HitPredict

Interactor 1: MAGI1 (Q96QZ7)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3)
Gene: MAGI1

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, Guanylate_kin~SH3_2, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0005923 - bicellular tight junction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1491 Hs			1 1190
+	Hs
		1232496 MAGI1_HUMAN (1-1491): 0: 756: 100.00		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Hs
		159190 DLG4_HUMAN (14-112): 3.09e-17: 89.9: 19.23		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Rn
		677805 NHRF3_RAT (990-1260): 1.99e-49: 186: 20.30		DLG4_RAT (3-423): 1.74e-52: 199: 18.89
+	Rn
		677779 GRIP1_RAT (14-838): 4.73e-25: 115: 10.56		DLG4_RAT (3-423): 1.74e-52: 199: 18.89
+	Mm
		1143518 MAGI3_MOUSE (4-484): 1.81e-18: 94.5: 11.62		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143467 DLG2_MOUSE (14-360): 2.17e-18: 93.7: 12.54		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		942349 DLG2_HUMAN (14-658): 7.28e-18: 92.2: 10.70		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Hs
		942321 DLG4_HUMAN (14-112): 3.09e-17: 89.9: 19.23		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		1143321 DLG4_MOUSE (14-110): 4.36e-17: 89.1: 19.61		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		1021501 DLG2_HUMAN (14-658): 7.28e-18: 92.2: 10.70		DLG1_HUMAN (1-515): 2.7e-47: 185: 16.38
+	Rn
		1144014 DLG2_RAT (14-360): 2.71e-18: 93.3: 12.26		DLG1_RAT (1-513): 8.04e-44: 174: 16.64
+	Mm
		1113136 DLG4_MOUSE (14-110): 4.36e-17: 89.1: 19.61		Q3UP61_MOUSE (8-513): 2.78e-44: 176: 16.28
+	Rn
		677787 DLG4_RAT (14-112): 2.35e-17: 90.2: 19.23		DLG1_RAT (1-513): 8.04e-44: 174: 16.64
+	Hs
		1077285 DLG2_HUMAN (14-658): 7.28e-18: 92.2: 10.70		DLG3_HUMAN (2-318): 5.99e-23: 107: 16.61
+	Hs
		942364 DLG4_HUMAN (14-112): 3.09e-17: 89.9: 19.23		DLG3_HUMAN (2-318): 5.99e-23: 107: 16.61
+	Mm
		1119795 DLG4_MOUSE (14-110): 4.36e-17: 89.1: 19.61		Q52KF7_MOUSE (2-318): 5.84e-23: 107: 16.61
+	Mm
		936188 DLG2_MOUSE (14-360): 2.17e-18: 93.7: 12.54		DLG3_MOUSE (372-595): 5.97e-13: 75.5: 18.10
+	Rn
		677790 DLG4_RAT (14-112): 2.35e-17: 90.2: 19.23		DLG3_RAT (372-595): 5.53e-13: 75.5: 18.10
+	Mm
		936180 DLG4_MOUSE (14-110): 4.36e-17: 89.1: 19.61		DLG3_MOUSE (372-595): 5.97e-13: 75.5: 18.10