Protein: NFYC
Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2)

Gene: NFYC
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q13952

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

670077

NFYB
Nuclear transcription factor Y subunit beta

9

20

Small-scale

0.977

High

659679

NFYA
Nuclear transcription factor Y subunit alpha

9

20

Small-scale

0.976

High

1031896

NC2B
Protein Dr1

3

20

High-throughput

0.861

High

1085419

SRBP2
Sterol regulatory element-binding protein 2

3

2

High-throughput

0.861

High

371989

MYC
Myc proto-oncogene protein

2

3

Small-scale

0.815

High

1007918

PO6F2
POU domain, class 6, transcription factor 2

2

3

High-throughput

0.783

High

1119547

PO6F1
POU domain, class 6, transcription factor 1

2

3

High-throughput

0.783

High

892017

TAF6
Transcription initiation factor TFIID subunit 6

2

0

Small-scale

0.728

High

965448

LMO4
LIM domain transcription factor LMO4

3

3

High-throughput

0.667

High

1119571

POGZ
Pogo transposable element with ZNF domain

4

0

High-throughput

0.664

High

1119602

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.656

High

1034869

SP2
Transcription factor Sp2

3

8

High-throughput

0.653

High

629513

PO3F2
POU domain, class 3, transcription factor 2

1

5

Small-scale

0.647

High

626225

NFKB1
Nuclear factor NF-kappa-B p105 subunit

2

3

High-throughput

0.628

High

1119567

LIN54
Protein lin-54 homolog

3

0

High-throughput

0.625

High

617299

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

2

1

Small-scale

0.619

High

175886

SET1A
Histone-lysine N-methyltransferase SETD1A

1

2

High-throughput

0.618

High

1041519

KMT2A
Histone-lysine N-methyltransferase 2A

1

3

High-throughput

0.618

High

1109709

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.618

High

1119549

TAF5
Transcription initiation factor TFIID subunit 5

1

1

High-throughput

0.618

High

1119596

EP400
E1A-binding protein p400

1

4

High-throughput

0.618

High

1119615

CXXC1
CXXC-type zinc finger protein 1

1

1

High-throughput

0.618

High

1119562

ARID2
AT-rich interactive domain-containing protein 2

2

2

High-throughput

0.614

High

1119600

CIC
Protein capicua homolog

2

3

High-throughput

0.614

High

1119613

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

2

1

High-throughput

0.614

High

167263

KLF11
Krueppel-like factor 11

2

6

High-throughput

0.606

High

209997

CRX
Cone-rod homeobox protein

2

5

High-throughput

0.606

High

685187

PAX6
Paired box protein Pax-6

2

6

High-throughput

0.606

High

738979

ELF1
ETS-related transcription factor Elf-1

2

1

High-throughput

0.606

High

1036843

SP4
Transcription factor Sp4

2

10

High-throughput

0.606

High

1037716

PAX5
Paired box protein Pax-5

2

7

High-throughput

0.606

High

1119583

ZSCA1
Zinc finger and SCAN domain-containing protein 1

2

1

High-throughput

0.606

High

1119597

HSFY1
Heat shock transcription factor, Y-linked

2

1

High-throughput

0.606

High

1119618

KLF15
Krueppel-like factor 15

2

9

High-throughput

0.606

High

1119546

NUCG
Endonuclease G, mitochondrial

2

0

High-throughput

0.602

High

1119582

COMD1
COMM domain-containing protein 1

2

0

High-throughput

0.602

High

586295

ZEP1
Zinc finger protein 40

2

1

High-throughput

0.586

High

1119552

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

0

High-throughput

0.586

High

1119574

PB1
Protein polybromo-1

1

0

High-throughput

0.586

High

1119576

MGAP
MAX gene-associated protein

1

0

High-throughput

0.586

High

1119589

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.586

High

1119599

PHF12
PHD finger protein 12

1

0

High-throughput

0.586

High

1017696

PR20A
Proline-rich protein 20A

3

2

High-throughput

0.586

High

320679

UBXN7
UBX domain-containing protein 7

2

0

High-throughput

0.580

High

345178

ZMYM6
Zinc finger MYM-type protein 6

2

0

High-throughput

0.580

High

847992

RAD52
DNA repair protein RAD52 homolog

2

0

High-throughput

0.580

High

1119569

STOX1
Storkhead-box protein 1

2

0

High-throughput

0.580

High

1119581

CIART
Circadian-associated transcriptional repressor

2

0

High-throughput

0.580

High

1119617

SAE1
SUMO-activating enzyme subunit 1

2

0

High-throughput

0.580

High

690583

PON1
Serum paraoxonase/arylesterase 1

2

1

High-throughput

0.574

High

1119548

PON3
Serum paraoxonase/lactonase 3

2

1

High-throughput

0.574

High

1119563

USF3
Basic helix-loop-helix domain-containing protein USF3

1

0

High-throughput

0.560

High

186754

P73
Tumor protein p73

2

0

Small-scale

0.559

High

169549

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

3

High-throughput

0.553

High

1119595

KLD7B
Kelch domain-containing protein 7B

2

1

High-throughput

0.553

High

464954

SP1
Transcription factor Sp1

1

9

High-throughput

0.541

High

1119565

BICRL
BRD4-interacting chromatin-remodeling complex-associated protein-like

1

1

High-throughput

0.541

High

1119566

ADNP2
Activity-dependent neuroprotector homeobox protein 2

1

1

High-throughput

0.541

High

549320

SRF
Serum response factor

1

1

High-throughput

0.536

High

1029677

FOXK2
Forkhead box protein K2

1

9

High-throughput

0.536

High

1119614

FOXJ2
Forkhead box protein J2

1

7

High-throughput

0.536

High

1040288

DYST
Dystonin

1

0

High-throughput

0.518

High

1119557

Q3KNR5
PAX4 protein

1

6

High-throughput

0.515

High

347013

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

1119545

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.513

High

1119619

NXT1
NTF2-related export protein 1

1

0

High-throughput

0.513

High

408862

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.508

High

1017593

PR20E
Proline-rich protein 20E

2

2

High-throughput

0.504

High

628778

TBP
TATA-box-binding protein

1

2

