Protein: VAC8
Vacuolar protein 8

Gene: VAC8
Organism: Saccharomyces cerevisiae S288C
Interactions: 100
UniProt ID: P39968

Gene Ontology (top 5):
GO:0000011 - vacuole inheritance
GO:0000045 - autophagosome assembly
GO:0000329 - fungal-type vacuole membrane
GO:0000407 - phagophore assembly site
GO:0000425 - pexophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

815965

VAC8
Vacuolar protein 8

4

15

Small-scale

0.908

High

816007

ATG13
Autophagy-related protein 13

9

0

Small-scale

0.726

High

806513

NVJ1
Nucleus-vacuole junction protein 1

6

0

Small-scale

0.712

High

677715

VAC17
vacuole-related protein 17

4

0

Small-scale

0.677

High

815972

PFA3
Palmitoyltransferase PFA3

3

1

Small-scale

0.651

High

815995

RAGAB
GTP-binding protein GTR1

2

1

High-throughput

0.608

High

779478

YKT6
Synaptobrevin homolog YKT6

2

1

Small-scale

0.602

High

579446

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.584

High

623864

MYO2
Myosin-2

2

5

Small-scale

0.576

High

816009

LAM6
Membrane-anchored lipid-binding protein LAM6

2

0

Small-scale

0.569

High

816011

TCO89
Target of rapamycin complex 1 subunit TCO89

2

0

Small-scale

0.569

High

816013

VAM3
Syntaxin VAM3

1

5

Small-scale

0.561

High

745211

COT1
Vacuolar zinc transporter COT1

1

4

High-throughput

0.541

High

807725

ATC2
Calcium-transporting ATPase 2

1

2

High-throughput

0.541

High

815981

JSN1
Protein JSN1

1

1

High-throughput

0.541

High

815982

IML1
Vacuolar membrane-associated protein IML1

1

6

High-throughput

0.541

High

816003

DPP1
Diacylglycerol pyrophosphate phosphatase 1

1

1

High-throughput

0.541

High

816018

ATG11
Autophagy-related protein 11

1

0

Small-scale

0.537

High

738652

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.536

High

815985

ATG1
Serine/threonine-protein kinase ATG1

1

9

Small-scale

0.536

High

571834

SNA3
Protein SNA3

1

0

High-throughput

0.518

High

777231

OSH1
Oxysterol-binding protein homolog 1

1

0

High-throughput

0.518

High

797839

FTH1
Iron transporter FTH1

1

0

High-throughput

0.518

High

811660

VATF
V-type proton ATPase subunit F

1

0

High-throughput

0.518

High

815997

MEH1
Protein MEH1

1

0

High-throughput

0.518

High

816008

SNA4
Protein SNA4

1

0

High-throughput

0.518

High

815993

ACT
Actin

1

10

Small-scale

0.515

High

737225

HXT1
Low-affinity glucose transporter HXT1

1

1

High-throughput

0.494

High

815969

RFC2
Replication factor C subunit 2

1

2

High-throughput

0.489

High

815990

BUD32
EKC/KEOPS complex subunit BUD32

1

0

Small-scale

0.486

High

815996

ACAC
Acetyl-CoA carboxylase

1

2

Small-scale

0.481

High

392779

HSP82
ATP-dependent molecular chaperone HSP82

1

9

High-throughput

0.479

High

646671

VPS15
Serine/threonine-protein kinase VPS15

1

8

High-throughput

0.479

High

649832

VPS34
Phosphatidylinositol 3-kinase VPS34

1

6

High-throughput

0.479

High

670745

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

673297

ADP1
Probable ATP-dependent permease

1

1

High-throughput

0.479

High

679718

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

693188

PHO91
Low-affinity phosphate transporter PHO91

1

1

High-throughput

0.479

High

727050

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

762823

TOR1
Serine/threonine-protein kinase TOR1

1

9

High-throughput

0.479

High

795365

ATG8
Autophagy-related protein 8

1

10

High-throughput

0.479

High

796491

PFF1
Vacuolar membrane protease

1

1

High-throughput

0.479

High

796942

PHO88
SRP-independent targeting protein 3

1

1

Small-scale

0.479

High

815862

KC13
Casein kinase I homolog 3

1

17

High-throughput

0.479

High

815967

VTC1
Vacuolar transporter chaperone complex subunit 1

1

3

High-throughput

0.479

High

815971

SYG1
Protein SYG1

1

1

High-throughput

0.479

High

815974

VTC2
Vacuolar transporter chaperone complex subunit 2

1

4

High-throughput

0.479

High

815975

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

