Protein: ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)

Gene: ODPB, PDHB
Organism: Homo sapiens
Interactions: 221
UniProt ID: P11177

Gene Ontology (top 5):
GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

470823

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

8

16

Small-scale

0.970

High

522365

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

5

8

Small-scale

0.929

High

132815

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

4

8

Small-scale

0.892

High

484345

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

4

4

High-throughput

0.699

High

539179

PDK1
[Pyruvate dehydrogenase

4

6

High-throughput

0.686

High

539132

STA5A
Signal transducer and activator of transcription 5A

3

1

High-throughput

0.675

High

539107

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

3

5

High-throughput

0.667

High

539140

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

3

5

High-throughput

0.667

High

539155

CANB1
Calcineurin subunit B type 1

3

1

High-throughput

0.667

High

539160

PP2BA
Protein phosphatase 3 catalytic subunit alpha

3

5

High-throughput

0.667

High

539180

PDK2
[Pyruvate dehydrogenase

3

6

High-throughput

0.667

High

539181

PDK3
[Pyruvate dehydrogenase

3

6

High-throughput

0.667

High

539172

FHL2
Four and a half LIM domains protein 2

3

0

High-throughput

0.638

High

539211

BANP
Protein BANP

3

0

High-throughput

0.638

High

528946

TAU
Microtubule-associated protein tau

2

6

High-throughput

0.628

High

539164

FOXD4
Forkhead box protein D4

2

1

High-throughput

0.628

High

539121

AKT1
RAC-alpha serine/threonine-protein kinase

2

3

High-throughput

0.614

High

539169

CUL3
Cullin-3

2

2

High-throughput

0.611

High

539193

DUS29
Dual specificity phosphatase 29

2

0

High-throughput

0.595

High

371020

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

539138

YAP1
Transcriptional coactivator YAP1

2

9

Small-scale

0.584

High

539143

PPT1
Palmitoyl-protein thioesterase 1

2

1

Small-scale

0.584

High

539277

HECD1
E3 ubiquitin-protein ligase HECTD1

2

4

High-throughput

0.584

High

539221

TRI63
E3 ubiquitin-protein ligase TRIM63

2

5

Small-scale

0.584

High

539243

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

3

High-throughput

0.578

High

539119

ODPAT
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

1

16

Small-scale

0.575

High

400193

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

2

High-throughput

0.571

High

539113

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

539259

ECT2
Protein ECT2

2

0

High-throughput

0.559

High

135461

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.536

High

539106

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

539114

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

3

High-throughput

0.536

High

539120

CLIP1
CAP-Gly domain-containing linker protein 1

1

2

High-throughput

0.536

High

539127

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

7

High-throughput

0.536

High

539145

STA5B
Signal transducer and activator of transcription 5B

1

1

High-throughput

0.536

High

539201

COX15
Heme A synthase COX15

1

1

High-throughput

0.536

High

539204

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

539229

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.536

High

539234

PARK7
Parkinson disease protein 7

1

2

High-throughput

0.536

High

539273

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.536

High

539147

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.518

High

539131

CCNF
Cyclin-F

1

1

High-throughput

0.515

High

369009

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

539200

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.513

High

539283

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.513

High

539109

RCC1
Regulator of chromosome condensation

1

1

High-throughput

0.508

High

539112

ANXA7
Annexin A7

1

3

High-throughput

0.508

High

539183

T22D1
TSC22 domain family protein 1

1

2

High-throughput

0.508

High

539104

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

2

High-throughput

0.494

High

539117

AA2AR
Adenosine receptor A2a

1

1

High-throughput

0.494

High

539154

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.494

High

388957

FINC
Fibronectin

1

2

High-throughput

0.489

High

539125

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.489

High

539129

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

539235

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

Small-scale

0.481

High

183581

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

222667

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

281864

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

287228

RF1M
Peptide chain release factor 1, mitochondrial

1

3

High-throughput

0.479

High

315053

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

325657

UBR5
E3 ubiquitin-protein ligase UBR5

1

4

Small-scale

0.479

High

349759

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

361597

OTC
Ornithine transcarbamylase, mitochondrial

1

2

High-throughput

0.479

High

377165

SOMA
Somatotropin

1

1

High-throughput

0.479

High

403781

GCR
Glucocorticoid receptor

1

2

Small-scale

0.479

High

411255

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

536375

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

539108

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

539110

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

539116

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

539118

PML
Protein PML

1

6

High-throughput

0.479

High

539122

AKT2
RAC-beta serine/threonine-protein kinase

1

4

High-throughput

0.479

High

539123

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

539126

BASI
Basigin

1

3

High-throughput

0.479

High

539130

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

539135

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.479

High

539136

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

539141

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

539142

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

539144

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

539148

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

539150

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

539151

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

539152

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

539153

RHOB
Rho-related GTP-binding protein RhoB

1

2

High-throughput

0.479

High

539158

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

539162

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

539163

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

539165

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

539166

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.479

High

539167

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.479

High

539168

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

539170

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

539171

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

539175

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

539176

MDC1
Mediator of DNA damage checkpoint protein 1

1

3

High-throughput

0.479

High

539184

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

539186

RBBP7
Histone-binding protein RBBP7

1

4

High-throughput

0.479

High

539195

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

539199

MOB2
MOB kinase activator 2

1

1

High-throughput

0.479

High

539202

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.479

High

539203

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

539205

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.479

High

539207

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

539213

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

