Protein: VPP1
V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)

Gene: VPP1, ATP6V0A1
Organism: Homo sapiens
Interactions: 222
UniProt ID: Q93050

Gene Ontology (top 5):
GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005765 - lysosomal membrane
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

961557

VA0D1
V-type proton ATPase subunit d 1

5

14

High-throughput

0.919

High

692244

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

3

9

High-throughput

0.855

High

1371997

VPP2
V-type proton ATPase 116 kDa subunit a 2

3

7

High-throughput

0.855

High

637112

VATC1
V-type proton ATPase subunit C 1

3

12

High-throughput

0.839

High

1331440

VA0D2
V-type proton ATPase subunit d 2

3

14

High-throughput

0.839

High

186479

VA0E1
V-type proton ATPase subunit e 1

2

4

High-throughput

0.811

High

1371986

VATH
V-type proton ATPase subunit H

2

3

High-throughput

0.789

High

276851

VATG1
V-type proton ATPase subunit G 1

2

8

High-throughput

0.776

High

784800

VATE1
V-type proton ATPase subunit E 1

2

8

High-throughput

0.776

High

292709

RENR
Renin receptor

6

5

High-throughput

0.736

High

583100

VATB1
V-type proton ATPase subunit B, kidney isoform

5

9

High-throughput

0.706

High

1106804

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

7

High-throughput

0.691

High

1371953

MYADM
Myeloid-associated differentiation marker

1

1

High-throughput

0.691

High

1155251

VAS1
V-type proton ATPase subunit S1

4

6

High-throughput

0.691

High

637054

VATB2
V-type proton ATPase subunit B, brain isoform

4

9

Small-scale

0.683

High

590327

MUC1
Mucin-1

3

2

High-throughput

0.667

High

1338670

T185A
Transmembrane protein 185A

3

1

High-throughput

0.667

High

1371954

SERC2
Serine incorporator 2

3

1

High-throughput

0.667

High

337127

NPT2B
Sodium-dependent phosphate transport protein 2B

3

1

High-throughput

0.662

High

1164260

VATF
V-type proton ATPase subunit F

3

6

High-throughput

0.662

High

1327033

VMA12
Vacuolar ATPase assembly protein VMA12

3

6

High-throughput

0.662

High

1371998

VATD
V-type proton ATPase subunit D

3

5

High-throughput

0.662

High

800549

VATA
V-type proton ATPase catalytic subunit A

3

13

Small-scale

0.650

High

320483

TM63A
Mechanosensitive cation channel TMEM63A

2

3

High-throughput

0.628

High

378872

CD4
T-cell surface glycoprotein CD4

2

1

High-throughput

0.628

High

898388

BCAM
Basal cell adhesion molecule

2

5

High-throughput

0.628

High

1243295

MEAK7
MTOR-associated protein MEAK7

2

1

High-throughput

0.628

High

1315466

K2013
Uncharacterized protein KIAA2013

2

6

High-throughput

0.628

High

341217

VATG2
V-type proton ATPase subunit G 2

1

8

High-throughput

0.618

High

127384

LEG8
Galectin-8

2

8

High-throughput

0.611

High

380466

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

2

1

High-throughput

0.611

High

478712

HXB5
Homeobox protein Hox-B5

2

1

High-throughput

0.611

High

845745

MUC18
Cell surface glycoprotein MUC18

2

5

High-throughput

0.611

High

900969

RAB5C
Ras-related protein Rab-5C

2

4

High-throughput

0.611

High

901455

RAB7A
Ras-related protein Rab-7a

2

4

High-throughput

0.611

High

1154700

VAMP3
Vesicle-associated membrane protein 3

2

5

High-throughput

0.611

High

1371972

ARL8B
ADP-ribosylation factor-like protein 8B

2

6

High-throughput

0.611

High

538652

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

2

3

High-throughput

0.601

High

1102803

UT1
Urea transporter 1

2

1

High-throughput

0.601

High

1371950

VMA22
Vacuolar ATPase assembly protein VMA22

2

3

High-throughput

0.601

High

329852

SNX4
Sorting nexin-4

2

0

High-throughput

0.588

High

1371944

VATE2
V-type proton ATPase subunit E 2

1

8

High-throughput

0.575

High

1205915

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

2

High-throughput

0.574

High

1143081

KPCD1
Serine/threonine-protein kinase D1

2

2

High-throughput

0.571

High

770809

HRH1
Histamine H1 receptor

1

2

High-throughput

0.541

High

1371946

SEH1
Nucleoporin SEH1

1

1

High-throughput

0.541

High

64956

ARRD5
Arrestin domain-containing protein 5

1

1

High-throughput

0.536

High

219207

LTOR5
Ragulator complex protein LAMTOR5

1

1

High-throughput

0.536

High

219449

S26A4
Pendrin

1

3

High-throughput

0.536

High

391646

FRIH
Ferritin heavy chain

1

1

High-throughput

