Protein: TIA1
Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1 isoform p40) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1)

Gene: TIA1
Organism: Homo sapiens
Interactions: 118
UniProt ID: P31483

Gene Ontology (top 5):
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0001818 - negative regulation of cytokine production
GO:0003723 - RNA binding
GO:0003730 - mRNA 3'-UTR binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

726752

TIAR
Nucleolysin TIAR

3

14

Small-scale

0.839

High

726768

ELAV1
ELAV-like protein 1

2

15

Small-scale

0.776

High

726758

G3BP1
Ras GTPase-activating protein-binding protein 1

2

12

Small-scale

0.754

High

477926

SNRPA
U1 small nuclear ribonucleoprotein A

1

19

Small-scale

0.665

High

726735

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

14

Small-scale

0.665

High

726763

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

17

Small-scale

0.665

High

215259

TXNL1
Thioredoxin-like protein 1

1

2

High-throughput

0.618

High

472472

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

17

Small-scale

0.618

High

550137

PABP1
Polyadenylate-binding protein 1

1

14

Small-scale

0.618

High

726750

SRSF3
Serine/arginine-rich splicing factor 3

1

17

Small-scale

0.618

High

726754

EWS
RNA-binding protein EWS

1

10

High-throughput

0.618

High

726778

RAVR1
Ribonucleoprotein PTB-binding 1

1

17

High-throughput

0.618

High

726804

RC3H2
Roquin-2

1

9

High-throughput

0.618

High

726810

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.618

High

726767

SF01
Splicing factor 1

1

6

High-throughput

0.590

High

529183

TAU
Microtubule-associated protein tau

2

7

Small-scale

0.586

High

344105

PTBP3
Polypyrimidine tract-binding protein 3

1

13

High-throughput

0.575

High

480040

RU1C
U1 small nuclear ribonucleoprotein C

1

2

Small-scale

0.561

High

726751

CYC
Cytochrome c

2

0

Small-scale

0.559

High

286430

WBP4
WW domain-binding protein 4

1

5

Small-scale

0.541

High

726765

FASTK
Fas-activated serine/threonine kinase

1

0

Small-scale

0.537

High

417278

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.536

High

698423

CALX
Calnexin

1

1

High-throughput

0.536

High

726739

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.536

High

726742

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.536

High

726759

CUL1
Cullin-1

1

20

High-throughput

0.536

High

726760

CUL2
Cullin-2

1

20

High-throughput

0.536

High

726761

CUL3
Cullin-3

1

20

High-throughput

0.536

High

726762

CUL4A
Cullin-4A

1

20

High-throughput

0.536

High

726776

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

High-throughput

0.536

High

726777

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

726786

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.536

High

726787

CUL5
Cullin-5

1

20

High-throughput

0.536

High

726791

DCNL1
DCN1-like protein 1

1

3

High-throughput

0.536

High

619538

VCAM1
Vascular cell adhesion protein 1

2

7

High-throughput

0.521

High

726757

ILF3
Interleukin enhancer-binding factor 3

1

7

Small-scale

0.515

High

726748

TM258
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

1

0

High-throughput

0.513

High

726749

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

726772

RICTR
Rapamycin-insensitive companion of mTOR

1

0

Small-scale

0.513

High

726788

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

417967

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.489

High

726741

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.489

High

726782

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.489

High

726798

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

1

High-throughput

0.489

High

117162

J9JIF5
CXXC-type zinc finger protein 4

1

2

High-throughput

0.479

High

125264

LEG9
Galectin-9

1

2

High-throughput

0.479

High

128800

MEN1
Menin

1

3

High-throughput

0.479

High

137315

ELL2
RNA polymerase II elongation factor ELL2

1

2

High-throughput

0.479

High

142859

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

240864

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

335013

ARI2
E3 ubiquitin-protein ligase ARIH2

1

10

High-throughput

0.479

High

352335

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

365744

KAD1
Adenylate kinase isoenzyme 1

1

1

High-throughput

0.479

High

371279

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

395570

ESR1
Estrogen receptor

1

15

Small-scale

0.479

High

405829

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

443680

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

1

Small-scale

0.479

High

483882

HMOX1
Heme oxygenase 1

1

1

Small-scale

0.479

High

563282

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

Small-scale

0.479

High

627927

ANXA7
Annexin A7

1

1

Small-scale

0.479

High

629544

CD22
B-cell receptor CD22

1

7

Small-scale

0.479

High

703911

DUS1
Dual specificity protein phosphatase 1

1

4

Small-scale

0.479

High

726736

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.479

High

726737

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

726744

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.479

High

726745

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.479

High

726753

OTUD4
OTU domain-containing protein 4

1

5

High-throughput

0.479

High

726755

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

726766

R3HD1
R3H domain-containing protein 1

1

7

High-throughput

0.479

High

726769

SMN
Survival motor neuron protein

1

1

High-throughput

0.479

High

726771

RBM20
RNA-binding protein 20

1

5

High-throughput

0.479

High

726773

BCOR
BCL-6 corepressor

1

2

High-throughput

0.479

High

726774

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

726783

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

726784

ESR2
Estrogen receptor beta

1

15

High-throughput

0.479

High

726785

RENT1
Regulator of nonsense transcripts 1

1

8

High-throughput

0.479

High

726789

KCD12
BTB/POZ domain-containing protein KCTD12

1

2

High-throughput

0.479

High

726790

RBM33
RNA-binding protein 33

1

5

High-throughput

0.479

High

726792

FUBP3
Far upstream element-binding protein 3

1

20

High-throughput

0.479

High

726793

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

726794

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.479

High

726795

TRI31
E3 ubiquitin-protein ligase TRIM31

1

12

High-throughput

0.479

High

726801

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.479

High

726803

NANOG
Homeobox protein NANOG

1

4

High-throughput

0.479

High

726808

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.479

High

726809

POLK
DNA polymerase kappa

1

1

High-throughput

0.479

High

726811

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

726812

DDX20
Probable ATP-dependent RNA helicase DDX20

1

17

High-throughput

0.479

High

726813

KDIS
Kinase D-interacting substrate of 220 kDa

1

1

High-throughput

0.479

High

337563

FMNL1
Formin-like protein 1

1

0

Small-scale

0.458

High

443008

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

Small-scale

0.458

High

726746

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

726770

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

726775

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

726806

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

327820

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

18

High-throughput

0.445

High

726740

RS9
Small ribosomal subunit protein uS4

1

2

Small-scale

0.445

High

726743

TOB1
Protein Tob1

1

3

Small-scale

0.445

High

726747

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

18

High-throughput

0.445

High

726756

TAGL
Transgelin

1

1

High-throughput

0.445

High

726796

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

18

High-throughput

0.445

High

726797

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

18

High-throughput

0.445

High

726799

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

18

High-throughput

0.445

High

389077

FINC
Fibronectin

1

6

High-throughput

0.437

High

411441

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

565177

ITA4
Integrin alpha-4

1

4

High-throughput

0.437

High

726780

NETO2
Neuropilin and tolloid-like protein 2

1

1

High-throughput

0.437

High

726781

TIP
T-cell immunomodulatory protein

1

2

High-throughput

0.437

High

726802

GORS2
Golgi reassembly-stacking protein 2

1

2

High-throughput

0.437

High

726805

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

7

High-throughput

0.437

High

397906

ANGI
Angiogenin

1

0

High-throughput

0.426

High

505134

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

726738

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

726764

MLEC
Malectin

1

0

High-throughput

0.279

Low

726779

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

726807

OSTC
Oligosaccharyltransferase complex subunit OSTC

1

0

High-throughput

0.279

Low

726800

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025