HitPredict

Interactor 1: BIN1 (O00499)
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)
Gene: BIN1

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	32203420, 9182529, unassigned2213
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PH~SH3_9, RhoGEF~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 1333
+	Hs
		131241 BIN1_HUMAN (1-593): 1.03e-133: 404: 100.00		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		992496 ITSN2_HUMAN (2-593): 2.37e-12: 72.5: 11.45		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		992477 ITSN1_HUMAN (3-591): 1.85e-11: 69.4: 13.69		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		992521 ITSN2_HUMAN (2-593): 2.37e-12: 72.5: 11.45		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		992508 ITSN1_HUMAN (3-591): 1.85e-11: 69.4: 13.69		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		156402 DNMBP_HUMAN (17-591): 7.98e-54: 200: 16.93		RGRF2_HUMAN (360-991): 7.8e-85: 305: 17.89
+	Hs
		1078876 ITSN1_HUMAN (3-591): 1.85e-11: 69.4: 13.69		PREX1_HUMAN (194-567): 2.78e-94: 337: 21.98
+	Mm
		1322315 PCLO_MOUSE (267-550): 8.57e-12: 70.9: 13.24		RPGF4_MOUSE (465-1021): 3.13e-84: 300: 15.76
+	Hs
		279897 ITSN2_HUMAN (2-593): 2.37e-12: 72.5: 11.45		TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83