HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	25253337
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 904
+	Hs
		411698 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Hs
		433731 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Mm
		411930 LCK_MOUSE (547-724): 1.39e-30: 128: 23.12		DLG1_MOUSE (1-904): 0: 720: 95.47
+	Hs
		655344 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Hs
		434043 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		PALS2_HUMAN (421-899): 2.36e-108: 346: 23.48
+	Hs
		159139 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		CSKP_HUMAN (19-360): 4.23e-28: 124: 10.64
+	Hs
		159138 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		CSKP_HUMAN (19-360): 4.23e-28: 124: 10.64
+	Hs
		412128 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Hs
		411718 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49
+	Hs
		433758 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49
+	Mm
		403445 SRC_MOUSE (535-728): 1.19e-28: 122: 18.81		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Hs
		411800 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		DLG5_HUMAN (202-404): 4.58e-19: 95.5: 32.02
+	Rn
		73322 SRC_RAT (535-728): 8.09e-29: 123: 18.81		PALS1_RAT (1-397): 5.96e-21: 100: 14.74
+	Hs
		433909 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		DLG5_HUMAN (202-404): 4.58e-19: 95.5: 32.02
+	Hs
		411753 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		MPP7_HUMAN (96-459): 7.98e-17: 86.8: 14.80
+	Hs
		433812 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		MPP7_HUMAN (96-459): 7.98e-17: 86.8: 14.80
+	Hs
		433697 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		EM55_HUMAN (161-314): 1.14e-14: 79.5: 14.56
+	Hs
		522978 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		MPP2_HUMAN (134-320): 5.48e-13: 74.9: 16.84
+	Mm
		1141133 GRB2_MOUSE (329-411): 1.49e-14: 75.2: 31.40		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Hs
		782833 CSK_HUMAN (324-446): 1.13e-24: 109: 26.02		ZO2_HUMAN (435-711): 1.38e-13: 77.2: 17.13