0.536

High

480875

LEG1
Galectin-1

1

8

High-throughput

0.536

High

609770

LEG3
Galectin-3

1

8

High-throughput

0.536

High

710411

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.536

High

878337

MRP
MARCKS-related protein

1

1

High-throughput

0.536

High

908040

VAMP7
Vesicle-associated membrane protein 7

1

1

High-throughput

0.536

High

932746

EMP3
Epithelial membrane protein 3

1

1

High-throughput

0.536

High

934312

AQP5
Aquaporin-5

1

4

High-throughput

0.536

High

1106289

ROCK1
Rho-associated protein kinase 1

1

1

High-throughput

0.536

High

1115880

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.536

High

1219813

PLPP4
Phospholipid phosphatase 4

1

1

High-throughput

0.536

High

1233399

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.536

High

1252072

RN19B
E3 ubiquitin-protein ligase RNF19B

1

2

High-throughput

0.536

High

1293556

F131B
Protein FAM131B

1

1

High-throughput

0.536

High

1312964

S35F2
Solute carrier family 35 member F2

1

2

High-throughput

0.536

High

1315321

ZDH23
Palmitoyltransferase ZDHHC23

1

2

High-throughput

0.536

High

1357628

SFT2A
Vesicle transport protein SFT2A

1

1

High-throughput

0.536

High

1371962

SLK
STE20-like serine/threonine-protein kinase

1

1

High-throughput

0.536

High

1371971

ANLN
Anillin

1

1

High-throughput

0.536

High

1371975

M4A12
Membrane-spanning 4-domains subfamily A member 12

1

1

High-throughput

0.536

High

1371978

GPC5D
G-protein coupled receptor family C group 5 member D

1

1

High-throughput

0.536

High

1371987

TBD
Tubulin delta chain

1

1

High-throughput

0.536

High

1371988

FZD10
Frizzled-10

1

1

High-throughput

0.536

High

1371995

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.536

High

1371999

KC1G3
Casein kinase I isoform gamma-3

1

2

High-throughput

0.536

High

131191

CLIC1
Chloride intracellular channel protein 1

1

0

High-throughput

0.518

High

923619

TTC3
E3 ubiquitin-protein ligase TTC3

1

0

High-throughput

0.518

High

166972

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.513

High

178566

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

0

High-throughput

0.513

High

557419

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

611272

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.513

High

684504

CTNA2
Catenin alpha-2

1

0

High-throughput

0.513

High

708995

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

845529

PI2R
Prostacyclin receptor

1

0

High-throughput

0.513

High

855367

5HT3A
5-hydroxytryptamine receptor 3A

1

0

High-throughput

0.513

High

1026164

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

1208129

S35D3
Solute carrier family 35 member D3

1

0

High-throughput

0.513

High

1316338

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.513

High

1367771

TFG
Protein TFG

1

0

High-throughput

0.513

High

1369928

ARHG1
Rho guanine nucleotide exchange factor 1

1

0

High-throughput

0.513

High

1371963

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1371965

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.513

High

1371977

NSMA2
Sphingomyelin phosphodiesterase 3

1

0

High-throughput

0.513

High

1371993

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.513

High

1371994

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.513

High

1371955

CYH2
Cytohesin-2

1

4

Small-scale

0.501

High

1191788

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

3

High-throughput

0.489

High

1328108

TTC9C
Tetratricopeptide repeat protein 9C

1

3

High-throughput

0.489

High

1371948

BT3L4
Transcription factor BTF3 homolog 4

1

1

High-throughput

0.489

High

125560

LEG9
Galectin-9

1

8

High-throughput

0.479

High

165634

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.479

High

178353

NPC1
NPC intracellular cholesterol transporter 1

1

4

High-throughput

0.479

High

178821

SCAM1
Secretory carrier-associated membrane protein 1

1

1

High-throughput

0.479

High

189759

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

218582

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

242501

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

303174

RGS20
Regulator of G-protein signaling 20

1

1

High-throughput

0.479

High

412392

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

466395

RHOC
Rho-related GTP-binding protein RhoC

1

4

