Protein: PLK4
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)

Gene: PLK4
Organism: Homo sapiens
Interactions: 144
UniProt ID: O00444

Gene Ontology (top 5):
GO:0001741 - XY body
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

136023

PLK4
Serine/threonine-protein kinase PLK4

4

18

Small-scale

0.918

High

136066

DJB13
DnaJ homolog subfamily B member 13

2

7

High-throughput

0.783

High

136119

TET5B
Terminal nucleotidyltransferase 5B

2

3

High-throughput

0.783

High

136037

CE152
Centrosomal protein of 152 kDa

8

13

Small-scale

0.757

High

136068

ARP2
Actin-related protein 2

1

4

Small-scale

0.724

High

136025

ZBT39
Zinc finger and BTB domain-containing protein 39

2

1

High-throughput

0.700

High

136098

TET5C
Terminal nucleotidyltransferase 5C

1

3

High-throughput

0.698

High

136036

PPM1B
Protein phosphatase 1B

1

18

High-throughput

0.691

High

136052

IF4B
Eukaryotic translation initiation factor 4B

1

7

High-throughput

0.691

High

136078

RBM10
RNA-binding protein 10

1

9

High-throughput

0.691

High

136088

STK38
Serine/threonine-protein kinase 38

1

14

High-throughput

0.691

High

136089

SF3B3
Splicing factor 3B subunit 3

1

6

High-throughput

0.691

High

136090

SF3B4
Splicing factor 3B subunit 4

1

8

High-throughput

0.691

High

136155

ST38L
Serine/threonine-protein kinase 38-like

1

14

High-throughput

0.691

High

136091

STIL
SCL-interrupting locus protein

3

1

Small-scale

0.678

High

136154

FBW1A
F-box/WD repeat-containing protein 1A

3

11

Small-scale

0.658

High

136115

CE192
Centrosomal protein of 192 kDa

2

5

Small-scale

0.649

High

136054

1433T
14-3-3 protein theta

3

20

High-throughput

0.643

High

136056

1433S
14-3-3 protein sigma

2

20

High-throughput

0.637

High

136128

CAB45
45 kDa calcium-binding protein

1

15

High-throughput

0.618

High

136057

TTK
Dual specificity protein kinase TTK

1

17

High-throughput

0.618

High

136064

PLK1
Serine/threonine-protein kinase PLK1

1

17

High-throughput

0.618

High

136067

ARP3
Actin-related protein 3

1

3

Small-scale

0.618

High

136074

ACTS
Actin, alpha skeletal muscle

1

2

Small-scale

0.618

High

136085

FLII
Protein flightless-1 homolog

1

5

Small-scale

0.618

High

136086

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

7

Small-scale

0.618

High

136093

ACTBL
Beta-actin-like protein 2

1

2

Small-scale

0.618

High

136097

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

15

Small-scale

0.618

High

136102

MPRIP
Myosin phosphatase Rho-interacting protein

1

18

Small-scale

0.618

High

136109

MIB1
E3 ubiquitin-protein ligase MIB1

1

13

Small-scale

0.618

High

136114

NEK7
Serine/threonine-protein kinase Nek7

1

16

Small-scale

0.618

High

136142

RFOX1
RNA binding protein fox-1 homolog 1

1

10

High-throughput

0.618

High

136087

ELOA1
Elongin-A

3

5

High-throughput

0.616

High

136070

1433E
14-3-3 protein epsilon

2

11

High-throughput

0.611

High

136124

SPAG5
Sperm-associated antigen 5

2

19

High-throughput

0.606

High

136134

OSBL3
Oxysterol-binding protein-related protein 3

2

4

High-throughput

0.606

High

136146

TFP11
Tuftelin-interacting protein 11

2

1

High-throughput

0.606

High

136055

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.601

High

136069

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

136137

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

High-throughput

0.589

High

136080

1433F
14-3-3 protein eta

2

20

High-throughput

0.588

High

136136

ECT2
Protein ECT2

1

16

Small-scale

0.586

High

136096

CE350
Centrosome-associated protein 350

2

14

Small-scale

0.584

High

136100

CEP85
Centrosomal protein of 85 kDa

2

19

Small-scale

0.584

High

136101

SAS6
Spindle assembly abnormal protein 6 homolog

2

14

Small-scale

0.584

High

136111

NEDD1
Protein NEDD1

