 88.87		UFO_MOUSE (1078-1333): 3.39e-65: 241: 46.27
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (1056-1337): 6.24e-54: 209: 39.67
+	Hs
		129295 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		129151 P85B_HUMAN (1-728): 0: 549: 100.00		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38
+	Hs
		674489 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		1070991 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		561399 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FER_HUMAN (1078-1340): 5.99e-52: 199: 37.36