HitPredict

Interactor 1: ASPP1 (Q96KQ4)
Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)
Gene: PPP1R13B

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	21041411, 21041410, 24255178
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1090 Hs			1 1088
+	Hs
		1043761 ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1127324 TGO1_HUMAN (10-584): 5.07e-78: 283: 16.35		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		325856 ASPP1_HUMAN (1-1090): 1.25e-150: 479: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325722 ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325765 TGO1_HUMAN (10-584): 5.07e-78: 283: 16.35		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		166871 ANR28_HUMAN (709-1086): 2.22e-47: 186: 12.88		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325811 ANR52_HUMAN (751-1080): 6.18e-45: 178: 14.04		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		161275 MYPT1_HUMAN (821-1021): 1.28e-14: 81.1: 24.27		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		1069637 EHMT2_HUMAN (643-994): 1.76e-30: 132: 12.47		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Hs
		1137887 DOT1L_HUMAN (94-844): 1.19e-72: 266: 16.97		MRCKA_HUMAN (656-1007): 6.11e-76: 277: 41.23
+	Hs
		1035191 ANR49_HUMAN (852-992): 1.66e-22: 99.5: 28.28		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		254502 ANR49_HUMAN (852-992): 1.66e-22: 99.5: 28.28		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90
+	Hs
		161361 MYPT1_HUMAN (821-1021): 1.28e-14: 81.1: 24.27		DMPK_HUMAN (627-1007): 4.98e-66: 236: 35.90