HitPredict

Interactor 1: NSE2 (Q96MF7)
E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog)
Gene: NSMCE2

Interactor 2: SMC6 (Q96SB8)
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Gene: SMC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

The method score is based on:

Property	Details
Experiments	26496610, 33961781, 18086888
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000722 - telomere maintenance via recombination GO:0000724 - double-strand break repair via homologous recombination GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm and 6 others more... GO:0016605 - PML body GO:0016925 - protein sumoylation GO:0030915 - Smc5-Smc6 complex GO:0032204 - regulation of telomere maintenance GO:0090398 - cellular senescence GO:0140588 - chromatin looping
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	247
Hs

1	1091

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024