Protein: MED23
Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)

Gene: MED23
Organism: Homo sapiens
Interactions: 209
UniProt ID: Q9ULK4

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1174978

MED25
Mediator of RNA polymerase II transcription subunit 25

5

1

Small-scale

0.922

High

1356919

MED16
Mediator of RNA polymerase II transcription subunit 16

4

1

Small-scale

0.900

High

1301101

MED15
Mediator of RNA polymerase II transcription subunit 15

4

3

Small-scale

0.886

High

265375

MED24
Mediator of RNA polymerase II transcription subunit 24

2

0

High-throughput

0.778

High

826374

CDK8
Cyclin-dependent kinase 8

15

3

Small-scale

0.762

High

1076216

MED1
Mediator of RNA polymerase II transcription subunit 1

6

2

Small-scale

0.733

High

1314890

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

1312309

MED10
Mediator of RNA polymerase II transcription subunit 10

6

1

Small-scale

0.732

High

225435

MED14
Mediator of RNA polymerase II transcription subunit 14

5

3

Small-scale

0.720

High

48748

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.720

High

1312773

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.718

High

1274362

MED12
Mediator of RNA polymerase II transcription subunit 12

5

5

Small-scale

0.712

High

1355586

MED13
Mediator of RNA polymerase II transcription subunit 13

5

3

Small-scale

0.711

High

624531

CCNC
Cyclin-C

5

1

High-throughput

0.709

High

206661

MED7
Mediator of RNA polymerase II transcription subunit 7

4

1

High-throughput

0.699

High

1347853

MED29
Mediator of RNA polymerase II transcription subunit 29

4

1

High-throughput

0.699

High

1342945

MED4
Mediator of RNA polymerase II transcription subunit 4

4

1

Small-scale

0.699

High

1356920

MED31
Mediator of RNA polymerase II transcription subunit 31

4

1

High-throughput

0.694

High

1037114

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

High-throughput

0.691

High

270540

MED6
Mediator of RNA polymerase II transcription subunit 6

4

1

Small-scale

0.691

High

944633

ELF3
ETS-related transcription factor Elf-3

4

1

Small-scale

0.688

High

1348247

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.679

High

1346446

MED17
Mediator of RNA polymerase II transcription subunit 17

3

2

High-throughput

0.671

High

1061337

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

5

High-throughput

0.667

High

1291854

MED8
Mediator of RNA polymerase II transcription subunit 8

3

1

High-throughput

0.667

High

738998

SRBP1
Sterol regulatory element-binding protein 1

3

1

Small-scale

0.664

High

1328960

MED28
Mediator of RNA polymerase II transcription subunit 28

4

0

High-throughput

0.664

High

1347151

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.661

High

370690

ESR1
Estrogen receptor

3

4

Small-scale

0.660

High

1158933

MED27
Mediator of RNA polymerase II transcription subunit 27

3

2

High-throughput

0.656

High

1174787

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

3

High-throughput

0.656

High

1293710

MED30
Mediator of RNA polymerase II transcription subunit 30

3

1

Small-scale

0.656

High

1334014

MED20
Mediator of RNA polymerase II transcription subunit 20

3

0

High-throughput

0.649

High

313477

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.646

High

1269910

ESR2
Estrogen receptor beta

3

4

Small-scale

0.641

High

245084

BRD4
Bromodomain-containing protein 4

3

3

Small-scale

0.640

High

1349550

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.628

High

1206167

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

4

High-throughput

0.611

High

1310544

RIOK1
Serine/threonine-protein kinase RIO1

2

1

Small-scale

0.611

High

509994

VDR
Vitamin D3 receptor

2

2

Small-scale

0.595

High

1074737

MED22
Mediator of RNA polymerase II transcription subunit 22

2

0

High-throughput

0.585

High

570174

CEBPB
CCAAT/enhancer-binding protein beta

1

2

Small-scale

0.561

High

669069

PML
Protein PML

2

0

High-throughput

0.559

High

999204

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.554

High

1270837

CBP
CREB-binding protein

1

2

High-throughput

0.554

High

1302936

MINT
Msx2-interacting protein

1

1

High-throughput

0.554

High

232584

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.536

High

276218

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

2

High-throughput

0.536

High

613023

TCEA1
Transcription elongation factor A protein 1

1

1

High-throughput

0.536

High

803803

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.536

High

881335

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.536

High

903053

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.536

High

988035

RING1
E3 ubiquitin-protein ligase RING1

1

1

High-throughput

0.536

High

1032677

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.536

High

1044265

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.536

High

1085715

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.536

High

1222870

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.536

High

1235831

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.536

High

1272059

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.536

High

1290921

ZN503
Zinc finger protein 503

1

1

High-throughput

0.536

High

1302718

RBM15
RNA-binding protein 15