2

4

Small-scale

0.584

High

136113

ALMS1
Centrosome-associated protein ALMS1

2

7

Small-scale

0.584

High

136120

ENTR1
Endosome-associated-trafficking regulator 1

2

3

Small-scale

0.584

High

136121

CEP63
Centrosomal protein of 63 kDa

2

14

Small-scale

0.584

High

136041

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

136029

RFOX2
RNA binding protein fox-1 homolog 2

1

8

High-throughput

0.575

High

136079

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

1

High-throughput

0.574

High

136143

AIRIM
AFG2-interacting ribosome maturation factor

1

1

High-throughput

0.573

High

136138

CPAP
Centrosomal P4.1-associated protein

2

16

Small-scale

0.571

High

136141

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

Small-scale

0.561

High

136132

TRI54
Tripartite motif-containing protein 54

2

7

High-throughput

0.553

High

136047

POTEI
POTE ankyrin domain family member I

1

3

Small-scale

0.553

High

136082

NEXN
Nexilin

1

6

Small-scale

0.553

High

136024

TX1B3
Tax1-binding protein 3

1

4

High-throughput

0.541

High

136094

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

19

High-throughput

0.541

High

136032

ATP9A
Probable phospholipid-transporting ATPase IIA

1

3

High-throughput

0.536

High

136033

SF3B1
Splicing factor 3B subunit 1

1

8

High-throughput

0.536

High

136043

H2A1B
Histone H2A type 1-B/E

1

7

High-throughput

0.536

High

136050

H12
Histone H1.2

1

2

High-throughput

0.536

High

136060

TCPZ
T-complex protein 1 subunit zeta

1

6

High-throughput

0.536

High

136061

MAP1B
Microtubule-associated protein 1B

1

13

High-throughput

0.536

High

136072

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

136076

TCPB
T-complex protein 1 subunit beta

1

5

High-throughput

0.536

High

136077

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.536

High

136133

SKI8
Superkiller complex protein 8

1

9

High-throughput

0.536

High

136139

Q9HCK3
KIAA1569 protein

2

5

Small-scale

0.533

High

136059

ARRC
Arrestin-C

1

1

High-throughput

0.523

High

136130

DUS23
Dual specificity protein phosphatase 23

1

15

High-throughput

0.515

High

136045

PDIA1
Protein disulfide-isomerase

1

4

High-throughput

0.515

High

136065

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.513

High

136140

PLPL8
Calcium-independent phospholipase A2-gamma

1

0

High-throughput

0.513

High

136160

SPIN1
Spindlin-1

1

0

High-throughput

0.513

High

136084

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

9

High-throughput

0.508

High

136099

CP135
Centrosomal protein of 135 kDa

1

14

Small-scale

0.500

High

136063

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.489

High

136075

TBA1B
Tubulin alpha-1B chain

1

12

High-throughput

0.489

High

136153

SORC3
VPS10 domain-containing receptor SorCS3

1

1

High-throughput

0.489

High

136156

DCAF1
DDB1- and CUL4-associated factor 1

1

8

Small-scale

0.481

High

122665

KIF2A
Kinesin-like protein KIF2A

1

13

High-throughput

0.479

High

136026

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

8

Small-scale

0.479

High

136027

ARPC2
Actin-related protein 2/3 complex subunit 2

1

2

Small-scale

0.479

High

136030

TXNL1
Thioredoxin-like protein 1

1

6

Small-scale

0.479

High

136031

WDR1
WD repeat-containing protein 1

1

10

Small-scale

0.479

High

136034

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

7

High-throughput

0.479

High

136035

OFD1
Centriole and centriolar satellite protein OFD1

1

2

High-throughput

0.479

High

136038

PCNT
Pericentrin

1

18

High-throughput

0.479

High

136039

EYA4
Protein phosphatase EYA4

1

5

High-throughput

0.479

High

136040

CEP43
Centrosomal protein 43

1

1

Small-scale

0.479

High

136042

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

4

Small-scale

0.479

High

