Protein: CSN3
COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)

Gene: CSN3, COPS3
Organism: Homo sapiens
Interactions: 198
UniProt ID: Q9UNS2

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0001701 - in utero embryonic development
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1272703

CSN5
COP9 signalosome complex subunit 5

16

20

Small-scale

0.986

High

1305361

CSN8
COP9 signalosome complex subunit 8

16

5

Small-scale

0.985

High

897331

CSN2
COP9 signalosome complex subunit 2

16

18

Small-scale

0.985

High

1024241

CSN1
COP9 signalosome complex subunit 1

16

20

Small-scale

0.985

High

1185012

CSN6
COP9 signalosome complex subunit 6

12

20

Small-scale

0.981

High

1354429

CSN7A
COP9 signalosome complex subunit 7a

13

18

Small-scale

0.980

High

1311917

CSN4
COP9 signalosome complex subunit 4

10

17

Small-scale

0.974

High

1334410

CSN7B
COP9 signalosome complex subunit 7b

10

18

Small-scale

0.974

High

1357580

CSN3
COP9 signalosome complex subunit 3

2

17

Small-scale

0.768

High

1043639

CUL4B
Cullin-4B

10

20

Small-scale

0.756

High

1043308

CUL4A
Cullin-4A

10

20

Small-scale

0.754

High

1042844

CUL3
Cullin-3

9

20

Small-scale

0.750

High

1082455

DDB1
DNA damage-binding protein 1

8

3

Small-scale

0.747

High

1263352

CSN9
COP9 signalosome complex subunit 9

6

3

Small-scale

0.737

High

1041503

CUL2
Cullin-2

6

20

Small-scale

0.733

High

1028037

ERCC8
DNA excision repair protein ERCC-8

6

7

Small-scale

0.728

High

1265915

DDB2
DNA damage-binding protein 2

5

8

Small-scale

0.714

High

1079187

STK11
Serine/threonine-protein kinase STK11

4

4

High-throughput

0.704

High

1255965

DCA11
DDB1- and CUL4-associated factor 11

4

4

High-throughput

0.694

High

1296811

LLR1
Leucine-rich repeat protein 1

4

2

High-throughput

0.694

High

1315087

BTBD2
BTB/POZ domain-containing protein 2

4

20

High-throughput

0.694

High

1327501

BTBD1
BTB/POZ domain-containing protein 1

4

20

High-throughput

0.694

High

1041281

CUL1
Cullin-1

4

20

Small-scale

0.691

High

1357585

DCAF1
DDB1- and CUL4-associated factor 1

4

5

Small-scale

0.676

High

1260957

DCAF4
DDB1- and CUL4-associated factor 4

3

5

High-throughput

0.667

High

1268473

APBP2
Amyloid protein-binding protein 2

3

3

High-throughput

0.667

High

1356310

FEM1B
Protein fem-1 homolog B

3

2

High-throughput

0.667

High

1274080

CUL5
Cullin-5

3

20

High-throughput

0.656

High

935845

HBB
Hemoglobin subunit beta

3

0

High-throughput

0.638

High

319422

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

3

High-throughput

0.628

High

1153800

KLH10
Kelch-like protein 10

2

15

High-throughput

0.628

High

1185104

DET1
DET1 homolog

2

2

High-throughput

0.628

High

1230768

FXL14
F-box/LRR-repeat protein 14

2

2

High-throughput

0.628

High

1356342

FBXL5
F-box/LRR-repeat protein 5

2

1

High-throughput

0.628

High

1357584

FBX7
F-box only protein 7

2

3

High-throughput

0.628

High

792094

HD
Huntingtin

2

2

High-throughput

0.621

High

158570

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

7

Small-scale

0.620

High

896261

UBC12
NEDD8-conjugating enzyme Ubc12

2

6

High-throughput

0.611

High

1065777

LRC14
Leucine-rich repeat-containing protein 14

2

3

High-throughput

0.611

High

1079635

NEDD8
NEDD8

2

5

Small-scale

0.611

High

1289624

FBX17
F-box only protein 17

2

6

High-throughput

0.611

High

1292406

DCNL1
DCN1-like protein 1

2

2

Small-scale

0.611

High

1297683

KLH15
Kelch-like protein 15

2

15

High-throughput

0.611

High

1344613

FBX6
F-box only protein 6

2

6

High-throughput

0.611

High

574775

ARF4
ADP-ribosylation factor 4

2

1

High-throughput

0.606

High

1284209

SOSB2
SOSS complex subunit B2

2

1

High-throughput

0.606

High

229065

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.601

High

360545

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

1

High-throughput

0.601

High

992503

SOS1
Son of sevenless homolog 1

1

1

Small-scale

0.586

High

156685

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

2

0

High-throughput

0.585

High

921478

RBX1
E3 ubiquitin-protein ligase RBX1

2

3

High-throughput

0.584

High

976530

ERCC6
DNA excision repair protein ERCC-6

2

3

Small-scale

0.584

High

1072484

ELOB
Elongin-B

2

2

High-throughput

0.584

High

1302576

CRBN
Protein cereblon

2

2

Small-scale

0.584

High

1314426

DDA1
DET1- and DDB1-associated protein 1

2

2

Small-scale

0.584

High

1349194

DTL
Denticleless protein homolog

2

6

Small-scale

0.584

High

207392

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.580

High

1154036

K2C80
Keratin, type II cytoskeletal 80

2

0

High-throughput

0.580

High

1244349

FAD1
FAD synthase

2

0

High-throughput

0.580

High

1252762

PXL2B
Prostamide/prostaglandin F synthase

2

0

High-throughput

0.580

High

1334801

NJMU
Protein Njmu-R1

2

0

High-throughput

0.580

