Protein: HTRA1
Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11)

Gene: HTRA1
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q92743

Gene Ontology (top 5):
GO:0001890 - placenta development
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1367853

HTRA1
Serine protease HTRA1

5

18

Small-scale

0.930

High

1367858

REG4
Regenerating islet-derived protein 4

2

2

High-throughput

0.811

High

731886

CEAM8
Cell adhesion molecule CEACAM8

1

1

High-throughput

0.691

High

1013317

HTRA4
Serine protease HTRA4

1

17

Small-scale

0.691

High

1295019

TMM25
Transmembrane protein 25

4

1

High-throughput

0.691

High

1030806

DEF5
Defensin alpha 5

3

1

High-throughput

0.662

High

530157

TAU
Microtubule-associated protein tau

3

0

Small-scale

0.643

High

1022758

XIAP
E3 ubiquitin-protein ligase XIAP

2

15

Small-scale

0.619

High

252219

ISK4
Serine protease inhibitor Kazal-type 4

2

0

High-throughput

0.602

High

377039

NEU2
Vasopressin-neurophysin 2-copeptin

2

0

High-throughput

0.602

High

624204

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

2

0

High-throughput

0.602

High

1367859

DB127
Beta-defensin 127

2

0

High-throughput

0.602

High

159775

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.586

High

1132051

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

9

Small-scale

0.536

High

1367862

OPT
Opticin

1

5

High-throughput

0.536

High

570944

MIF
Macrophage migration inhibitory factor

1

0

Small-scale

0.529

High

465855

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.513

High

1099634

NOGG
Noggin

1

0

High-throughput

0.513

High

1249602

ALKL2
ALK and LTK ligand 2

1

0

High-throughput

0.513

High

1332792

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.513

High

1367864

DKKL1
Dickkopf-like protein 1

1

0

High-throughput

0.513

High

1367868

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

422765

A4
Amyloid-beta precursor protein

1

1

Small-scale

0.501

High

713122

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.486

High

995178

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.481

High

218573

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

970864

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1008019

JAG1
Protein jagged-1

1

3

Small-scale

0.479

High

387447

APOE
Apolipoprotein E

1

0

High-throughput

0.460

High

635356

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.460

High

1367869

PCDBF
Protocadherin beta-15

1

0

High-throughput

0.458

High

131485

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

1

Small-scale

0.457

High

384187

CO1A1
Collagen alpha-1(I) chain

1

1

Small-scale

0.457

High

654542

FBLN1
Fibulin-1

1

10

Small-scale

0.457

High

955443

CDC42
Cell division control protein 42 homolog

1

1

Small-scale

0.457

High

1118544

TBB2A
Tubulin beta-2A chain

1

4

Small-scale

0.457

High

1367856

LZTS2
Leucine zipper putative tumor suppressor 2

1

3

Small-scale

0.457

High

1367865

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

2

Small-scale

0.457

High

464464

TSP1
Thrombospondin-1

1

2

Small-scale

0.445

High

942790

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

1086430

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

9

Small-scale

0.445

High

1104625

IKZF1
DNA-binding protein Ikaros

1

1

High-throughput

0.445

High

1346748

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

1

High-throughput

0.445

High

1367854

TET5A
Terminal nucleotidyltransferase 5A

1

1

High-throughput

0.439

High

890867

TSC2
Tuberin

1

0

Small-scale

0.438

High

1367866

CTND2
Catenin delta-2

1

0

Small-scale

0.438

High

1254892

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1367861

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.437

High

987812

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.426

High

1150365

BGH3
Transforming growth factor-beta-induced protein ig-h3

1

0

Small-scale

0.426

High

360451

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.417

High

907977

DYLT3
Dynein light chain Tctex-type 3

1

1

Small-scale

0.417

High

1216336

Q5TF85
polynucleotide adenylyltransferase

1

1

High-throughput

0.417

High

1148368

KS6A1
Ribosomal protein S6 kinase alpha-1

1

0

Small-scale

0.391

High

1367860

SPRNG
SREBP regulating gene protein

2

0

High-throughput

0.328

High

1367863

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

0

High-throughput

0.328

High

352788

F107A
Actin-associated protein FAM107A

1

0

Small-scale

0.251

Low

260240

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

639790

TAF1
Transcription initiation factor TFIID subunit 1

1

0

High-throughput

0.249

Low

1155610

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1260588

B4GN4
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

1

0

Small-scale

0.238

Low

1367857

WAC
WW domain-containing adapter protein with coiled-coil

1

0

Small-scale

0.238

Low

1146594

TMED2
Transmembrane emp24 domain-containing protein 2

1

0

High-throughput

0.232

Low

1367855

F167A
Protein FAM167A

1

0

High-throughput

0.232

Low

1367867

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025