HitPredict

Interactor 1: SYTL2 (Q99N50)
Synaptotagmin-like protein 2 (Exophilin-4)
Gene: SYTL2

Interactor 2: RB27A (Q9ERI2)
Ras-related protein Rab-27A (EC 3.6.5.2)
Gene: Rab27a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11773082
Identification Methods	coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0006887 - exocytosis GO:0042470 - melanosome GO:0070382 - exocytic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 950 Mm			1 221
+	Hs
		845952 SYTL2_HUMAN (1-950): 5.06e-152: 475: 80.88		RB27A_HUMAN (1-221): 3.76e-82: 245: 95.93
+	Hs
		119873 SYTL2_HUMAN (1-950): 5.06e-152: 475: 80.88		RB27B_HUMAN (1-221): 6e-78: 234: 71.95
+	Hs
		845927 SYTL3_HUMAN (530-940): 5.94e-108: 349: 29.37		RB27A_HUMAN (1-221): 3.76e-82: 245: 95.93
+	Hs
		119859 SYTL3_HUMAN (530-940): 5.94e-108: 349: 29.37		RB27B_HUMAN (1-221): 6e-78: 234: 71.95
+	Hs
		895496 SYTL3_HUMAN (530-940): 5.94e-108: 349: 29.37		RAB10_HUMAN (1-184): 1.04e-49: 162: 42.94
+	Hs
		1134943 SYT6_HUMAN (507-940): 9.28e-80: 270: 22.35		RAB1B_HUMAN (3-219): 2.96e-79: 237: 34.56
+	Hs
		896633 SYT6_HUMAN (507-940): 9.28e-80: 270: 22.35		RAB14_HUMAN (2-221): 5.51e-77: 232: 31.39
+	Hs
		599555 SYT1_HUMAN (610-941): 1.14e-73: 250: 25.67		RB27A_HUMAN (1-221): 3.76e-82: 245: 95.93
+	Mm
		1307906 SYTL1_MOUSE (1-204): 3.27e-62: 223: 31.31		RB27A_MOUSE (1-221): 3.76e-82: 245: 100.00
+	Hs
		845936 SYTL1_HUMAN (1-311): 3.33e-61: 220: 24.70		RB27A_HUMAN (1-221): 3.76e-82: 245: 95.93
+	Hs
		119861 SYTL1_HUMAN (1-311): 3.33e-61: 220: 24.70		RB27B_HUMAN (1-221): 6e-78: 234: 71.95
+	Mm
		1193404 SYTL5_MOUSE (1-791): 3.48e-51: 195: 14.50		RB27A_MOUSE (1-221): 3.76e-82: 245: 100.00
+	Hs
		845942 SYTL4_HUMAN (1-554): 1.36e-38: 155: 12.76		RB27A_HUMAN (1-221): 3.76e-82: 245: 95.93
+	Hs
		894765 SYTL1_HUMAN (1-311): 3.33e-61: 220: 24.70		RAB8A_HUMAN (6-187): 9.19e-54: 172: 46.70
+	Hs
		119867 SYTL4_HUMAN (1-554): 1.36e-38: 155: 12.76		RB27B_HUMAN (1-221): 6e-78: 234: 71.95
+	Hs
		914274 SYTL4_HUMAN (1-554): 1.36e-38: 155: 12.76		RB11A_HUMAN (3-220): 2.86e-77: 233: 34.84
+	Hs
		591484 SYTL4_HUMAN (1-554): 1.36e-38: 155: 12.76		RAB3A_HUMAN (2-192): 8.9e-57: 181: 43.98
+	Hs
		320135 SYTL4_HUMAN (1-554): 1.36e-38: 155: 12.76		RAB3D_HUMAN (2-190): 1.75e-56: 180: 43.92
+	Hs
		591654 SYTL4_HUMAN (1-554): 1.36e-38: 155: 12.76		RAB3B_HUMAN (2-190): 1.87e-54: 175: 43.92
+	Hs
		894790 SYTL4_HUMAN (1-554): 1.36e-38: 155: 12.76		RAB8A_HUMAN (6-187): 9.19e-54: 172: 46.70