HitPredict

Interactor 1: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 236 Hs			1 761
+	Hs
		1183621 RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		951478 RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		925751 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		1050126 RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Gg
		1154344 Q6LC82_CHICK (32-217): 3.34e-76: 230: 53.23		Q9DG15_CHICK (1-761): 2.03e-155: 471: 85.41
+	Hs
		950990 RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		1050143 RHOV_HUMAN (1-236): 3.37e-76: 231: 100.00		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		925274 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Dm
		185486 O18332_DROME (21-234): 4.65e-75: 227: 21.01		GIT_DROME (9-633): 5.05e-78: 267: 35.78
+	Hs
		925724 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		925736 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Hs
		925423 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		HACE1_HUMAN (134-500): 3.45e-54: 203: 15.80
+	Hs
		925551 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		AGAP2_HUMAN (2-223): 3.67e-52: 198: 32.00
+	Hs
		1021421 RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		925478 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		ARAP2_HUMAN (7-223): 6.18e-51: 195: 27.15
+	Hs
		925529 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		ARAP1_HUMAN (8-205): 6.26e-49: 188: 29.35
+	Hs
		950953 RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		925238 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Mm
		71299 RAB13_MOUSE (25-236): 2.24e-78: 235: 24.19		ANR44_MOUSE (170-529): 3.82e-36: 148: 12.36
+	Hs
		925204 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		ANK2_HUMAN (162-494): 7.25e-30: 129: 9.52