HitPredict

Interactor 1: ELL2 (O00472)
RNA polymerase II elongation factor ELL2
Gene: ELL2

Interactor 2: AFF1 (P51825)
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)
Gene: AFF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26496610, 21729782, 24367103
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AF-4~Occludin_ELL
Common GO terms	GO:0008023 - transcription elongation factor complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 640 Hs			1 1210
+	Hs
		850803 ELL_HUMAN (7-639): 0: 646: 45.92		AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00
+	Hs
		130172 ELL2_HUMAN (1-640): 0: 750: 100.00		AFF4_HUMAN (10-1208): 2.3e-90: 318: 34.44
+	Hs
		876672 ELL_HUMAN (7-639): 0: 646: 45.92		AFF4_HUMAN (10-1208): 2.3e-90: 318: 34.44
+	Hs
		130165 ELL2_HUMAN (1-640): 0: 750: 100.00		Q8TAX5_HUMAN (10-402): 2.53e-29: 123: 38.83
+	Hs
		850827 ELL3_HUMAN (26-275): 2.78e-31: 128: 21.22		AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00
+	Hs
		624818 RPB1_HUMAN (421-543): 1.17e-10: 67.3: 13.01		AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00
+	Hs
		1335107 ELL3_HUMAN (26-275): 2.78e-31: 128: 21.22		AFF4_HUMAN (10-1208): 2.3e-90: 318: 34.44
+	Rn
		94332 OCLN_RAT (408-635): 2.58e-70: 238: 22.41		F1M4A0_RAT (75-732): 2.06e-43: 175: 15.78
+	Mm
		761855 OCLN_MOUSE (408-635): 4.76e-69: 235: 21.58		ZO1_MOUSE (76-734): 7.98e-42: 170: 15.11
+	Hs
		297831 OCLN_HUMAN (408-635): 2.36e-68: 233: 20.08		K0754_HUMAN (277-807): 6.55e-29: 128: 12.75
+	Hs
		1084068 OCLN_HUMAN (408-635): 2.36e-68: 233: 20.08		MICA3_HUMAN (92-811): 7.34e-10: 65.8: 11.23
+	Dm
		1372607 ELL_DROME (342-633): 1.51e-27: 120: 18.31		AFFL_DROME (276-1210): 7.43e-31: 134: 16.27
+	Mm
		1351630 PCLO_MOUSE (174-516): 2.05e-09: 63.1: 7.89		PCLO_MOUSE (6-989): 7.06e-16: 85.9: 10.27
+	Hs
		152591 RPB1_HUMAN (421-543): 1.17e-10: 67.3: 13.01		KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13
+	Hs
		624899 RPB1_HUMAN (421-543): 1.17e-10: 67.3: 13.01		MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79
+	Hs
		1021422 ANK3_HUMAN (136-620): 1.04e-09: 64.2: 9.94		MICA3_HUMAN (92-811): 7.34e-10: 65.8: 11.23
+	Dm
		113976 M9PB30_DROME (247-538): 7.32e-09: 61.5: 12.70		M9PB30_DROME (27-449): 7.87e-09: 62.8: 10.82