539216

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

539217

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

3

Small-scale

0.479

High

539219

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

539220

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.479

High

539222

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

539225

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

539231

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.479

High

539233

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.479

High

539236

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

539241

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

539242

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

539246

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

539249

MTRFR
Mitochondrial translation release factor in rescue

1

3

High-throughput

0.479

High

539250

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

539252

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

539256

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

539258

AKTIP
AKT-interacting protein

1

3

Small-scale

0.479

High

539260

BRF2
Transcription factor IIIB 50 kDa subunit

1

2

High-throughput

0.479

High

539261

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

539262

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

539264

ANLN
Anillin

1

1

High-throughput

0.479

High

539266

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

2

Small-scale

0.479

High

539267

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

539274

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

3

High-throughput

0.479

High

539275

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

539279

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

539280

SRRM2
Serine/arginine repetitive matrix protein 2

1

1

High-throughput

0.479

High

539149

RAP1B
Ras-related protein Rap-1b

1

1

High-throughput

0.464

High

61411

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66119

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

125180

LEG9
Galectin-9

1

0

High-throughput

0.458

High

350773

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

458254

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

459206

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

539124

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

539128

SYUA
Alpha-synuclein

1

0

Small-scale

0.458

High

539134

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

539157

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

539159

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

539161

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.458

High

539173

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

539178

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

539185

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

539190

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

539194

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

539208

MILK2
MICAL-like protein 2

1

0

High-throughput

0.458

High

539215

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

539223

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

539224

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

539228

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

539230

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

539237

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

539238

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

539239

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

539240

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

539244

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

539247

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

539248

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

539254

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

539255

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

539257

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

0

High-throughput

0.458

High

539263

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

539268

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

539269

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

539270

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

539271

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

539276

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

539282

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

85092

B7Z207
Protein-serine/threonine kinase

1

6

High-throughput

0.445

High

429196

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

539105

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

539188

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

539198

NEK10
Serine/threonine-protein kinase Nek10

1

6

High-throughput

0.445

High

539245

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.445

High

539284

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

105200

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

156888

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.437

High

208456

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.437

High

345300

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.437

High

539137

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.437

High

539146

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.437

High

539156

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.437

High

539182

PLEC
Plectin

1

2

High-throughput

0.437

High

539187

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.437

High

539189

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.437

High

539192

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

539196

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.437

High

539197

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

539206

GID4
Glucose-induced degradation protein 4 homolog

1

1

High-throughput

0.437

High

539209

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

539218

RND1
Rho-related GTP-binding protein Rho6

1

3

High-throughput

0.437

High

539226

KCD12
BTB/POZ domain-containing protein KCTD12

1

4

Small-scale

0.437

High

539251

RHOJ
Rho-related GTP-binding protein RhoJ

1

3

High-throughput

0.437

High

539253

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

539265

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

539272

WRP73
WD repeat-containing protein WRAP73

1

3

High-throughput

0.437

High

539111

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

539133

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

327761

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.407

High

539191

CP135
Centrosomal protein of 135 kDa

1

2

High-throughput

0.407

High

539214

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

539232

CK5P2
CDK5 regulatory subunit-associated protein 2

1

6

High-throughput

0.407

High

539281

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.407

High

431673

ITB1
Integrin beta-1

1

0

High-throughput

0.282

High

209455

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.279

Low

539139

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

539227

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

156002

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.269

Low

261760

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

539174

GRB7
Growth factor receptor-bound protein 7

1

0

High-throughput

0.265

Low

293115

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

539115

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.249

Low

539177

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

539210

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.249

Low

539278

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

539212

POC5
Centrosomal protein POC5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025