HitPredict

Interactor 1: STK25 (O00506)
Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)
Gene: STK25

Interactor 2: 2AAA (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: PPP2R1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	18782753, 35271311, 32707033, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HEAT~Pkinase, HEAT_2~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 426 Hs			1 589
+	Hs
		131550 STK25_HUMAN (1-426): 4.51e-156: 449: 100.00		2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40
+	Hs
		672377 STK24_HUMAN (8-424): 7.71e-143: 416: 71.12		2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00
+	Hs
		672332 STK26_HUMAN (15-420): 4.41e-138: 403: 67.32		2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00
+	Hs
		672501 STK24_HUMAN (8-424): 7.71e-143: 416: 71.12		2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40
+	Hs
		672006 AKT1_HUMAN (6-330): 4.86e-131: 387: 25.75		2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00
+	Hs
		672483 STK26_HUMAN (15-420): 4.41e-138: 403: 67.32		2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40
+	Dm
		734194 AKT1_DROME (13-334): 3.14e-131: 392: 24.47		2AAA_DROME (1-578): 2.84e-146: 436: 75.35
+	Dm
		734198 HIPPO_DROME (3-385): 3.61e-120: 366: 39.79		2AAA_DROME (1-578): 2.84e-146: 436: 75.35
+	Mm
		949335 TNIK_MOUSE (15-293): 4.43e-72: 248: 45.97		2AAA_MOUSE (1-589): 2.29e-166: 488: 99.83
+	Hs
		672343 TNIK_HUMAN (15-293): 6.7e-72: 247: 45.97		2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00
+	At
		1104817 CIPKJ_ARATH (4-426): 5.52e-131: 387: 18.86		2AAA_ARATH (92-587): 3.85e-48: 178: 17.74
+	At
		1103381 CIPK3_ARATH (18-418): 3.82e-131: 386: 20.75		2AAA_ARATH (92-587): 3.85e-48: 178: 17.74
+	Ce
		110178 GCK1_CAEEL (12-363): 7.26e-126: 380: 65.16		2AAA_CAEEL (92-589): 2.72e-42: 162: 18.85
+	Hs
		568748 KAPCA_HUMAN (4-322): 7.9e-132: 384: 22.32		GCN1_HUMAN (28-589): 5.37e-25: 112: 16.01
+	Hs
		1026197 PAK1_HUMAN (15-295): 7.61e-121: 363: 44.52		GCN1_HUMAN (28-589): 5.37e-25: 112: 16.01