HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: BCR (P11274)
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene: BCR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGAP~RhoGAP, C2~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1271
+	Hs
		337325 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		BCR_HUMAN (1-1271): 0: 1005: 100.00
+	Hs
		506538 FRK_HUMAN (545-724): 2.43e-31: 130: 22.46		BCR_HUMAN (1-1271): 0: 1005: 100.00
+	Hs
		442768 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		BCR_HUMAN (1-1271): 0: 1005: 100.00
+	Hs
		337453 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		ABR_HUMAN (419-1271): 0: 567: 66.47
+	Hs
		69198 P85B_HUMAN (1-728): 0: 549: 100.00		A9UF07_HUMAN (690-1072): 3.04e-27: 122: 60.83
+	Hs
		411673 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		FGD1_HUMAN (162-971): 1.22e-77: 279: 13.57
+	Hs
		411981 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		548690 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		337333 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		411580 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		548654 TEC_HUMAN (392-727): 6.13e-31: 130: 14.80		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		412357 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		ECT2_HUMAN (335-923): 3.96e-71: 259: 17.07
+	Hs
		299230 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		FARP2_HUMAN (356-812): 1.08e-68: 253: 18.26
+	Hs
		224699 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		KALRN_HUMAN (457-1087): 1.21e-57: 222: 14.20
+	Hs
		224698 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		KALRN_HUMAN (457-1087): 1.21e-57: 222: 14.20
+	Hs
		279830 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		TRIO_HUMAN (482-1040): 8.74e-54: 209: 12.72
+	Hs
		279832 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		TRIO_HUMAN (482-1040): 8.74e-54: 209: 12.72
+	Ce
		220207 SRC2_CAEEL (550-726): 8.48e-34: 138: 21.11		TG325_CAEEL (1039-1212): 9.19e-24: 110: 37.93
+	Hs
		411755 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		RHG21_HUMAN (1049-1216): 3.06e-23: 109: 40.00
+	Hs
		442834 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		RBP1_HUMAN (1051-1211): 4.99e-20: 98.2: 34.55