HitPredict

Interactor 1: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.800

Property	Details
Experiments	12672817, unassigned1973
Identification Methods	affinity chromatography technology, far western blotting, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH3_1~SH3_2, SH3_2~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 639
+	Hs
		1052363 SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1089312 RHG44_HUMAN (6-252): 2.28e-51: 184: 21.35		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1285180 SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1285181 SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Mm
		1143925 SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86		SH3K1_MOUSE (1-638): 2.12e-83: 278: 30.09
+	Hs
		1285179 SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1285230 SHLB1_HUMAN (10-347): 8.42e-72: 229: 24.50		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1066046 SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08		ARHG6_HUMAN (52-634): 3.49e-68: 239: 13.68
+	Hs
		1285199 SHLB2_HUMAN (10-347): 3.31e-62: 205: 21.35		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1089305 RHG44_HUMAN (6-252): 2.28e-51: 184: 21.35		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1148382 RHG17_HUMAN (6-256): 5.79e-38: 146: 21.56		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1066027 RHG44_HUMAN (6-252): 2.28e-51: 184: 21.35		ARHG6_HUMAN (52-634): 3.49e-68: 239: 13.68
+	Hs
		1078900 SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Rn
		192737 SH3G1_RAT (1-352): 4.69e-84: 261: 69.57		SRBS2_RAT (6-215): 1.07e-19: 96.2: 18.87
+	Hs
		1307421 SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		924570 SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924636 RHG17_HUMAN (6-256): 5.79e-38: 146: 21.56		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Xl
		60960 A5LHG3_XENLA (51-352): 8.55e-40: 152: 14.24		GRB2A_XENLA (2-169): 1.45e-35: 135: 18.34
+	Rn
		71363 SRC8_RAT (7-348): 4.32e-52: 181: 14.58		B2RZ33_RAT (113-378): 5.73e-21: 97.3: 14.24
+	Hs
		1148372 RHG17_HUMAN (6-256): 5.79e-38: 146: 21.56		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23