Protein: NOP58
Nucleolar protein 58 (Nucleolar protein 5)

Gene: NOP58
Organism: Homo sapiens
Interactions: 241
UniProt ID: Q9Y2X3

Gene Ontology (top 5):
GO:0001094 - TFIID-class transcription factor complex binding
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

644143

FBRL
rRNA 2'-O-methyltransferase fibrillarin

11

8

Small-scale

0.976

High

141176

NOP56
Nucleolar protein 56

5

9

Small-scale

0.919

High

1454368

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

2

2

Small-scale

0.806

High

938425

NH2L1
NHP2-like protein 1

2

9

High-throughput

0.802

High

1490454

RUVB2
RuvB-like 2

5

8

Small-scale

0.712

High

1490517

RUVB1
RuvB-like 1

4

8

Small-scale

0.683

High

373558

MYC
Myc proto-oncogene protein

4

4

High-throughput

0.676

High

1459991

NUFP1
FMR1-interacting protein NUFIP1

3

2

Small-scale

0.657

High

1401850

TGS1
Trimethylguanosine synthase

2

1

Small-scale

0.639

High

228765

U3IP2
U3 small nucleolar RNA-interacting protein 2

2

11

High-throughput

0.628

High

911439

IMA5
Importin subunit alpha-5

2

13

High-throughput

0.628

High

998124

CSK21
Casein kinase II subunit alpha

2

2

Small-scale

0.625

High

1114708

CUL3
Cullin-3

2

3

High-throughput

0.611

High

1151337

ZNHI3
Zinc finger HIT domain-containing protein 3

2

1

Small-scale

0.611

High

1438954

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

2

2

High-throughput

0.611

High

993824

UBC9
SUMO-conjugating enzyme UBC9

2

2

Small-scale

0.602

High

831681

CCNF
Cyclin-F

2

2

High-throughput

0.601

High

1451215

BCD1
Box C/D snoRNA protein 1

2

1

Small-scale

0.601

High

1451329

PIHD1
PIH1 domain-containing protein 1

2

2

Small-scale

0.601

High

243348

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

260637

BRD4
Bromodomain-containing protein 4

2

11

High-throughput

0.584

High

272566

OBSL1
Obscurin-like protein 1

2

3

High-throughput

0.584

High

346532

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

4

High-throughput

0.584

High

872915

SOX2
Transcription factor SOX-2

2

6

High-throughput

0.584

High

980575

H4
Histone H4

2

2

High-throughput

0.584

High

1100565

TIF1B
Transcription intermediary factor 1-beta

2

5

Small-scale

0.584

High

1133064

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

9

High-throughput

0.584

High

1155931

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

High-throughput

0.584

High

1194475

LARP7
La-related protein 7

2

11

High-throughput

0.584

High

1393847

DDRGK
DDRGK domain-containing protein 1

2

2

Small-scale

0.584

High

1447473

ANLN
Anillin

2

3

High-throughput

0.584

High

1038382

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

1

High-throughput

0.571

High

1398416

CEP63
Centrosomal protein of 63 kDa

2

5

Small-scale

0.571

High

1461292

VAV3
Guanine nucleotide exchange factor VAV3

2

3

High-throughput

0.571

High

1448255

SIR7
NAD-dependent protein deacetylase sirtuin-7

2

0

Small-scale

0.559

High

253705

IMA7
Importin subunit alpha-7

1

13

High-throughput

0.536

High

431282

LA
Lupus La protein

1

7

High-throughput

0.536

High

471335

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.536

High

634704

LMNB1
Lamin-B1

1

3

High-throughput

0.536

High

641070

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

3

High-throughput

0.536

High

694080

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.536

High

788274

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.536

High

833225

MNDA
Myeloid cell nuclear differentiation antigen

1

4

High-throughput

0.536

High

854394

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

890421

NU153
Nuclear pore complex protein Nup153

1

4

High-throughput

0.536

High

911164

IMA1
Importin subunit alpha-1

1

14

High-throughput

0.536

High

940578

AP1S2
AP-1 complex subunit sigma-2

1

2

High-throughput

0.536

High

1027864

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.536

High

1116158

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.536

High

1120519

SCRB2
Lysosome membrane protein 2

1

1

High-throughput

0.536

High

1134440

IMB1
Importin subunit beta-1

1

2

High-throughput

0.536

High

1161769

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.536

High

1250697

BCOR
BCL-6 corepressor

1

4

Small-scale

0.536

High

1270681

COX15
Heme A synthase COX15

1

3

High-throughput

0.536

High

1291296

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.536

High

1316649

CDK20
Cyclin-dependent kinase 20

1

2

High-throughput

0.536

High

1406666

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.536

High

1435198

RPAP3
RNA polymerase II-associated protein 3

1

7

High-throughput

0.536

High

1447868

DDX21
Nucleolar RNA helicase 2

1

3

Small-scale

0.536

High

1490980

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

1

High-throughput

0.536

High

1436830

WDR76
WD repeat-containing protein 76

2

10

High-throughput

0.533

High

1452067

MCM9
DNA helicase MCM9

2

2

Small-scale

0.533

High

1253758

RHG36
Rho GTPase-activating protein 36

2

1

High-throughput

0.521

High

1431205

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

2

5

High-throughput

0.521

High

766035

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.515

High

895679

SERPH
Serpin H1

1

1

High-throughput

0.515

High

1413526

THUM2
U6 snRNA

1

2

High-throughput

0.515

High

1460261

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.515

High

122573

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.513

High

1332540

POC5
Centrosomal protein POC5

2

1

Small-scale

0.504

High

186139

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

951914

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

397277

ESR1
Estrogen receptor

1

7

High-throughput

0.500

High

1137600

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

389576

FINC
Fibronectin

