HitPredict

Interactor 1: EFC4B (Q9BSW2)
EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46)
Gene: CRACR2A

Interactor 2: PD1L1 (Q9NZQ7)
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Gene: CD274

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~V-set, Ras~V-set
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 731 Hs			1 290
+	Hs
		1166537 EFC4B_HUMAN (1-731): 8.94e-91: 301: 100.00		BTNL9_HUMAN (14-289): 1.23e-48: 171: 14.44
+	Hs
		1070425 RAB35_HUMAN (538-730): 3.7e-81: 258: 32.67		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		894820 RAB8A_HUMAN (538-727): 1.07e-79: 255: 37.90		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Mm
		919005 RAB1A_MOUSE (535-730): 1.67e-84: 267: 31.71		PD1L1_MOUSE (1-290): 2.5e-57: 187: 69.42
+	Mm
		895590 RAB10_MOUSE (546-730): 5.1e-83: 263: 36.65		PD1L1_MOUSE (1-290): 2.5e-57: 187: 69.42
+	Mm
		877202 RAB8A_MOUSE (538-727): 4.66e-79: 253: 37.90		PD1L1_MOUSE (1-290): 2.5e-57: 187: 69.42
+	Hs
		1070366 RAB35_HUMAN (538-730): 3.7e-81: 258: 32.67		PD1L2_HUMAN (19-259): 1.4e-52: 174: 38.43
+	Hs
		943925 RAB35_HUMAN (538-730): 3.7e-81: 258: 32.67		BT3A2_HUMAN (4-290): 2.39e-46: 160: 17.51
+	Hs
		1070483 RAB35_HUMAN (538-730): 3.7e-81: 258: 32.67		JAM1_HUMAN (2-290): 1.45e-40: 144: 15.46
+	Hs
		940426 RAB35_HUMAN (538-730): 3.7e-81: 258: 32.67		CXAR_HUMAN (3-281): 2.19e-39: 143: 16.67
+	Hs
		1070491 RAB35_HUMAN (538-730): 3.7e-81: 258: 32.67		ROBO1_HUMAN (10-235): 9.63e-31: 123: 15.45
+	Mm
		1322201 RAB13_MOUSE (541-704): 3.69e-42: 154: 43.90		PD1L1_MOUSE (1-290): 2.5e-57: 187: 69.42
+	Hs
		530172 RAB35_HUMAN (538-730): 3.7e-81: 258: 32.67		NCAM1_HUMAN (140-265): 2.35e-13: 72.2: 18.32
+	Hs
		793318 RAB35_HUMAN (538-730): 3.7e-81: 258: 32.67		MUC18_HUMAN (20-245): 2.36e-12: 69.1: 17.17
+	Hs
		845860 RAB13_HUMAN (541-704): 9.47e-42: 152: 42.68		BTNL9_HUMAN (14-289): 1.23e-48: 171: 14.44
+	Hs
		130185 RAB13_HUMAN (541-704): 9.47e-42: 152: 42.68		BT3A3_HUMAN (3-289): 7.81e-46: 164: 18.52
+	Hs
		591543 RAB3B_HUMAN (535-702): 8.54e-41: 150: 43.45		CXAR_HUMAN (3-281): 2.19e-39: 143: 16.67
+	Hs
		793239 RAB13_HUMAN (541-704): 9.47e-42: 152: 42.68		MUC18_HUMAN (20-245): 2.36e-12: 69.1: 17.17