Protein: RPB1
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (RNA polymerase II subunit A)

Gene: RPB1, Polr2A
Organism: Drosophila melanogaster
Interactions: 61
UniProt ID: P04052

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005665 - RNA polymerase II, core complex
GO:0005700 - polytene chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402251

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

20

Small-scale

0.737

High

122225

M9PHZ3
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

3

2

Small-scale

0.676

High

402256

TRX
Histone-lysine N-methyltransferase trithorax

1

12

Small-scale

0.618

High

402258

BRM
ATP-dependent helicase brm

1

8

Small-scale

0.618

High

402261

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

20

Small-scale

0.618

High

402290

Q9VXS6
IP08861p

1

7

High-throughput

0.618

High

402291

SET2
Histone-lysine N-methyltransferase Set2

1

10

Small-scale

0.618

High

402298

SPT6H
Transcription elongation factor SPT6

1

3

Small-scale

0.618

High

57197

DCR2
Endoribonuclease Dcr-2

2

6

Small-scale

0.584

High

402250

HP1
Heterochromatin protein 1

2

3

Small-scale

0.584

High

402264

NELFE
Negative elongation factor E

2

1

Small-scale

0.584

High

402267

Q32KD4
Protein argonaute-1

2

6

Small-scale

0.584

High

402275

Q9VCU6
Heterochromatin protein 1c

2

4

Small-scale

0.584

High

357030

O97183
DNA-directed RNA polymerase II subunit RPB3

1

19

High-throughput

0.575

High

402269

Q7JZF5
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

15

High-throughput

0.575

High

402255

TBP
TATA-box-binding protein

2

4

Small-scale

0.552

High

402273

Q9V3E9
RNA polymerase II-associated protein 3

2

7

Small-scale

0.521

High

402254

CI
Transcriptional activator cubitus interruptus

1

1

High-throughput

0.508

High

402276

Q9VEF5
Inhibitor of growth protein

1

1

High-throughput

0.508

High

402283

CDK12
Cyclin-dependent kinase 12

1

11

Small-scale

0.501

High

120163

M9PCJ7
Utx histone demethylase, isoform E

1

1

Small-scale

0.479

High

121964

M9PH39
histone acetyltransferase

1

7

Small-scale

0.479

High

145737

MOF
Histone acetyltransferase MOF

1

1

Small-scale

0.479

High

391865

HSP83
Heat shock protein 83

1

3

Small-scale

0.479

High

402257

MLE
Dosage compensation regulator mle

1

2

Small-scale

0.479

High

402259

PC
Polycomb group protein Pc

1

5

Small-scale

0.479

High

402262

T2FB
General transcription factor IIF subunit 2

1

2

High-throughput

0.479

High

402263

RB87F
Heterogeneous nuclear ribonucleoprotein 87F

1

1

Small-scale

0.479

High

402265

U2AF2
Splicing factor U2AF 50 kDa subunit

1

2

Small-scale

0.479

High

402268

YAP1
Transcriptional coactivator yorkie

1

11

High-throughput

0.479

High

402270

Q7KU01
Phosphatase 1 nuclear targeting subunit, isoform D

1

2

Small-scale

0.479

High

402277

TCTP
Translationally-controlled tumor protein homolog

1

1

Small-scale

0.479

High

402280

IF4A3
Eukaryotic initiation factor 4A-III

1

7

Small-scale

0.479

High

402284

Q9VPB7
FI17508p1

1

1

Small-scale

0.479

High

402285

KP58
Serine/threonine-protein kinase PITSLRE

1

8

Small-scale

0.479

High

402289

AGO2
Protein argonaute-2

1

6

Small-scale

0.479

High

402292

RENT1
Regulator of nonsense transcripts 1 homolog

1

5

Small-scale

0.479

High

402297

Q9W396
FI06908p

1

3

Small-scale

0.479

High

402299

INT6
Integrator complex subunit 6

1

1

Small-scale

0.479

High

402252

LAM0
Lamin Dm0

1

0

Small-scale

0.458

High

402274

Q9V9V7
LD23072p

1

0

Small-scale

0.458

High

402293

Q9VZJ3
GH01794p

1

0

Small-scale

0.458

High

402253

CRN
Protein crooked neck

1

6

High-throughput

0.445

High

402271

OSA
Trithorax group protein osa

1

1

High-throughput

0.445

High

402278

Q9VH81
protein-serine/threonine phosphatase

1

11

High-throughput

0.445

High

402279

Q9VHI1
Hyrax

1

2

Small-scale

0.445

High

402281

Q9VLS7
LD21067p

1

1

High-throughput

0.445

High

95077

E1JH68
Pre-mRNA cleavage complex 2 protein Pcf11

1

2

Small-scale

0.437

High

402296

Q9W1M9
Exosome complex component RRP4

1

2

Small-scale

0.437

High

402295

URI
Unconventional prefoldin RPB5 interactor-like protein

1

0

High-throughput

0.426

High

118749

M9NFI9
Neurabin-1

1

2

High-throughput

0.407

High

262711

TENM
Teneurin-m

1

1

High-throughput

0.407

High

402272

ENC
Protein encore

1

3

High-throughput

0.407

High

402282

Q9VN55
RNA polymerase II-associated factor 1 homolog

1

2

Small-scale

0.407

High

402294

Q9W0L7
ubiquitinyl hydrolase 1

1

4

High-throughput

0.407

High

402300

Q9W4M7
Twenty-four, isoform B

1

3

High-throughput

0.407

High

402288

CDK8
Cyclin-dependent kinase 8

1

12

High-throughput

0.381

High

402286

GOLP3
Golgi phosphoprotein 3 homolog sauron

1

0

High-throughput

0.249

Low

402287

CATIN
Splicing factor Cactin

1

0

Small-scale

0.249

Low

402260

FAS2
Fasciclin-2

1

0

High-throughput

0.232

Low

402266

NETB
Netrin-B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025