High-throughput

0.479

High

508380

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

581214

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

601399

RHOQ
Rho-related GTP-binding protein RhoQ

1

6

High-throughput

0.479

High

618474

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

1

High-throughput

0.479

High

630921

RAB4A
Ras-related protein Rab-4A

1

5

High-throughput

0.479

High

907825

CLCN7
H(+)/Cl(-) exchange transporter 7

1

1

High-throughput

0.479

High

910157

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.479

High

955448

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

957989

RAB14
Ras-related protein Rab-14

1

5

High-throughput

0.479

High

962351

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

981336

RAB1A
Ras-related protein Rab-1A

1

4

High-throughput

0.479

High

1133951

RB39A
Ras-related protein Rab-39A

1

5

High-throughput

0.479

High

1144293

STK38
Serine/threonine-protein kinase 38

1

2

High-throughput

0.479

High

1151812

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.479

High

1231452

ATLA3
Atlastin-3

1

1

High-throughput

0.479

High

1251098

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

1

High-throughput

0.479

High

1326857

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.479

High

1330341

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.479

High

1352297

RN128
E3 ubiquitin-protein ligase RNF128

1

4

High-throughput

0.479

High

1366954

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1371949

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

1371960

RB33B
Ras-related protein Rab-33B

1

3

High-throughput

0.479

High

1371964

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1371966

RHOJ
Rho-related GTP-binding protein RhoJ

1

6

High-throughput

0.479

High

1371967

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1371968

RHOF
Rho-related GTP-binding protein RhoF

1

6

High-throughput

0.479

High

1371974

MIOS
GATOR2 complex protein MIOS

1

2

High-throughput

0.479

High

1371983

DNJ5B
DnaJ homolog subfamily C member 5B

1

2

High-throughput

0.479

High

1371985

S12A6
Solute carrier family 12 member 6

1

5

Small-scale

0.479

High

1371991

TBD2B
TBC1 domain family member 2B

1

1

High-throughput

0.479

High

272722

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

0

High-throughput

0.458

High

346157

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

414351

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

446003

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

451042

LDHB
L-lactate dehydrogenase B chain

1

0

Small-scale

0.458

High

945155

CORO7
Coronin-7

1

0

High-throughput

0.458

High

1140654

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1197660

MIDN
Midnolin

1

0

High-throughput

0.458

High

1228839

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

0

High-throughput

0.458

High

1246909

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1249080

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1277147

VP35L
VPS35 endosomal protein-sorting factor-like

1

0

High-throughput

0.458

High

1338563

SYNE1
Nesprin-1

1

0

High-throughput

0.458

High

1360794

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

1371957

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

1371969

CPAP
Centrosomal P4.1-associated protein

1

0

High-throughput

0.458

High

1371979

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1371984

NUFP1
FMR1-interacting protein NUFIP1

1

0

High-throughput

0.458

High

1371996

STA13
StAR-related lipid transfer protein 13

1

0

High-throughput

0.458

High

1372000

S4A7
Sodium bicarbonate cotransporter 3

1

0

High-throughput

0.458

High

65415

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

3

High-throughput

0.445

High

211161

CTR4
Cationic amino acid transporter 4

1

5

High-throughput

0.445

High

279578

LAT3
Large neutral amino acids transporter small subunit 3

1

4

High-throughput

0.445

High

530180

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

574110

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

3

High-throughput

0.445

High

720397

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

4

High-throughput

0.445

High

828579

S26A3
Chloride anion exchanger

1

3

High-throughput

0.445

High

835000

S19A1
Reduced folate transporter

1

2

High-throughput

