HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 728 Hs			1 768
+	Hs
		411713 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		655358 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042817 VAV3_HUMAN (622-719): 2.22e-15: 82.2: 35.35		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		924552 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		855795 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		789064 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		337467 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		337468 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Dm
		186280 O18683_DROME (319-488): 8.23e-19: 92.2: 21.64		CUL1_DROME (29-768): 0: 669: 27.49
+	Dm
		113895 M9PAY7_DROME (320-471): 8.07e-14: 72.5: 24.84		CUL1_DROME (29-768): 0: 669: 27.49