HitPredict

Interactor 1: BIN1 (O00499)
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)
Gene: BIN1

Interactor 2: SYN1 (P17600)
Synapsin-1 (Brain protein 4.1) (Synapsin I)
Gene: SYN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10899172
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008021 - synaptic vesicle GO:0030424 - axon GO:0030425 - dendrite GO:0098850 - extrinsic component of synaptic vesicle membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 705
+	Hs
		568502 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		SYN1_HUMAN (1-705): 2.23e-169: 504: 100.00
+	Hs
		568524 ITSN2_HUMAN (2-593): 2.37e-12: 72.5: 11.45		SYN1_HUMAN (1-705): 2.23e-169: 504: 100.00
+	Dm
		112573 M9ND00_DROME (322-591): 2.06e-32: 135: 16.49		SYN_DROME (60-666): 9.17e-127: 403: 33.28
+	Hs
		131265 BIN1_HUMAN (1-593): 1.03e-133: 404: 100.00		RIN3_HUMAN (331-697): 1.74e-23: 108: 13.47
+	Rn
		139991 BIN1_RAT (1-592): 2.1e-127: 388: 93.59		SYNJ1_RAT (336-704): 6e-10: 65: 13.91
+	Hs
		846969 SRC8_HUMAN (14-591): 1.39e-77: 257: 16.72		SMCA4_HUMAN (369-705): 1.59e-23: 108: 15.92
+	Hs
		1167810 DNMBP_HUMAN (17-591): 7.98e-54: 200: 16.93		RIN3_HUMAN (331-697): 1.74e-23: 108: 13.47
+	Hs
		1167826 DNMBP_HUMAN (17-591): 7.98e-54: 200: 16.93		PTN23_HUMAN (336-691): 3.68e-20: 98.1: 16.75
+	Hs
		203213 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		SYNJ1_HUMAN (290-705): 2.31e-41: 165: 16.89
+	Hs
		1251926 BIN3_HUMAN (32-289): 1.84e-34: 132: 16.73		RIN3_HUMAN (331-697): 1.74e-23: 108: 13.47
+	Hs
		203228 ITSN1_HUMAN (3-591): 1.85e-11: 69.4: 13.69		SYNJ1_HUMAN (290-705): 2.31e-41: 165: 16.89
+	Hs
		66539 A8K5Y2_HUMAN (44-592): 1.37e-21: 101: 15.13		RIN3_HUMAN (331-697): 1.74e-23: 108: 13.47
+	Hs
		1251932 ITSN2_HUMAN (2-593): 2.37e-12: 72.5: 11.45		RIN3_HUMAN (331-697): 1.74e-23: 108: 13.47
+	Hs
		1078907 ITSN1_HUMAN (3-591): 1.85e-11: 69.4: 13.69		PTN23_HUMAN (336-691): 3.68e-20: 98.1: 16.75
+	Rn
		139978 AMPH_RAT (44-592): 1.56e-19: 94.9: 16.52		SYNJ1_RAT (336-704): 6e-10: 65: 13.91
+	Hs
		257713 ITSN2_HUMAN (2-593): 2.37e-12: 72.5: 11.45		ANR17_HUMAN (380-654): 5.65e-09: 61.9: 12.73
+	Mm
		1351630 PCLO_MOUSE (267-550): 8.57e-12: 70.9: 13.24		PCLO_MOUSE (329-705): 4.41e-09: 62.3: 13.32
+	Dm
		113976 M9PB30_DROME (284-522): 2.63e-10: 65.9: 14.29		M9PB30_DROME (335-700): 7.49e-09: 61.5: 7.16