Protein: THEM6
Protein THEM6 (Mesenchymal stem cell protein DSCD75) (Thioesterase superfamily member 6)

Gene: THEM6
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q8WUY1

Gene Ontology (top 5):
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

396592

ESR1
Estrogen receptor

3

2

High-throughput

0.593

High

962318

RHOA
Transforming protein RhoA

3

7

High-throughput

0.578

High

1349299

TBC15
TBC1 domain family member 15

2

0

High-throughput

0.576

High

1357306

TSN17
Tetraspanin-17

2

1

High-throughput

0.558

High

410963

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

High-throughput

0.533

High

914310

EFNA4
Ephrin-A4

1

0

High-throughput

0.513

High

182690

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

349505

TSN15
Tetraspanin-15

1

1

High-throughput

0.489

High

351933

S1PR4
Sphingosine 1-phosphate receptor 4

1

3

High-throughput

0.489

High

575683

GPIX
Platelet glycoprotein IX

1

1

High-throughput

0.489

High

638220

S1PR1
Sphingosine 1-phosphate receptor 1

1

2

High-throughput

0.489

High

1085353

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

2

High-throughput

0.489

High

1142116

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

1357333

LPAR2
Lysophosphatidic acid receptor 2

1

3

High-throughput

0.489

High

777728

VGFR3
Vascular endothelial growth factor receptor 3

1

0

High-throughput

0.479

High

178346

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

980045

H4
Histone H4

1

0

High-throughput

0.458

High

126718

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.437

High

343269

ERR2
Steroid hormone receptor ERR2

1

2

High-throughput

0.437

High

363623

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.437

High

466384

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.437

High

581196

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.437

High

910146

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.437

High

953587

RAC3
Ras-related C3 botulinum toxin substrate 3

1

6

High-throughput

0.437

High

955417

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.437

High

978197

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.437

High

988563

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.437

High

1151797

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.437

High

1294221

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.437

High

1334485

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.437

High

1357305

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

1357309

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.437

High

1357325

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

1357328

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.437

High

1357332

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.437

High

1357344

S12A6
Solute carrier family 12 member 6

1

2

Small-scale

0.437

High

1357345

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

High-throughput

0.437

High

211158

CTR4
Cationic amino acid transporter 4

1

1

High-throughput

0.407

High

663633

SC6A2
Sodium-dependent noradrenaline transporter

1

4

High-throughput

0.407

High

828578

S26A3
Chloride anion exchanger

1

1

High-throughput

0.407

High

869631

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

4

High-throughput

0.407

High

870275

S6A12
Sodium- and chloride-dependent betaine transporter

1

4

High-throughput

0.407

High

1031825

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.407

High

1199083

CTL4
Choline transporter-like protein 4

1

4

High-throughput

0.407

High

1207882

S27A3
Long-chain fatty acid transport protein 3

1

1

High-throughput

0.407

High

1230829

SL9A4
Sodium/hydrogen exchanger 4

1

1

High-throughput

0.407

High

1308915

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

1309756

CTL2
Choline transporter-like protein 2

1

4

High-throughput

0.407

High

1326593

CTL3
Choline transporter-like protein 3

1

4

High-throughput

0.407

High

1326968

SVOP
Synaptic vesicle 2-related protein

1

1

High-throughput

0.407

High

1334097

S4A11
Solute carrier family 4 member 11

1

2

High-throughput

0.407

High

1336021

CTL5
Choline transporter-like protein 5

1

4

High-throughput

0.407

High

1357304

CTL1
Choline transporter-like protein 1

1

4

High-throughput

0.407

High

1357311

S6A18
Inactive sodium-dependent neutral amino acid transporter B(0)AT3

1

4

High-throughput

0.407

High

1357312

B3A4
Anion exchange protein 4

1

2

High-throughput

0.407

High

1357314

S26A8
Testis anion transporter 1

1

1

High-throughput

0.407

High

1357315

SL9A7
Sodium/hydrogen exchanger 7

1

1

High-throughput

0.407

High

1357343

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

2

High-throughput

0.407

High

1357346

S12A4
Solute carrier family 12 member 4

1

3

High-throughput

0.407

High

1357347

S27A5
Long-chain fatty acid transport protein 5

1

1

High-throughput

0.407

High

1357351

S4A7
Sodium bicarbonate cotransporter 3

1

2

High-throughput

0.407

High

1357350

SRPRB
Signal recognition particle receptor subunit beta

4

0

High-throughput

0.360

High

1355912

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

2

0

High-throughput

0.328

High

191970

TEX28
Testis-specific protein TEX28

2

0

High-throughput

0.313

High

564123

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.313

High

1357324

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.313

High

166175

AIM2
Interferon-inducible protein AIM2

1

0

High-throughput

0.279

Low

219339

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

320480

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.279

Low

700799

DMB
HLA class II histocompatibility antigen, DM beta chain

1

0

High-throughput

0.279

Low

771191

APJ
Apelin receptor