1

1

High-throughput

0.536

High

1333201

ZN703
Zinc finger protein 703

1

1

High-throughput

0.536

High

1356916

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

2

High-throughput

0.536

High

1356921

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

1

High-throughput

0.536

High

414398

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.530

High

987016

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.530

High

1268310

ZN516
Zinc finger protein 516

1

0

High-throughput

0.530

High

237633

DIAP1
Protein diaphanous homolog 1

1

0

High-throughput

0.513

High

587057

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

719225

PHB1
Prohibitin 1

1

0

High-throughput

0.513

High

771480

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.513

High

781480

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.513

High

800098

VDAC2
Voltage-dependent anion-selective channel protein 2

1

0

High-throughput

0.513

High

804371

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

894989

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.513

High

912129

RUXG
Small nuclear ribonucleoprotein G

1

0

High-throughput

0.513

High

925146

TRA2B
Transformer-2 protein homolog beta

1

0

High-throughput

0.513

High

958550

CYC
Cytochrome c

1

0

High-throughput

0.513

High

998217

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

1035217

ROCK1
Rho-associated protein kinase 1

1

0

High-throughput

0.513

High

1062802

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

1065593

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.513

High

1138235

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

0

High-throughput

0.513

High

1156083

HMBX1
Homeobox-containing protein 1

1

0

High-throughput

0.513

High

1160907

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1175244

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.513

High

1284995

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.513

High

1290667

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.513

High

1299412

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

1308623

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

1342572

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.513

High

1350570

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.513

High

1356485

RCOR1
REST corepressor 1

1

0

High-throughput

0.513

High

1356918

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.513

High

165102

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.489

High

172281

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

1052179

MAP7
Ensconsin

1

2

High-throughput

0.489

High

1059043

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

1

High-throughput

0.489

High

978933

TF65
Transcription factor p65

1

0

Small-scale

0.480

High

1356923

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

161474

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

1

High-throughput

0.479

High

266447

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

302038

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

455989

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.479

High

487833

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

782691

HNF4A
Hepatocyte nuclear factor 4-alpha

1

4

Small-scale

0.479

High

809014

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

897330

CSN2
COP9 signalosome complex subunit 2

1

1

Small-scale

0.479

High

941575

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

980908

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1057801

NCOA6
Nuclear receptor coactivator 6

1

1

Small-scale

0.479

High

1062895

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.479

High

1067187

BRD3
Bromodomain-containing protein 3

1

5

High-throughput

0.479

High

1070806

RBBP5
Retinoblastoma-binding protein 5

1

2

High-throughput

0.479

High

1073292

PUM3
Pumilio homolog 3

1

1

High-throughput

0.479

High

1075401

NCOA2
Nuclear receptor coactivator 2

1

2

High-throughput

0.479

High

1119945

EPC2
Enhancer of polycomb homolog 2

1

1

High-throughput

0.479

High

1132759

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

3

High-throughput

0.479

High

1154086

NIPBL
Nipped-B-like protein

1

2

Small-scale

0.479

High

1173275

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

1222638

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

1230902

ZN687
Zinc finger protein 687

1

1

High-throughput

0.479

High

1242693

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

4

Small-scale

0.479

High

1267976

ZN592
Zinc finger protein 592

1

1

High-throughput

0.479

High

1271510

KAT2B
Histone acetyltransferase KAT2B

1

4

High-throughput

0.479

High

1296856

EP400
E1A-binding protein p400

1

1

High-throughput

0.479

High

1306551

EPAS1
Endothelial PAS domain-containing protein 1

1

2

Small-scale

0.479

High

1329355

EPC1
Enhancer of polycomb homolog 1

1

1

High-throughput

0.479

High

317535

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.458

High

387719

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

501094

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

529902

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

554039

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

625094