0.445

High

880852

NRAM2
Natural resistance-associated macrophage protein 2

1

1

High-throughput

0.445

High

912703

CTR2
Cationic amino acid transporter 2

1

5

High-throughput

0.445

High

933456

S12A2
Solute carrier family 12 member 2

1

4

High-throughput

0.445

High

934961

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

1134139

NTCP
Hepatic sodium/bile acid cotransporter

1

1

High-throughput

0.445

High

1168615

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

1

High-throughput

0.445

High

1234894

PKHA7
Pleckstrin homology domain-containing family A member 7

1

7

High-throughput

0.445

High

1238887

MFS12
Major facilitator superfamily domain-containing protein 12

1

3

High-throughput

0.445

High

1251165

ZNT10
Calcium/manganese antiporter SLC30A10

1

4

High-throughput

0.445

High

1288902

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

1

High-throughput

0.445

High

1324746

S35F6
Solute carrier family 35 member F6

1

3

High-throughput

0.445

High

1324783

LAT4
Large neutral amino acids transporter small subunit 4

1

4

High-throughput

0.445

High

1336911

VGLU3
Vesicular glutamate transporter 3

1

3

High-throughput

0.445

High

1340547

MFSD8
Major facilitator superfamily domain-containing protein 8

1

2

High-throughput

0.445

High

1353704

MOT10
Monocarboxylate transporter 10

1

7

High-throughput

0.445

High

1371956

SC6A7
Sodium-dependent proline transporter

1

4

High-throughput

0.445

High

1371958

S46A2
Solute carrier family 46 member 2

1

3

High-throughput

0.445

High

1371959

S19A3
Thiamine transporter 2

1

2

High-throughput

0.445

High

1371970

SO1B3
Solute carrier organic anion transporter family member 1B3

1

1

High-throughput

0.445

High

1371980

VGLU2
Vesicular glutamate transporter 2

1

3

High-throughput

0.445

High

1371981

RHCG
Ammonium transporter Rh type C

1

2

High-throughput

0.445

High

1371982

S53A1
Solute carrier family 53 member 1

1

6

High-throughput

0.445

High

1371989

S6A14
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

1

4

High-throughput

0.445

High

1371990

FLVC2
Choline/ethanolamine transporter FLVCR2

1

5

High-throughput

0.445

High

1371992

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

1238763

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1254930

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1371961

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

255154

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

1113915

CUL3
Cullin-3

1

0

High-throughput

0.426

High

1119240

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1308533

SL9A9
Sodium/hydrogen exchanger 9

1

0

High-throughput

0.426

High

1325884

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.426

High

1334277

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.426

High

1371951

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

75574

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

1333416

S43A3
Equilibrative nucleobase transporter 1

1

4

High-throughput

0.407

High

1128603

ZN267
Zinc finger protein 267

1

0

High-throughput

0.282

High

1371952

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.279

Low

1371973

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.279

Low

1233166

ABLM2
Actin-binding LIM protein 2

1

0

High-throughput

0.251

Low

106406

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

589336

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696132

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768820

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1117794

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.249

Low

1136303

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

1155630

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1186223

CEA21
Cell adhesion molecule CEACAM21

1

0

High-throughput

0.249

Low

1204886

MKS3
Meckelin

1

0

High-throughput

0.249

Low

1340602

CFA61
Cilia- and flagella-associated protein 61

1

0

High-throughput

0.249

Low

1371945

BORC7
BLOC-1-related complex subunit 7

1

0

High-throughput

0.249

Low

1371947

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

1371976

ING3
Inhibitor of growth protein 3

1

0

High-throughput

0.249

Low

1372001

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.249

Low

1180300

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025