HitPredict

Interactor 1: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.935

The method score is based on:

Property Details
Experiments 30018345, 30833792, 31980649, 10887201, 9020361, 9520446
Identification Methods affinity chromatography technology, enzymatic study, protein kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0001650 - fibrillar center
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
and 10 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 947
Hs

1 947
+ Hs
+ Hs
+ Hs
+ Rn
+ Mm
+ Hs
+ Hs
+ Rn
+ At
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024