1

0

High-throughput

0.279

Low

835340

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.279

Low

922832

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

0

High-throughput

0.279

Low

939950

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.279

Low

946575

EVA1C
Protein eva-1 homolog C

1

0

High-throughput

0.279

Low

1126329

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

1159215

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1161851

AMHR2
Anti-Muellerian hormone type-2 receptor

1

0

High-throughput

0.279

Low

1180939

HFE
Hereditary hemochromatosis protein

1

0

High-throughput

0.279

Low

1203746

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1204517

XKR6
XK-related protein 6

1

0

High-throughput

0.279

Low

1248414

CP054
Transmembrane protein C16orf54

1

0

High-throughput

0.279

Low

1248536

LCTL
Lactase-like protein

1

0

High-throughput

0.279

Low

1258842

CYS1
Cystin-1

1

0

High-throughput

0.279

Low

1277731

TMC6
Transmembrane channel-like protein 6

1

0

High-throughput

0.279

Low

1291431

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.279

Low

1310264

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1322560

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.279

Low

1326657

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.279

Low

1333579

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1357307

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.279

Low

1357318

P2RX4
P2X purinoceptor 4

1

0

High-throughput

0.279

Low

1357321

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.279

Low

1357323

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.279

Low

1357326

CHST8
Carbohydrate sulfotransferase 8

1

0

High-throughput

0.279

Low

1357327

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1357330

TM231
Transmembrane protein 231

1

0

High-throughput

0.279

Low

1357339

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.279

Low

1157009

NTRK3
NT-3 growth factor receptor

1

0

High-throughput

0.261

Low

124629

EYA2
Protein phosphatase EYA2

1

0

High-throughput

0.249

Low

129280

MEN1
Menin

1

0

High-throughput

0.249

Low

218537

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

294084

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

386019

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.249

Low

582598

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.249

Low

589254

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

611253

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.249

Low

696037

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768738

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

831128

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

904966

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

927448

ATX1
Ataxin-1

1

0

High-throughput

0.249

Low

947237

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

1004887

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1113832

CUL3
Cullin-3

1

0

High-throughput

0.249

Low

1162442

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1178279

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1238753

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

1249055

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1254808

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1286845

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.249

Low

1288484

LBN
Limbin

1

0

High-throughput

0.249

Low

1290913

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.249

Low

1293093

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1309857

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.249

Low

1351217

MCLN3
Mucolipin-3

1

0

High-throughput

0.249

Low

1352653

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1357308

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1357310

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

1357313

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low

1357316

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1357317

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

1357320

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.249

Low

1357322

MTMRC
Myotubularin-related protein 12

1

0

High-throughput

0.249

Low

1357329

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1357331

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1357334

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1357335

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1357336

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1357337

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

1357338

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.249

Low

1357340

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1357341

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1357342

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.249

Low

851187

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.232

Low

1060378

SLC31
Amino acid transporter heavy chain SLC3A1

1

0

High-throughput

0.232

Low

1093554

TRDN
Triadin

1

0

High-throughput

0.232

Low

1211936

S35F1
Solute carrier family 35 member F1

1

0

High-throughput

0.232

Low

1213661

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.232

Low

1236246

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1290563

S47A2
Multidrug and toxin extrusion protein 2

1

0

High-throughput

0.232

Low

1316335

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.232

Low

1357319

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

0

High-throughput

0.232

Low

1357348

TMED5
Transmembrane emp24 domain-containing protein 5

1

0

High-throughput

0.232

Low

1357349

PCDGE
Protocadherin gamma-B2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025