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

637754

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.458

High

652588

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

721760

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

849282

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.458

High

906630

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

High-throughput

0.458

High

961318

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

974694

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

1076305

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1134088

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1189029

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1236566

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1240517

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.458

High

1243318

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.458

High

1273532

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.458

High

1281470

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1295206

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.458

High

1296439

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

0

Small-scale

0.458

High

1299707

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1300291

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.458

High

1301998

NEB2
Neurabin-2

1

0

High-throughput

0.458

High

1332197

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1345375

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

1346311

MRGBP
MRG/MORF4L-binding protein

1

0

High-throughput

0.458

High

1348908

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1356852

ZN608
Zinc finger protein 608

1

0

High-throughput

0.458

High

1356924

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.458

High

1234401

WDTC1
WD and tetratricopeptide repeats protein 1

1

1

Small-scale

0.457

High

73049

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

3

High-throughput

0.445

High

91318

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1271465

KAT2A
Histone acetyltransferase KAT2A

1

5

Small-scale

0.445

High

1356917

FOXJ3
Forkhead box protein J3

1

0

Small-scale

0.438

High

456250

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

1

Small-scale

0.437

High

1356922

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.426

High

1252137

PUM2
Pumilio homolog 2

1

1

Small-scale

0.417

High

542088

ETS1
Protein C-ets-1

1

1

Small-scale

0.408

High

831788

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

1334744

FBRS
Probable fibrosin-1

1

0

High-throughput

0.289

High

123760

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.279

Low

321669

AP2A1
AP-2 complex subunit alpha-1

1

0

High-throughput

0.279

Low

344724

CO3
Complement C3

1

0

High-throughput

0.279

Low

451982

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.279

Low

533256

PLSL
Plastin-2

1

0

High-throughput

0.279

Low

549929

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

0

High-throughput

0.279

Low

768489

CAP2
Adenylyl cyclase-associated protein 2

1

0

High-throughput

0.279

Low

778327

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

795335

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.279

Low

876090

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

890509

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.279

Low

1031114

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1086965

QPCT
Glutaminyl-peptide cyclotransferase

1

0

High-throughput

0.279

Low

1121347

AGK
Acylglycerol kinase, mitochondrial

1

0

High-throughput

0.279

Low

1184584

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

1251557

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.279

Low

1274636

KPBB
Phosphorylase b kinase regulatory subunit beta

1

0

High-throughput

0.279

Low

1284746

TTC28
Tetratricopeptide repeat protein 28

1

0

High-throughput

0.279

Low

1298541

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

1349511

CRIPT
Cysteine-rich PDZ-binding protein

1

0

High-throughput

0.279

Low

1349542

HACD3
Very-long-chain

1

0

High-throughput

0.279

Low

1350053

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

0

High-throughput

0.279

Low

1354048

GBG12

1

0

High-throughput

0.279

Low

1355819

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.279

Low

1356915

COR1C
Coronin-1C

1

0

High-throughput

0.279

Low

323294

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

329057

TCL1B
T-cell leukemia/lymphoma protein 1B

1

0

High-throughput

0.249

Low

385706

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

897855

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

1083618

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.249

Low

1172238

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1204002

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.249

Low

1205152

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

0

Small-scale

0.249

Low

1239343

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1331608

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1356914

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

354601

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.232

Low

1295614

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024