HitPredict

Interactor 1: PSDE (O00487)
26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1)
Gene: PSMD14

Interactor 2: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
Gene: PSMA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.740

Property	Details
Experiments	21733848, 24429290, 26496610, 27428775, 28821611, 35530310, 17323924
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 310 Hs			1 263
+	Dm
		522502 PSDE_DROME (1-310): 7.15e-114: 333: 88.39		PSA1_DROME (1-260): 4.06e-99: 292: 52.42
+	Dm
		1278634 PSDE_DROME (1-310): 7.15e-114: 333: 88.39		PSA5_DROME (1-237): 4.05e-92: 273: 28.86
+	Hs
		130644 PSDE_HUMAN (1-310): 1.28e-110: 324: 100.00		PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19
+	Hs
		130754 PSDE_HUMAN (1-310): 1.28e-110: 324: 100.00		PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81
+	Hs
		130824 PSDE_HUMAN (1-310): 1.28e-110: 324: 100.00		PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00
+	Hs
		130749 PSDE_HUMAN (1-310): 1.28e-110: 324: 100.00		PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75
+	Sp
		784781 RPN11_SCHPO (1-309): 7.37e-102: 302: 68.29		PSA5_SCHPO (1-239): 4.09e-94: 278: 34.82
+	Sp
		145195 RPN11_SCHPO (1-309): 7.37e-102: 302: 68.29		PSA6_SCHPO (1-261): 1.29e-92: 275: 53.82
+	Hs
		637505 CSN5_HUMAN (1-305): 6.24e-83: 255: 28.35		PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00
+	Hs
		156334 CSN5_HUMAN (1-305): 6.24e-83: 255: 28.35		PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19
+	Sc
		771336 RPN11_YEAST (1-310): 1.59e-93: 281: 64.84		PSA6_YEAST (1-233): 3.26e-83: 250: 52.77
+	Hs
		893720 CSN5_HUMAN (1-305): 6.24e-83: 255: 28.35		PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00
+	Dm
		611650 PSDE_DROME (1-310): 7.15e-114: 333: 88.39		PSA71_DROME (4-233): 2.4e-38: 136: 33.48
+	Mm
		643130 PSMD7_MOUSE (28-185): 2.4e-34: 129: 22.56		PSA1_MOUSE (1-263): 2.54e-109: 317: 98.10
+	Hs
		637362 PSMD7_HUMAN (28-185): 3.22e-34: 128: 22.56		PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00
+	Sp
		293712 RPN11_SCHPO (1-309): 7.37e-102: 302: 68.29		PSA2_SCHPO (4-215): 4.27e-36: 130: 36.28
+	Dm
		522480 PSMD7_DROME (27-185): 4.64e-35: 131: 23.03		PSA1_DROME (1-260): 4.06e-99: 292: 52.42
+	Dm
		640776 PSMD7_DROME (27-185): 4.64e-35: 131: 23.03		PSA5_DROME (1-237): 4.05e-92: 273: 28.86
+	Hs
		638089 PSMD7_HUMAN (28-185): 3.22e-34: 128: 22.56		PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75
+	Dm
		611629 PSMD7_DROME (27-185): 4.64e-35: 131: 23.03		PSA71_DROME (4-233): 2.4e-38: 136: 33.48