HitPredict

Interactor 1: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Interactor 2: M3K20 (Q9NYL2)
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
Gene: MAP3K20

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19953087
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030154 - cell differentiation
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 975 Hs			1 800
+	Hs
		125761 WWP2_HUMAN (228-972): 0: 719: 37.80		M3K20_HUMAN (1-800): 0: 1246: 100.00
+	Hs
		789085 NED4L_HUMAN (1-975): 0: 1033: 100.00		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		337535 NED4L_HUMAN (1-975): 0: 1033: 100.00		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85
+	Hs
		789045 NEDD4_HUMAN (94-975): 0: 724: 49.78		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		337392 NEDD4_HUMAN (94-975): 0: 724: 49.78		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85
+	Hs
		433282 NEDD4_HUMAN (94-975): 0: 724: 49.78		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		337496 HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85
+	Hs
		945781 SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71		M3K9_HUMAN (7-326): 7.7e-116: 378: 38.91
+	Hs
		972468 SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66