HitPredict

Interactor 1: PSDE (O00487)
26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1)
Gene: PSMD14

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	35509820, 35987950, 35256949, 23503661
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 310 Hs			1 465
+	Hs
		228258 CSN5_HUMAN (1-305): 6.24e-83: 255: 28.35		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		176889 EIF3H_HUMAN (23-298): 5.55e-55: 183: 21.05		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226157 STABP_HUMAN (17-199): 5.28e-44: 157: 17.84		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		130704 PSDE_HUMAN (1-310): 1.28e-110: 324: 100.00		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	Sc
		477336 RPN11_YEAST (1-310): 1.59e-93: 281: 64.84		UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72
+	Hs
		130705 PSDE_HUMAN (1-310): 1.28e-110: 324: 100.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1092172 PSDE_ARATH (1-309): 1.07e-109: 322: 79.61		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		476142 CSN5_HUMAN (1-305): 6.24e-83: 255: 28.35		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091793 CSN5A_ARATH (2-303): 1.72e-80: 249: 29.78		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Sc
		477501 CSN5_YEAST (14-282): 4.39e-45: 160: 24.11		UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72
+	Hs
		317702 STABP_HUMAN (17-199): 5.28e-44: 157: 17.84		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	At
		1091965 EIF3H_ARATH (7-304): 4.37e-72: 227: 18.61		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		474952 BRCC3_HUMAN (32-188): 1e-41: 148: 25.79		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	Hs
		176926 EIF3H_HUMAN (23-298): 5.55e-55: 183: 21.05		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091969 PSD7B_ARATH (15-256): 1.76e-49: 168: 18.43		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		188941 PSD7A_ARATH (15-256): 5.45e-49: 167: 18.04		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091838 AMSH1_ARATH (30-213): 1.94e-45: 162: 17.39		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		137953 EIF3F_ARATH (17-277): 2.76e-46: 159: 19.39		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		317703 STABP_HUMAN (17-199): 5.28e-44: 157: 17.84		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		476192 STALP_HUMAN (18-208): 4.08e-42: 152: 18.65		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47