High

375093

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

3

Small-scale

0.576

High

1039477

IRF5
Interferon regulatory factor 5

1

5

Small-scale

0.561

High

299535

KLH18
Kelch-like protein 18

2

15

High-throughput

0.558

High

497804

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.536

High

536557

IRF2
Interferon regulatory factor 2

1

5

High-throughput

0.536

High

813844

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

818609

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.536

High

943768

PRAME
Melanoma antigen preferentially expressed in tumors

1

3

High-throughput

0.536

High

1039944

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1075473

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

3

High-throughput

0.536

High

1123689

DCAF6
DDB1- and CUL4-associated factor 6

1

11

High-throughput

0.536

High

1148987

CYTSA
Cytospin-A

1

2

High-throughput

0.536

High

1234402

WDTC1
WD and tetratricopeptide repeats protein 1

1

10

High-throughput

0.536

High

1301999

NEB2
Neurabin-2

1

1

High-throughput

0.536

High

1309206

KLDC3
Kelch domain-containing protein 3

1

15

High-throughput

0.536

High

1346173

AP5S1
AP-5 complex subunit sigma-1

1

1

High-throughput

0.536

High

1347550

ASB6
Ankyrin repeat and SOCS box protein 6

1

2

High-throughput

0.536

High

1350341

KLHL8
Kelch-like protein 8

1

15

High-throughput

0.536

High

1202282

LCA5
Lebercilin

2

1

High-throughput

0.521

High

146653

SOCS2
Suppressor of cytokine signaling 2

1

2

High-throughput

0.515

High

722988

PGH2
Prostaglandin G/H synthase 2

1

1

Small-scale

0.515

High

1350562

WRP73
WD repeat-containing protein WRAP73

1

4

High-throughput

0.515

High

152057

TOR1A
Torsin-1A

1

5

High-throughput

0.515

High

218088

PEX1
Peroxisomal ATPase PEX1

1

3

High-throughput

0.515

High

456663

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

9

High-throughput

0.515

High

658615

HXD10
Homeobox protein Hox-D10

1

1

High-throughput

0.515

High

667732

NOS3
Nitric oxide synthase 3

1

2

High-throughput

0.515

High

742610

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

845355

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.515

High

1080936

SYUB
Beta-synuclein

1

2

High-throughput

0.515

High

1121143

GLE1
mRNA export factor GLE1

1

2

High-throughput

0.515

High

1153530

TTBK2
Tau-tubulin kinase 2

1

2

High-throughput

0.515

High

1353848

ATX10
Ataxin-10

1

1

High-throughput

0.515

High

1357583

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

60447

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.513

High

200437

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.513

High

1254314

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.513

High

1349370

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.513

High

1357582

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.513

High

488829

ARAF
Serine/threonine-protein kinase A-Raf

1

3

Small-scale

0.508

High

1357588

NEMO
NF-kappa-B essential modulator

1

0

Small-scale

0.506

High

1357581

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

1

Small-scale

0.506

High

476573

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

19

High-throughput

0.501

High

577512

IL1RA
Interleukin-1 receptor antagonist protein

1

1

Small-scale

0.501

High

934559

CSK21
Casein kinase II subunit alpha

1

7

Small-scale

0.501

High

388801

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

448138

DOPO
Dopamine beta-hydroxylase

1

0

High-throughput

0.493

High

642807

ELAV4
ELAV-like protein 4

1

0

High-throughput

0.493

High

660758

GRN
Progranulin

1

0

High-throughput

0.493

High

719658

MERL
Merlin

1

0

High-throughput

0.493

High

782011

PERI
Peripherin

1

0

High-throughput

0.493

High

782968

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.493

High

799463

ACY2
Aspartoacylase

1

0

High-throughput

0.493

High

821461

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.493

High

848162

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.493

High

870705

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

1051515

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.493

High

1189841

PEX26
Peroxisome assembly protein 26

1

0

High-throughput

0.493

High

1317676

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.493

High

207752

DENR
Density-regulated protein

1

2

High-throughput

0.489

High

1121813

ANR39
Ankyrin repeat domain-containing protein 39

1

4

High-throughput

0.489

High

1238370

SYT2
Synaptotagmin-2

1

2

High-throughput

0.489

High

1077842

CEBPE
CCAAT/enhancer-binding protein epsilon

1

6

Small-scale

0.481

High

931939

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.480

High

167634

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

8

Small-scale

0.479

High

201466

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.479

