HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 245
+	Hs
		129265 P85B_HUMAN (1-728): 0: 549: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		129204 P85B_HUMAN (1-728): 0: 549: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Mm
		140059 P85B_MOUSE (1-728): 0: 541: 88.87		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Hs
		129216 P85B_HUMAN (1-728): 0: 549: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		789056 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		337420 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		789053 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		337416 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646706 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		337355 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		411605 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683185 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		337366 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		789052 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		337415 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		789060 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		337436 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		683884 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		683983 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		337367 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97