10

High-throughput

0.479

High

815977

RMD8
Sporulation protein RMD8

1

1

High-throughput

0.479

High

815980

VTC4
Vacuolar transporter chaperone complex subunit 4

1

4

High-throughput

0.479

High

815983

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

815998

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

1

4

High-throughput

0.479

High

816000

RMD1
Sporulation protein RMD1

1

1

High-throughput

0.479

High

816001

SCC2
Sister chromatid cohesion protein 2

1

3

High-throughput

0.479

High

816010

MCA1
Metacaspase-1

1

1

High-throughput

0.479

High

816014

NYV1
Vacuolar v-SNARE NYV1

1

1

High-throughput

0.479

High

816019

YPK9
Vacuolar cation-transporting ATPase YPK9

1

3

High-throughput

0.479

High

740301

PAH1
Phosphatidic acid phosphohydrolase 1

1

0

Small-scale

0.460

High

815976

YFK5
Uncharacterized protein YFR035C

1

0

Small-scale

0.460

High

547054

PPB
Repressible alkaline phosphatase

1

0

High-throughput

0.458

High

645827

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.458

High

735724

VA0D
V-type proton ATPase subunit d

1

0

High-throughput

0.458

High

740063

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

High-throughput

0.458

High

747873

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

797177

ATG14
Autophagy-related protein 14

1

0

Small-scale

0.458

High

815973

VNX1
Low affinity vacuolar monovalent cation/H(+) antiporter

1

0

High-throughput

0.458

High

815988

VSB1
Vacuolar basic amino acid transporter VSB1

1

0

High-throughput

0.458

High

815999

BECN1
Vacuolar protein sorting-associated protein 30

1

0

High-throughput

0.458

High

816002

VTI1
t-SNARE VTI1

1

0

Small-scale

0.458

High

816016

YVC1
Calcium channel YVC1

1

0

High-throughput

0.458

High

816005

ERFB
Palmitoyltransferase ERF2

1

2

Small-scale

0.457

High

815989

RAGCD
GTP-binding protein GTR2

1

1

High-throughput

0.457

High

524041

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

526770

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

544977

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

815986

PIB2
Glutamine sensor PIB2

1

0

High-throughput

0.438

High

364553

CDK1
Cyclin-dependent kinase 1

1

9

High-throughput

0.437

High

510525

HSP77
Import motor subunit, mitochondrial

1

9

High-throughput

0.437

High

707178

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

815987

PESC
Pescadillo homolog

1

2

High-throughput

0.437

High

815991

HST2
NAD-dependent protein deacetylase HST2

1

12

High-throughput

0.437

High

815994

H3
Histone H3

1

9

High-throughput

0.437

High

816017

DBP10
ATP-dependent RNA helicase DBP10

1

7

High-throughput

0.437

High

816012

NCE2
Non-classical export protein 2

1

0

High-throughput

0.426

High

816015

PRR2
Serine/threonine-protein kinase PRR2

1

11

High-throughput

0.417

High

815979

JJJ2
J protein JJJ2

1

1

High-throughput

0.407

High

815966

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

4

0

Small-scale

0.360

High

815968

LDO16
Lipid droplet organization protein LDO16

2

0

Small-scale

0.310

High

815992

FMP41
Oxaloacetate tautomerase FMP41, mitochondrial

1

0

High-throughput

0.269

Low

506460

U5072
UPF0507 protein YML002W

1

0

Small-scale

0.251

Low

743866

YEF3
Uncharacterized protein YEL043W

1

0

Small-scale

0.251

Low

815970

TAO3
Cell morphogenesis protein PAG1

1

0

Small-scale

0.251

Low

816004

EAF1
Chromatin modification-related protein EAF1

1

0

Small-scale

0.251

Low

382912

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

748406

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

815984

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

776439

BLI1
Biogenesis of lysosome-related organelles complex 1 subunit BLI1

1

0

High-throughput

0.238

Low

816006

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.238

Low

815978

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025