HitPredict

Interactor 1: SMRD1 (Q96GM5)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit)
Gene: SMARCD1

Interactor 2: NR1H4 (Q96RI1)
Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
Gene: NR1H4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	12917342
Identification Methods	pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0071398 - cellular response to fatty acid
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 515 Hs			1 486
+	Hs
		1164506 SMRD3_HUMAN (60-515): 0: 613: 74.35		NR1H4_HUMAN (1-486): 6.66e-163: 471: 100.00
+	Hs
		370197 SMRD1_HUMAN (1-515): 0: 696: 100.00		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Mm
		1142593 SMRD1_MOUSE (1-515): 0: 696: 99.42		ERR2_MOUSE (37-485): 5.61e-105: 321: 21.59
+	Hs
		740582 SMRD1_HUMAN (1-515): 0: 696: 100.00		PPARG_HUMAN (48-483): 3.41e-102: 317: 26.32
+	Hs
		611490 SMRD1_HUMAN (1-515): 0: 696: 100.00		NR4A1_HUMAN (14-483): 1.12e-100: 316: 22.45
+	Hs
		782629 SMRD1_HUMAN (1-515): 0: 696: 100.00		HNF4A_HUMAN (113-483): 6.35e-100: 309: 23.14
+	Hs
		1269351 SMRD1_HUMAN (1-515): 0: 696: 100.00		ESR2_HUMAN (35-486): 2.01e-98: 307: 21.15
+	Hs
		369849 SMRD3_HUMAN (60-515): 0: 613: 74.35		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Hs
		587184 SMRD3_HUMAN (60-515): 0: 613: 74.35		RXRA_HUMAN (11-485): 4.19e-119: 358: 20.78
+	Hs
		370147 SMRD2_HUMAN (51-515): 0: 601: 66.39		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Hs
		500368 SMRD3_HUMAN (60-515): 0: 613: 74.35		RARB_HUMAN (38-484): 9.82e-104: 319: 27.31
+	Mm
		509322 SMRD3_MOUSE (60-515): 0: 613: 74.35		RARA_MOUSE (37-484): 1.71e-103: 318: 25.83
+	Hs
		487986 SMRD3_HUMAN (60-515): 0: 613: 74.35		RARA_HUMAN (37-484): 3.76e-103: 317: 25.61
+	Hs
		740544 SMRD3_HUMAN (60-515): 0: 613: 74.35		PPARG_HUMAN (48-483): 3.41e-102: 317: 26.32
+	Hs
		611457 SMRD3_HUMAN (60-515): 0: 613: 74.35		NR4A1_HUMAN (14-483): 1.12e-100: 316: 22.45
+	Hs
		782575 SMRD3_HUMAN (60-515): 0: 613: 74.35		HNF4A_HUMAN (113-483): 6.35e-100: 309: 23.14
+	Hs
		611483 SMRD2_HUMAN (51-515): 0: 601: 66.39		NR4A1_HUMAN (14-483): 1.12e-100: 316: 22.45
+	Hs
		530800 SMRD3_HUMAN (60-515): 0: 613: 74.35		RARG_HUMAN (53-484): 7e-97: 301: 27.23
+	Hs
		782617 SMRD2_HUMAN (51-515): 0: 601: 66.39		HNF4A_HUMAN (113-483): 6.35e-100: 309: 23.14
+	Hs
		1269285 SMRD2_HUMAN (51-515): 0: 601: 66.39		ESR2_HUMAN (35-486): 2.01e-98: 307: 21.15