HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0051492 - regulation of stress fiber assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 191
+	Hs
		129193 P85B_HUMAN (1-728): 0: 549: 100.00		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		129334 P85B_HUMAN (1-728): 0: 549: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		129270 P85B_HUMAN (1-728): 0: 549: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		129275 P85B_HUMAN (1-728): 0: 549: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		129262 P85B_HUMAN (1-728): 0: 549: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		129190 P85B_HUMAN (1-728): 0: 549: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		129259 P85B_HUMAN (1-728): 0: 549: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		129312 P85B_HUMAN (1-728): 0: 549: 100.00		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		564631 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		900751 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		564442 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		789092 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		855782 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		789055 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		855778 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		789051 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		855779 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545245 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		411948 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		789050 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32