Protein: SPCS1
Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)

Gene: SPCS1
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q9Y6A9

Gene Ontology (top 5):
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0006508 - proteolysis
GO:0019068 - virion assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1136198

SPCS2
Signal peptidase complex subunit 2

2

0

High-throughput

0.748

High

956127

SPCS3
Signal peptidase complex subunit 3

2

0

High-throughput

0.736

High

1417786

SC11C
Signal peptidase complex catalytic subunit SEC11C

3

3

High-throughput

0.662

High

1248300

MOXD1
DBH-like monooxygenase protein 1

2

0

High-throughput

0.602

High

1458510

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

0

High-throughput

0.602

High

994970

SC11A
Signal peptidase complex catalytic subunit SEC11A

2

3

High-throughput

0.601

High

1491261

NALD2
N-acetylated-alpha-linked acidic dipeptidase 2

2

0

High-throughput

0.588

High

967369

TSN5
Tetraspanin-5

2

1

High-throughput

0.558

High

1411493

TM2D3
TM2 domain-containing protein 3

2

1

High-throughput

0.558

High

1419461

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

1

High-throughput

0.536

High

1453866

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

1461077

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

1

High-throughput

0.536

High

158371

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

535730

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.513

High

664092

PRTN3
Myeloblastin

1

0

High-throughput

0.513

High

699303

CALX
Calnexin

1

0

High-throughput

0.513

High

1032450

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.513

High

1084038

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

0

High-throughput

0.513

High

1110833

PKD2
Polycystin-2

1

0

High-throughput

0.513

High

1205513

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.513

High

1228792

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

High-throughput

0.513

High

1281285

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.513

High

1288314

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1365144

SL9A6
Sodium/hydrogen exchanger 6

1

0

High-throughput

0.513

High

1381373

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

1382264

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1382733

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

0

High-throughput

0.513

High

1402404

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.513

High

1437641

LMA1L
Protein ERGIC-53-like

1

0

High-throughput

0.513

High

1449035

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

0

High-throughput

0.513

High

1458856

CATF
Cathepsin F

1

0

High-throughput

0.513

High

1491824

TEST
Testisin

1

0

High-throughput

0.513

High

283730

GPC4
Glypican-4

1

1

High-throughput

0.489

High

762376

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

1

High-throughput

0.489

High

1121764

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.489

High

1217855

PR38B
Pre-mRNA-splicing factor 38B

1

1

High-throughput

0.489

High

1248940

ARSK
Arylsulfatase K

1

1

High-throughput

0.489

High

1388956

ARSG
Arylsulfatase G

1

1

High-throughput

0.489

High

1411109

BUD13
BUD13 homolog

1

2

High-throughput

0.489

High

1416625

TM2D2
TM2 domain-containing protein 2

1

1

High-throughput

0.489

High

1435782

AT133
Polyamine-transporting ATPase 13A3

1

1

High-throughput

0.489

High

1451205

SLTM
SAFB-like transcription modulator

1

1

High-throughput

0.489

High

1452683

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

2

High-throughput

0.489

High

374312

RASN
GTPase NRas

1

1

High-throughput

0.479

High

376157

RASK
GTPase KRas

1

1

High-throughput

0.479

High

466551

RHOC
Rho-related GTP-binding protein RhoC

1

3

High-throughput

0.479

High

581403

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

962686

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

1015950

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

122660

UBXN8
UBX domain-containing protein 8

1

0

High-throughput

0.460

High

1136429

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

1287484

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

High-throughput

0.458

High

1326962

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

1330456

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1352417

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.458

High

1448352

FBX6
F-box only protein 6

1

1

High-throughput

0.445

High

1460883

FBX2
F-box only protein 2

1

1

High-throughput

0.445

High

832666

AQP2
Aquaporin-2

1

2

Small-scale

0.439

High

126901

RHOD
Rho-related GTP-binding protein RhoD

1

5

High-throughput

0.437

High

1238867

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1392515

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1438278

RHOF
Rho-related GTP-binding protein RhoF

1

5

High-throughput

0.437

High

1431308

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.426

High

251328

NEMF
Ribosome quality control complex subunit NEMF

1

1

High-throughput

0.407

High

1048406

ACVR1
Activin receptor type-1

1

1

High-throughput

0.407

High

1236395

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.407

High

332727

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.347

High

1359338

SSMM1
Serine-rich single-pass membrane protein 1

3

0

High-throughput

0.345

High

880082

DNSL1
Deoxyribonuclease-1-like 1

3

0

High-throughput

0.339

High

761105

GBRA3
Gamma-aminobutyric acid receptor subunit alpha-3

2

0

High-throughput

0.328

High

1231724

PVRIG
Transmembrane protein PVRIG

2

0

High-throughput

0.318

High

256207

S19A2
Thiamine transporter 1

2

0

High-throughput

0.313

High

1323406

FXL14
