HitPredict

Interactor 1: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Interactor 2: LITAF (Q99732)
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Gene: LITAF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	33093176, 25963657, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005794 - Golgi apparatus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 975 Hs			1 161
+	Mm
		808379 NEDD4_MOUSE (12-975): 0: 794: 55.19		LITAF_MOUSE (1-161): 7.43e-50: 159: 85.71
+	Hs
		1306061 WWP1_HUMAN (1-972): 0: 781: 33.13		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		1294843 ITCH_HUMAN (9-972): 0: 772: 33.16		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		808241 NEDD4_HUMAN (94-975): 0: 724: 49.78		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		125672 WWP2_HUMAN (228-972): 0: 719: 37.80		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		808268 NEDD4_HUMAN (94-975): 0: 724: 49.78		CDIP1_HUMAN (72-161): 2.31e-23: 93: 36.67
+	Hs
		1306072 HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Ce
		1276020 WWP1_CAEEL (16-344): 8.43e-11: 68: 16.50		Q94184_CAEEL (67-161): 9.08e-21: 84.9: 33.68