HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 822
+	Hs
		129299 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		129201 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		129160 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		129170 P85B_HUMAN (1-728): 0: 549: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		129278 P85B_HUMAN (1-728): 0: 549: 100.00		ROR1_HUMAN (363-809): 2.11e-111: 364: 31.80
+	Hs
		608065 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		385265 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		129284 P85B_HUMAN (1-728): 0: 549: 100.00		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (513-814): 4.91e-68: 247: 42.43
+	Hs
		129350 P85B_HUMAN (1-728): 0: 549: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Hs
		129213 P85B_HUMAN (1-728): 0: 549: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Hs
		665299 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		666628 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07