136044

GELS
Gelsolin

1

3

Small-scale

0.479

High

136046

H2AZ
Histone H2A.Z

1

11

Small-scale

0.479

High

136051

CXA1
Gap junction alpha-1 protein

1

1

Small-scale

0.479

High

136053

APC
Adenomatous polyposis coli protein

1

15

Small-scale

0.479

High

136058

SPRE
Sepiapterin reductase

1

1

High-throughput

0.479

High

136071

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

14

High-throughput

0.479

High

136073

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

14

High-throughput

0.479

High

136083

TWF1
Twinfilin-1

1

2

Small-scale

0.479

High

136095

FRPD1
FERM and PDZ domain-containing protein 1

1

1

Small-scale

0.479

High

136104

CE128
Centrosomal protein of 128 kDa

1

20

High-throughput

0.479

High

136116

HS105
Heat shock protein 105 kDa

1

11

High-throughput

0.479

High

136117

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

7

Small-scale

0.479

High

136118

FBXW5
F-box/WD repeat-containing protein 5

1

1

Small-scale

0.479

High

136123

H2A1A
Histone H2A type 1-A

1

7

Small-scale

0.479

High

136125

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.479

High

136127

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

136129

CP250
Centrosome-associated protein CEP250

1

13

High-throughput

0.479

High

136149

FBW1B
F-box/WD repeat-containing protein 11

1

11

High-throughput

0.479

High

136151

SYNP2
Synaptopodin-2

1

7

High-throughput

0.479

High

136152

CP131
Centrosomal protein of 131 kDa

1

13

High-throughput

0.479

High

136157

NDK7
Nucleoside diphosphate kinase homolog 7

1

3

Small-scale

0.479

High

136158

MAGD1
Melanoma-associated antigen D1

1

3

High-throughput

0.479

High

136028

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

Small-scale

0.458

High

136062

CAZA2
F-actin-capping protein subunit alpha-2

1

0

Small-scale

0.458

High

136081

CCD15
Coiled-coil domain-containing protein 15

1

0

High-throughput

0.458

High

136092

CSPP1
Centrosome and spindle pole-associated protein 1

1

0

High-throughput

0.458

High

136110

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

136150

SPAT2
Spermatogenesis-associated protein 2

1

0

Small-scale

0.458

High

136161

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

16

High-throughput

0.457

High

114477

H0Y9Y3
Synaptopodin 2

1

11

High-throughput

0.445

High

136106

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

6

High-throughput

0.445

High

435

A0A087WUI6
Progesterone immunomodulatory binding factor 1

1

0

High-throughput

0.438

High

136112

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.438

High

136103

FA83H
Protein FAM83H

1

1

High-throughput

0.437

High

136108

GA2L3
GAS2-like protein 3

1

5

Small-scale

0.437

High

136122

DOCK7
Dedicator of cytokinesis protein 7

1

7

High-throughput

0.437

High

136126

AIF1L
Allograft inflammatory factor 1-like

1

9

Small-scale

0.437

High

136144

TMOD2
Tropomodulin-2

1

2

Small-scale

0.437

High

136145

CING
Cingulin

1

10

Small-scale

0.437

High

136159

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

13

Small-scale

0.437

High

136048

AMY1B
Alpha-amylase 1B

1

3

High-throughput

0.407

High

136049

ACE
Angiotensin-converting enzyme

1

0

High-throughput

0.279

Low

66557

CC85C
Coiled-coil domain-containing protein 85C

1

0

Small-scale

0.249

Low

136105

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.249

Low

136107

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

Small-scale

0.249

Low

136131

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.249

Low

136135

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

Small-scale

0.249

Low

136147

GBG12

1

0

Small-scale

0.249

Low

136148

SH3L2
SH3 domain-binding glutamic acid-rich-like protein 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025