HitPredict

Interactor 1: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Interactor 2: LZTS1 (Q9Y250)
Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)
Gene: LZTS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	26186194, 28514442, 29395067, 33961781, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 669 Hs			1 596
+	Hs
		230551 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		LZTS3_HUMAN (99-596): 3.57e-36: 145: 35.68
+	Hs
		1267534 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		TSC1_HUMAN (7-587): 1.97e-34: 141: 11.77
+	Rn
		655923 DCTN1_RAT (198-655): 6.79e-29: 125: 17.56		DCTN1_RAT (182-587): 4.93e-38: 152: 14.35
+	Hs
		1012570 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		CGNL1_HUMAN (203-595): 1.88e-11: 69.2: 14.71
+	Hs
		1268083 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		MY18A_HUMAN (240-536): 3.63e-11: 68.5: 12.58
+	Hs
		1145909 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		CP135_HUMAN (242-539): 1.03e-10: 66.8: 20.19
+	Hs
		551822 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		DESP_HUMAN (275-570): 1.97e-10: 66.5: 16.23
+	Hs
		724989 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		MYH9_HUMAN (154-534): 4.65e-10: 64.9: 12.04
+	Hs
		1377831 MTCL1_HUMAN (56-644): 5.72e-34: 141: 14.24		MTCL1_HUMAN (8-570): 1.12e-25: 115: 11.74
+	Hs
		61869 CC88B_HUMAN (60-668): 4.55e-16: 84.7: 12.48		TSC1_HUMAN (7-587): 1.97e-34: 141: 11.77
+	Hs
		165784 N4BP3_HUMAN (17-640): 5.23e-34: 139: 27.16		MYO5C_HUMAN (220-532): 9.56e-15: 80: 13.88
+	Hs
		1078828 ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88		ITSN1_HUMAN (1-580): 2.62e-20: 98.1: 12.58
+	Hs
		230542 LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62		CP135_HUMAN (242-539): 1.03e-10: 66.8: 20.19
+	Rn
		222472 MRCKA_RAT (185-663): 4.24e-19: 94.3: 11.02		MRCKA_RAT (329-596): 2.89e-17: 88: 17.83
+	Hs
		1268099 MYO5C_HUMAN (318-668): 7.57e-17: 87.4: 12.02		MY18A_HUMAN (240-536): 3.63e-11: 68.5: 12.58
+	Rn
		222476 MRCKA_RAT (185-663): 4.24e-19: 94.3: 11.02		MRCKB_RAT (170-510): 9.99e-09: 60.7: 11.40
+	Hs
		725035 MYO5C_HUMAN (318-668): 7.57e-17: 87.4: 12.02		MYH9_HUMAN (154-534): 4.65e-10: 64.9: 12.04
+	Dm
		404213 MYSA_DROME (329-654): 6.59e-14: 77.9: 14.65		MYSA_DROME (236-591): 5.96e-09: 61.6: 13.59