1

1

High-throughput

0.489

High

1401009

PSKH2
Serine/threonine-protein kinase H2

1

1

High-throughput

0.489

High

1462695

CD11A
Cyclin-dependent kinase 11A

1

2

High-throughput

0.489

High

698393

MAP4
Microtubule-associated protein 4

1

1

High-throughput

0.481

High

1462414

WDR3
WD repeat-containing protein 3

1

12

High-throughput

0.481

High

125672

LEG9
Galectin-9

1

1

High-throughput

0.479

High

129576

MEN1
Menin

1

1

High-throughput

0.479

High

132394

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

134920

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.479

High

158014

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

170445

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

173591

XPO1
Exportin-1

1

5

High-throughput

0.479

High

191169

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

223438

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

248156

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

248371

HBP1
HMG box-containing protein 1

1

5

High-throughput

0.479

High

285534

EED
Polycomb protein EED

1

11

High-throughput

0.479

High

320168

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

331437

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.479

High

340066

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

3

Small-scale

0.479

High

349300

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.479

High

386383

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

4

Small-scale

0.479

High

401735

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

406821

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

420744

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.479

High

447603

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

473198

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

487903

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

590084

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

607246

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

630100

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

664837

CCND1
G1/S-specific cyclin-D1

1

1

High-throughput

0.479

High

696922

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

697302

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

731723

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

755037

H2B1B
Histone H2B type 1-B

1

5

High-throughput

0.479

High

769569

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

789601

PPARG
Peroxisome proliferator-activated receptor gamma

1

7

Small-scale

0.479

High

800181

COIL
Coilin

1

2

High-throughput

0.479

High

879643

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

883372

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

905317

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

964518

SUMO2
Small ubiquitin-related modifier 2

1

3

Small-scale

0.479

High

965351

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.479

High

971326

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

979362

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.479

High

982885

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.479

High

985081

RL31
Large ribosomal subunit protein eL31

1

4

High-throughput

0.479

High

998981

H31
Histone H3.1

1

10

High-throughput

0.479

High

1005267

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1017317

H33
Histone H3.3

1

10

High-throughput

0.479

High

1036010

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

1040949

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

1050579

UBE3A
Ubiquitin-protein ligase E3A

1

2

High-throughput

0.479

High

1067863

EP300
Histone acetyltransferase p300

1

8

High-throughput

0.479

High

1087626

GRSF1
G-rich sequence factor 1

1

6

High-throughput

0.479

High

1088629

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

9

High-throughput

0.479

High

1096282

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.479

High

1101112

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

1105117

TCOF
Treacle protein

1

4

Small-scale

0.479

High

1107358

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1115490

CUL4B
Cullin-4B

1

3

High-throughput

0.479

High

1127267

RBM39
RNA-binding protein 39

1

4

High-throughput

0.479

High

1134575

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

Small-scale

0.479

High

1135190

CUL7
Cullin-7

1

1

High-throughput

0.479

High

1138185

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

1138786

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1141080

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1145567

RBBP5
Retinoblastoma-binding protein 5

1

7

High-throughput

0.479

High

1149763

SSXT
Protein SSXT

1

1

High-throughput

0.479

High

1156909

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

1160624

SMN
Survival motor neuron protein

1

2

Small-scale

0.479

High

1197762

MIDN
Midnolin

1

1

High-throughput

0.479

High

1215910

RC3H1
Roquin-1

1

4

High-throughput

0.479

High

1238516

ZN746
Zinc finger protein 746

1

3

High-throughput

0.479

High

1290841

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.479

High

1313555

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1314493

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

1328571

NGEF
Ephexin-1

1

3

High-throughput

0.479

High

1329023

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

3

High-throughput

0.479

High

1339052

NUP43
Nucleoporin Nup43

1

11

High-throughput

0.479

High

1341173

WDR36
WD repeat-containing protein 36

1

12

High-throughput

0.479

High

1352850

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1358149

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

1361264

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

1364720

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1367647

