HitPredict

Interactor 1: ELL2 (O00472)
RNA polymerase II elongation factor ELL2
Gene: ELL2

Interactor 2: CDK9 (P50750)
Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
Gene: CDK9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	21729782, 27684187, 32479599, 22483617, 21873227
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006368 - transcription elongation by RNA polymerase II GO:0008023 - transcription elongation factor complex GO:0032968 - positive regulation of transcription elongation by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 640 Hs			1 372
+	Mm
		1112829 ELL2_MOUSE (1-639): 0: 741: 90.31		CDK9_MOUSE (1-372): 2.88e-146: 420: 98.66
+	Hs
		841590 ELL_HUMAN (7-639): 0: 646: 45.92		CDK9_HUMAN (1-372): 2.88e-147: 422: 100.00
+	Hs
		841889 ELL3_HUMAN (26-275): 2.78e-31: 128: 21.22		CDK9_HUMAN (1-372): 2.88e-147: 422: 100.00
+	Dm
		184488 ELL_DROME (342-633): 1.51e-27: 120: 18.31		O17432_DROME (3-372): 3.74e-131: 382: 70.62
+	Hs
		624814 RPB1_HUMAN (421-543): 1.17e-10: 67.3: 13.01		CDK9_HUMAN (1-372): 2.88e-147: 422: 100.00
+	Mm
		444985 RPB1_MOUSE (421-543): 1.13e-10: 67.3: 13.01		CDK9_MOUSE (1-372): 2.88e-146: 420: 98.66
+	Hs
		625072 RPB1_HUMAN (421-543): 1.17e-10: 67.3: 13.01		CDK12_HUMAN (16-371): 1.16e-123: 390: 42.54