Small-scale

0.501

High

1119550

TAF11
Transcription initiation factor TFIID subunit 11

1

2

Small-scale

0.501

High

1119553

TAF12
Transcription initiation factor TFIID subunit 12

1

2

Small-scale

0.501

High

1119603

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

1

Small-scale

0.501

High

1119573

MILR1
Allergin-1

1

2

High-throughput

0.489

High

213711

PAX4
Paired box protein Pax-4

1

6

High-throughput

0.481

High

1048507

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.479

High

130746

TAF4
Transcription initiation factor TFIID subunit 4

1

1

High-throughput

0.479

High

559759

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

4

High-throughput

0.479

High

606747

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

608972

XBP1
X-box-binding protein 1

1

4

Small-scale

0.479

High

667837

CDK2
Cyclin-dependent kinase 2

1

7

Small-scale

0.479

High

704470

MZF1
Myeloid zinc finger 1

1

1

Small-scale

0.479

High

871822

RFX5
DNA-binding protein RFX5

1

2

High-throughput

0.479

High

913769

ZN131
Zinc finger protein 131

1

2

High-throughput

0.479

High

913877

ZN143
Zinc finger protein 143

1

1

High-throughput

0.479

High

1014508

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.479

High

1106329

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

4

High-throughput

0.479

High

1119551

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.479

High

1119555

RFX7
DNA-binding protein RFX7

1

3

High-throughput

0.479

High

1119558

GON4L
GON-4-like protein

1

1

High-throughput

0.479

High

1119559

ARI4B
AT-rich interactive domain-containing protein 4B

1

3

High-throughput

0.479

High

1119572

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

3

High-throughput

0.479

High

1119586

ALMS1
Centrosome-associated protein ALMS1

1

1

High-throughput

0.479

High

1119591

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1119592

KAT2B
Histone acetyltransferase KAT2B

1

5

Small-scale

0.479

High

1119607

YYAP1
YY1-associated protein 1

1

1

High-throughput

0.479

High

1119616

KANL3
KAT8 regulatory NSL complex subunit 3

1

1

High-throughput

0.479

High

1119577

DDX60
Probable ATP-dependent RNA helicase DDX60

1

1

High-throughput

0.470

High

85454

B7ZLH0
FAM22F protein

1

1

High-throughput

0.470

High

1017633

PR20D
Proline-rich protein 20D

1

2

High-throughput

0.470

High

255424

SNX2
Sorting nexin-2

1

0

High-throughput

0.460

High

1119579

ZNF34
Zinc finger protein 34

1

0

High-throughput

0.460

High

130876

RFXAP
Regulatory factor X-associated protein

1

0

High-throughput

0.458

High

158438

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.458

High

247893

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

563741

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

Small-scale

0.458

High

571966

TRI27
Zinc finger protein RFP

1

0

Small-scale

0.458

High

1038619

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

0

High-throughput

0.458

High

1086209

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

1113066

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1119554

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

1119561

LIN9
Protein lin-9 homolog

1

0

High-throughput

0.458

High

1119568

NFRKB
Nuclear factor related to kappa-B-binding protein

1

0

High-throughput

0.458

High

1119570

ASXL2
Putative Polycomb group protein ASXL2

1

0

High-throughput

0.458

High

1119587

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1119594

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

0

High-throughput

0.458

High

1119608

KANL2
KAT8 regulatory NSL complex subunit 2

1

0

High-throughput

0.458

High

1119610

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1119611

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.458

High

51323

NTM2F
NUT family member 2F

1

1

High-throughput

0.439

High

553399

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

1

1

High-throughput

0.437

High

1119560

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1119609

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1119578

SMAP1
Stromal membrane-associated protein 1

2

0

High-throughput

0.316

High

1119580

AGRF5
Adhesion G protein-coupled receptor F5

2

0

High-throughput

0.316

High

1119584

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.316

High

1119585

CX038
Uncharacterized protein CXorf38

2

0

High-throughput

0.316

High

1119590

F168A
Protein FAM168A

2

0

High-throughput

0.316

High

1119606

DHRS6
Dehydrogenase/reductase SDR family member 6

2

0

High-throughput

0.316

High

437492

CASB
Beta-casein

1

0

High-throughput

0.282

High

1119575

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

1119556

CR1L
Complement component receptor 1-like protein

1

0

High-throughput

0.279

Low

1119564

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.279

Low

1119598

TGM7
Protein-glutamine gamma-glutamyltransferase Z

1

0

High-throughput

0.279

Low

1119620

KIF3A
Kinesin-like protein KIF3A

1

0

High-throughput

0.279

Low

1119605

Q9BRG6
APOL4 protein

1

0

High-throughput

0.268

Low

1119588

TITIN
Titin

1

0

High-throughput

0.261

Low

1119593

OSTF1
Osteoclast-stimulating factor 1

1

0

High-throughput

0.251

Low

1119604

APOL4
Apolipoprotein L4

1

0

High-throughput

0.251

Low

551739

COBA1

1

0

Small-scale

0.249

Low

643476

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.249

Low

867111

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.249

Low

1030236

FCERB
High affinity immunoglobulin epsilon receptor subunit beta

1

0

Small-scale

0.249

Low

1119601

METH
Methionine synthase

1

0

High-throughput

0.249

Low

1119612

ASND1
Asparagine synthetase domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025