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1380275

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

1384916

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

1385657

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1385928

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

1387654

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

1390320

TRI11
E3 ubiquitin-protein ligase TRIM11

1

5

Small-scale

0.479

High

1391876

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1401463

CIC
Protein capicua homolog

1

5

High-throughput

0.479

High

1404856

RING2
E3 ubiquitin-protein ligase RING2

1

5

High-throughput

0.479

High

1414626

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.479

High

1417534

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

1418650

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

8

High-throughput

0.479

High

1418846

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

1421023

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

1428679

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.479

High

1429027

WWTR1
WW domain-containing transcription regulator protein 1

1

5

High-throughput

0.479

High

1429405

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

1430652

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

1432732

TXNIP
Thioredoxin-interacting protein

1

5

Small-scale

0.479

High

1436575

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

1437245

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.479

High

1437890

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

1438097

RC3H2
Roquin-2

1

6

High-throughput

0.479

High

1438972

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

3

High-throughput

0.479

High

1446453

BRD7
Bromodomain-containing protein 7

1

7

High-throughput

0.479

High

1449259

RAD18
E3 ubiquitin-protein ligase RAD18

1

2

High-throughput

0.479

High

1450216

DCA13
DDB1- and CUL4-associated factor 13

1

9

Small-scale

0.479

High

1459388

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1461923

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

1490979

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

316464

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

Small-scale

0.458

High

332354

PDE8B
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

1

0

High-throughput

0.458

High

538152

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

766962

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

1033823

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1357616

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1372220

MED12
Mediator of RNA polymerase II transcription subunit 12

1

0

High-throughput

0.458

High

1397580

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1400527

CDK15
Cyclin-dependent kinase 15

1

0

High-throughput

0.458

High

1409566

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.458

High

1418539

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1450918

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.458

High

49043

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.445

High

430541

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

911703

NCBP2
Nuclear cap-binding protein subunit 2

1

6

High-throughput

0.445

High

994885

YBOX1
Y-box-binding protein 1

1

4

High-throughput

0.445

High

1032889

XPC
DNA repair protein complementing XP-C cells

1

3

High-throughput

0.445

High

1103464

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.445

High

1130540

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

High-throughput

0.445

High

1159349

TAF9
Transcription initiation factor TFIID subunit 9

1

1

Small-scale

0.445

High

1209815

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

1437422

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.445

High

1451435

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

2

High-throughput

0.445

High

294561

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

302999

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

8

High-throughput

0.437

High

353636

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

412854

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

419282

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.437

High

1136419

EMC2
ER membrane protein complex subunit 2

1

4

High-throughput

0.437

High

1141376

BRD3
Bromodomain-containing protein 3

1

11

High-throughput

0.437

High

1256189

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1277002

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1434287

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1461717

HECD1
E3 ubiquitin-protein ligase HECTD1

1

5

High-throughput

0.437

High

1490981

TRI17
E3 ubiquitin-protein ligase TRIM17

1

5

Small-scale

0.437

High

1490982

MAFB
Transcription factor MafB

1

4

High-throughput

0.437

High

1451146

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.426

High

1451900

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.426

High

1490593

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

887361

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

1337132

HIPK4
Homeodomain-interacting protein kinase 4

1

3

High-throughput

0.407

High

403044

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

1327875

NOPC1
NOP protein chaperone 1

2

0

High-throughput

0.324

High

155626

NEMP1
Nuclear envelope integral membrane protein 1

1

0

High-throughput

0.279

Low

914380

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

516789

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.249

Low

1025969

NDP
Norrin

1

0

Small-scale

0.249

Low

1309533

DAA19
Dynein axonemal assembly factor 19

1

0

High-throughput

0.249

Low

1322474

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

1197909

S39AC
Zinc transporter ZIP12

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025