HitPredict

Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: NFIP2 (Q9NV92)
NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413)
Gene: NDFIP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 20522958
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 903 Hs			1 336
+	Hs
		1327920 WWP1_HUMAN (1-903): 0: 832: 57.54		NFIP2_HUMAN (1-336): 0: 619: 100.00
+	Hs
		125746 WWP2_HUMAN (1-903): 0: 816: 54.08		NFIP2_HUMAN (1-336): 0: 619: 100.00
+	Hs
		1299647 NED4L_HUMAN (5-900): 0: 762: 32.14		NFIP2_HUMAN (1-336): 0: 619: 100.00
+	Hs
		808291 NEDD4_HUMAN (90-900): 0: 673: 34.16		NFIP2_HUMAN (1-336): 0: 619: 100.00
+	Hs
		1294848 ITCH_HUMAN (1-903): 0: 926: 100.00		NFIP1_HUMAN (99-335): 1.27e-113: 330: 55.46
+	Mm
		1208047 ITCH_MOUSE (1-903): 0: 885: 91.16		NFIP1_MOUSE (99-335): 2.33e-112: 327: 53.36
+	Hs
		1311857 WWP1_HUMAN (1-903): 0: 832: 57.54		NFIP1_HUMAN (99-335): 1.27e-113: 330: 55.46
+	Hs
		125686 WWP2_HUMAN (1-903): 0: 816: 54.08		NFIP1_HUMAN (99-335): 1.27e-113: 330: 55.46
+	Hs
		1299617 NED4L_HUMAN (5-900): 0: 762: 32.14		NFIP1_HUMAN (99-335): 1.27e-113: 330: 55.46
+	Hs
		808249 NEDD4_HUMAN (90-900): 0: 673: 34.16		NFIP1_HUMAN (99-335): 1.27e-113: 330: 55.46
+	Dm
		1374794 SUDX_DROME (19-903): 0: 788: 48.29		Q9VVJ5_DROME (109-335): 5.57e-67: 213: 26.02
+	Mm
		93279 E9PXB7_MOUSE (86-900): 0: 654: 34.22		NFIP1_MOUSE (99-335): 2.33e-112: 327: 53.36
+	Dm
		1374786 NEDD4_DROME (3-901): 0: 720: 29.95		Q9VVJ5_DROME (109-335): 5.57e-67: 213: 26.02
+	Rn
		1137274 NEDD4_RAT (7-426): 3.03e-54: 205: 18.07		NFIP1_RAT (99-335): 5.25e-111: 323: 53.36
+	Mm
		808368 NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38		NFIP1_MOUSE (99-335): 2.33e-112: 327: 53.36
+	Hs
		1311860 SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71		NFIP1_HUMAN (99-335): 1.27e-113: 330: 55.46
+	Dm
		1360300 SMUF1_DROME (16-518): 1.15e-39: 161: 16.19		Q9VVJ5_DROME (109-335): 5.57e-67: 213: 26.02