Protein: CLIC1
Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC)

Gene: CLIC1
Organism: Homo sapiens
Interactions: 128
UniProt ID: O00299

Gene Ontology (top 5):
GO:0005254 - chloride channel activity
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

131117

CFTR
Cystic fibrosis transmembrane conductance regulator

4

1

High-throughput

0.700

High

131174

TPRN
Taperin

4

3

High-throughput

0.698

High

131088

LSM1
U6 snRNA-associated Sm-like protein LSm1

4

0

Small-scale

0.661

High

131091

PRKN
E3 ubiquitin-protein ligase parkin

3

5

High-throughput

0.640

High

131204

ANLN
Anillin

3

0

High-throughput

0.628

High

131203

SDF2L
Stromal cell-derived factor 2-like protein 1

2

0

High-throughput

0.602

High

131095

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

1

Small-scale

0.597

High

131093

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

131098

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

131182

PRSR2
Proline and serine-rich protein 2

2

1

High-throughput

0.574

High

131102

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

131172

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

131176

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

High-throughput

0.571

High

131112

TPC2B
Trafficking protein particle complex subunit 2B

1

1

Small-scale

0.552

High

131124

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

131113

THA
Thyroid hormone receptor alpha

1

2

High-throughput

0.541

High

131195

ZN184
Zinc finger protein 184

1

2

High-throughput

0.541

High

131206

ZN302
Zinc finger protein 302

1

1

High-throughput

0.541

High

131211

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.541

High

131089

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.536

High

131100

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.536

High

131119

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.536

High

131205

MYO5C
Unconventional myosin-Vc

1

2

High-throughput

0.536

High

131185

SH2D3
SH2 domain-containing protein 3C

2

4

High-throughput

0.521

High

131109

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.518

High

131125

AL5AP
Arachidonate 5-lipoxygenase-activating protein

1

0

High-throughput

0.518

High

131127

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.518

High

131130

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.518

High

131135

NTF4
Neurotrophin-4

1

0

High-throughput

0.518

High

131142

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.518

High

131152

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

High-throughput

0.518

High

131191

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.518

High

131179

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

48870

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.513

High

131086

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

131134

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

131138

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.513

High

131141

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.513

High

131147

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.513

High

131148

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

131184

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

131210

HPSE
Heparanase

1

0

High-throughput

0.513

High

131151

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.481

High

131164

PRDX4
Peroxiredoxin-4

1

4

High-throughput

0.481

High

131087

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.479

High

131096

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

131097

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

131101

FINC
Fibronectin

1

3

High-throughput

0.479

High

131103

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

131106

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

131108

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

131111

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

131114

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

131115

EPB41
Protein 4.1

1

2

High-throughput

0.479

High

131120

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

131123

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

131126

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

131128

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

131129

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.479

High

131131

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

131132

CDC27
Cell division cycle protein 27 homolog

1

1

Small-scale

0.479

High

131133

CCND2
G1/S-specific cyclin-D2

1

1

Small-scale

0.479

High

131136

GRK5
G protein-coupled receptor kinase 5

1

1

High-throughput

0.479

High

131137

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

1

High-throughput

0.479

High

131140

HNF1B
Hepatocyte nuclear factor 1-beta

1

1

High-throughput

0.479

High

131146

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

131153

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

131154

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

131156

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

131157

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

131169

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.479

High

131171

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

131180

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

131187

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.479

High

131188

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.479

High

131189

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

131190

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

131200

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

131208

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

131209

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

131197

MYOC
Myocilin

1

0

Small-scale

0.460

High

131090

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

131092

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

131094

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.458

High

131099

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

131116

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

131118

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

131121

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

131122

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

131143

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

131149

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

131158

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.458

High

131159

VIGLN
Vigilin

1

0

High-throughput

0.458

High

131161

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

131165

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

131166

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

131168

CUL7
Cullin-7

1

0

High-throughput

0.458

High

131170

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

131173

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

131178

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

131181

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

131183

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

131194

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

131196

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

131198

AKAP9
A-kinase anchor protein 9

1

0

Small-scale

0.458

High

131199

MEP50
Methylosome protein WDR77

1

0

High-throughput

0.458

High

131202

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

131207

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

131105

PRIO
Major prion protein

1

1

High-throughput

0.445

High

131110

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

131160

E2F1
Transcription factor E2F1

1

1

High-throughput

0.445

High

131162

TAGL
Transgelin

1

4

High-throughput

0.445

High

131163

LG3BP
Galectin-3-binding protein

1

1

High-throughput

0.445

High

131144

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.438

High

104805

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

131139

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

131167

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

131177

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

131186

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

1

Small-scale

0.437

High

131193

LMTK3
Serine/threonine-protein kinase LMTK3

1

4

High-throughput

0.437

High

131107

IPSP
Plasma serine protease inhibitor

1

0

Small-scale

0.426

High

131145

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.426

High

131155

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

131192

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

131201

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

0

High-throughput

0.426

High

131104

ANXA1
Annexin A1

1

4

Small-scale

0.408

High

131150

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

131175

NHSL2
NHS-like protein 2

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025