High

262621

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

295408

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

298889

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

348239

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

432367

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.479

High

504962

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

554057

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

639826

IKBA
NF-kappa-B inhibitor alpha

1

4

Small-scale

0.479

High

652607

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

717434

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

721781

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

780325

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

875434

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

885065

FBXW4
F-box/WD repeat-containing protein 4

1

7

Small-scale

0.479

High

885632

MLF1
Myeloid leukemia factor 1

1

3

Small-scale

0.479

High

905779

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

929123

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

967516

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

981934

RON
Macrophage-stimulating protein receptor

1

2

High-throughput

0.479

High

1036205

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1072330

ELOC
Elongin-C

1

1

High-throughput

0.479

High

1135857

DCAF8
DDB1- and CUL4-associated factor 8

1

12

High-throughput

0.479

High

1148872

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1172272

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

1174332

MOB3C
MOB kinase activator 3C

1

3

High-throughput

0.479

High

1244000

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1246202

COP1
E3 ubiquitin-protein ligase COP1

1

7

High-throughput

0.479

High

1262843

PHIP
PH-interacting protein

1

5

Small-scale

0.479

High

1267257

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

1269934

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1270733

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.479

High

1281878

FBX32
F-box only protein 32

1

4

High-throughput

0.479

High

1301000

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

1319032

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

6

High-throughput

0.479

High

1319131

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

1331631

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

1350235

IBTK
Inhibitor of Bruton tyrosine kinase

1

6

Small-scale

0.479

High

1350431

KLH42
Kelch-like protein 42

1

16

High-throughput

0.479

High

1354865

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1357586

MAFB
Transcription factor MafB

1

9

High-throughput

0.479

High

1243284

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

532651

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

739875

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.458

High

1054230

BECN1
Beclin-1

1

0

Small-scale

0.458

High

1330671

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

0

Small-scale

0.458

High

1335854

CENPJ
Centromere protein J

1

0

High-throughput

0.458

High

402623

JUN
Transcription factor Jun

1

8

High-throughput

0.445

High

1063132

ABRX2
BRISC complex subunit Abraxas 2

1

4

Small-scale

0.445

High

1120829

KLH12
Kelch-like protein 12

1

15

High-throughput

0.445

High

1130733

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1153455

PKHA7
Pleckstrin homology domain-containing family A member 7

1

7

High-throughput

0.445

High

1350484

KLH13
Kelch-like protein 13

1

15

High-throughput

0.445

High

181129

INSI1
Insulin-induced gene 1 protein

1

2

High-throughput

0.437

High

330018

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

354604

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

385721

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

1159470

FBX42
F-box only protein 42

1

10

High-throughput

0.437

High

1239009

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

5

Small-scale

0.437

High

1330717

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

1

High-throughput

0.437

High

1357587

INSI2
Insulin-induced gene 2 protein

1

2

High-throughput

0.437

High

1295618

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

831800

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

484922

GOG8G
Putative golgin subfamily A member 8G

1

1

High-throughput

0.407

High

1169475

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

1

High-throughput

0.407

High

396658

ITB2
Integrin beta-2

1

0

Small-scale

0.288

High

344594

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.268

Low

363662

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

429556

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

584101

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

1292002

BSCL2
Seipin

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024