HitPredict

Interactor 1: HES6 (Q96HZ4)
Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6)
Gene: HES6

Interactor 2: NGN3 (Q9Y4Z2)
Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5)
Gene: NEUROG3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus
and 2 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 224
Hs

1 214
+ Dr
+ Dm
+ Dm
+ Mm
+ Dm
+ Mm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Hs
+ Mm
+ Hs
+ Dm
+ Dm
+ Dm
+ Dr

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Last updated: 15 Jul 2024