HitPredict

Interactor 1: BIN1 (O00499)
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)
Gene: BIN1

Interactor 2: BIN2 (Q9UBW5)
Bridging integrator 2 (Breast cancer-associated protein 1)
Gene: BIN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	28514442, 33961781, 10903846
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BAR~BAR
Common GO terms	GO:0005543 - phospholipid binding GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 565
+	Hs
		131220 BIN1_HUMAN (1-593): 1.03e-133: 404: 100.00		AMPH_HUMAN (6-560): 9.64e-90: 292: 33.10
+	Rn
		139967 BIN1_RAT (1-592): 2.1e-127: 388: 93.59		AMPH_RAT (6-547): 3.28e-91: 296: 30.57
+	Hs
		131173 BIN1_HUMAN (1-593): 1.03e-133: 404: 100.00		BIN1_HUMAN (1-476): 2.43e-78: 260: 36.99
+	Dm
		1180675 Q7KLE5_DROME (6-592): 6.45e-67: 230: 24.57		Q7KLE5_DROME (12-409): 4.2e-71: 241: 30.50
+	Hs
		827764 BIN2_HUMAN (13-517): 8.08e-46: 172: 33.66		AMPH_HUMAN (6-560): 9.64e-90: 292: 33.10
+	Rn
		139991 BIN1_RAT (1-592): 2.1e-127: 388: 93.59		SYNJ1_RAT (236-554): 6.25e-09: 61.2: 10.46
+	Hs
		1167804 DNMBP_HUMAN (17-591): 7.98e-54: 200: 16.93		DNMBP_HUMAN (16-506): 1.71e-61: 222: 17.01
+	Hs
		827728 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		AMPH_HUMAN (6-560): 9.64e-90: 292: 33.10
+	Ca
		1124012 RV161_CANAL (17-270): 5.06e-55: 189: 22.18		RV167_CANAL (15-397): 2.14e-58: 202: 17.00
+	Rn
		139966 AMPH_RAT (44-592): 1.56e-19: 94.9: 16.52		AMPH_RAT (6-547): 3.28e-91: 296: 30.57
+	Hs
		1167829 DNMBP_HUMAN (17-591): 7.98e-54: 200: 16.93		BIN3_HUMAN (31-265): 2.26e-52: 181: 19.67
+	Sc
		629628 RV161_YEAST (16-265): 9.32e-54: 185: 20.23		RV167_YEAST (15-354): 1.05e-51: 186: 16.93
+	Hs
		49920 BIN3_HUMAN (32-289): 1.84e-34: 132: 16.73		ARH37_HUMAN (17-415): 1.01e-56: 203: 14.83
+	Hs
		1052365 SRC8_HUMAN (14-591): 1.39e-77: 257: 16.72		CABIN_HUMAN (301-561): 4.29e-10: 65.1: 13.01
+	Dm
		112574 M9ND00_DROME (322-591): 2.06e-32: 135: 16.49		Q5U0V7_DROME (56-520): 1.16e-43: 169: 12.94
+	Hs
		203213 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		SYNJ1_HUMAN (183-563): 8.21e-11: 67.4: 14.43
+	Hs
		827768 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		CABIN_HUMAN (301-561): 4.29e-10: 65.1: 13.01