F-box/LRR-repeat protein 14

2

0

High-throughput

0.313

High

175453

PLXB2
Plexin-B2

1

0

High-throughput

0.279

Low

230217

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.279

Low

238975

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.279

Low

248451

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

0

High-throughput

0.279

Low

284364

GEMI
Geminin

1

0

High-throughput

0.279

Low

338718

VNN2
Pantetheine hydrolase VNN2

1

0

High-throughput

0.279

Low

411142

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

High-throughput

0.279

Low

426040

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

0

High-throughput

0.279

Low

569155

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.279

Low

688718

NKG2D
NKG2-D type II integral membrane protein

1

0

High-throughput

0.279

Low

770442

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.279

Low

875849

PRC2A
Protein PRRC2A

1

0

High-throughput

0.279

Low

889359

NUMB
Protein numb homolog

1

0

High-throughput

0.279

Low

914384

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

931324

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.279

Low

1005522

RBM6
RNA-binding protein 6

1

0

High-throughput

0.279

Low

1008659

MAP1A
Microtubule-associated protein 1A

1

0

High-throughput

0.279

Low

1092397

TSN31
Tetraspanin-31

1

0

High-throughput

0.279

Low

1124443

ELOA1
Elongin-A

1

0

High-throughput

0.279

Low

1129401

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

High-throughput

0.279

Low

1150360

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

1

0

High-throughput

0.279

Low

1179046

HYAL4
Hyaluronidase-4

1

0

High-throughput

0.279

Low

1207467

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.279

Low

1208829

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.279

Low

1239992

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.279

Low

1270809

DDX46
Probable ATP-dependent RNA helicase DDX46

1

0

High-throughput

0.279

Low

1294440

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.279

Low

1316836

CA2D3
Voltage-dependent calcium channel subunit alpha-2/delta-3

1

0

High-throughput

0.279

Low

1327491

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.279

Low

1332866

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.279

Low

1337440

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.279

Low

1346575

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.279

Low

1351326

DMXL2
DmX-like protein 2

1

0

High-throughput

0.279

Low

1358233

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

1385280

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.279

Low

1385591

CSTOS
Protein CUSTOS

1

0

High-throughput

0.279

Low

1388565

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

High-throughput

0.279

Low

1389659

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.279

Low

1389746

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.279

Low

1393104

CREL1
Protein disulfide isomerase CRELD1

1

0

High-throughput

0.279

Low

1403002

IWS1
Protein IWS1 homolog

1

0

High-throughput

0.279

Low

1407405

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.279

Low

1415651

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.279

Low

1419749

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.279

Low

1420160

RTN4R
Reticulon-4 receptor

1

0

High-throughput

0.279

Low

1429596

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.279

Low

1432466

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1434472

ESF1
ESF1 homolog

1

0

High-throughput

0.279

Low

1446105

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

High-throughput

0.279

Low

1446238

NRN1
Neuritin

1

0

High-throughput

0.279

Low

1449138

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.279

Low

1450217

DCA13
DDB1- and CUL4-associated factor 13

1

0

High-throughput

0.279

Low

1454732

RBM27
RNA-binding protein 27

1

0

High-throughput

0.279

Low

1458941

ZO2
Tight junction protein 2

1

0

High-throughput

0.279

Low

1490971

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.279

Low

1491664

PCDG3
Protocadherin gamma-A3

1

0

High-throughput

0.279

Low

1491690

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

0

High-throughput

0.279

Low

1491823

WNT6
Protein Wnt-6

1

0

High-throughput

0.279

Low

420289

IGF1
Insulin-like growth factor 1

1

0

High-throughput

0.269

Low

183989

S22A2
Solute carrier family 22 member 2

1

0

Small-scale

0.251

Low

1382990

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.251

Low

1399080

TMM74
Transmembrane protein 74

1

0

High-throughput

0.251

Low

1416330

YIPF2
Protein YIPF2

1

0

High-throughput

0.251

Low

1430289

FXYD6
FXYD domain-containing ion transport regulator 6

1

0

High-throughput

0.251

Low

1449102

RPRM
Protein reprimo

1

0

High-throughput

0.251

Low

1491208

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.251

Low

219030

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

414933

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

799618

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

942990

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

947328

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

1005300

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1163454

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1450002

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1450153

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

217339

PROM1
Prominin-1

1

0

Small-scale

0.238

Low

1366335

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

1396473

BT2A3
Putative butyrophilin subfamily 2 member A3

1

0

High-throughput

0.232

Low

1436024

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025