Protein: TNFL6
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]

Gene: TNFL6, FASLG
Organism: Homo sapiens
Interactions: 113
UniProt ID: P48023

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005102 - signaling receptor binding
GO:0005123 - death receptor binding
GO:0005125 - cytokine activity
GO:0005164 - tumor necrosis factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

674964

TNR6
Tumor necrosis factor receptor superfamily member 6

7

20

Small-scale

0.965

High

336188

TNF6B
Tumor necrosis factor receptor superfamily member 6B

4

20

Small-scale

0.878

High

869483

CASP8
Caspase-8

7

13

Small-scale

0.739

High

622550

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

20

Small-scale

0.737

High

869507

SNX33
Sorting nexin-33

6

2

Small-scale

0.736

High

869480

FADD
FAS-associated death domain protein

6

16

Small-scale

0.726

High

593943

NCK1
SH2/SH3 adapter protein NCK1

4

15

Small-scale

0.697

High

869530

SNX9
Sorting nexin-9

4

2

Small-scale

0.694

High

440439

FYN
Tyrosine-protein kinase Fyn

4

12

Small-scale

0.692

High

869529

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

3

7

Small-scale

0.675

High

869517

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

3

1

High-throughput

0.667

High

869470

ANM2
Protein arginine N-methyltransferase 2

4

0

High-throughput

0.661

High

869504

MSPD2
Motile sperm domain-containing protein 2

4

0

High-throughput

0.661

High

222030

NCK2
Cytoplasmic protein NCK2

3

17

Small-scale

0.658

High

238804

KALRN
Kalirin

1

1

Small-scale

0.647

High

389145

FINC
Fibronectin

1

1

Small-scale

0.647

High

869467

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

8

Small-scale

0.647

High

303113

RGS20
Regulator of G-protein signaling 20

3

0

High-throughput

0.646

High

869515

FNBP1
Formin-binding protein 1

2

10

Small-scale

0.641

High

869501

P3H3
Prolyl 3-hydroxylase 3

4

1

High-throughput

0.630

High

869474

GRB2
Growth factor receptor-bound protein 2

2

14

Small-scale

0.629

High

463399

LYN
Tyrosine-protein kinase Lyn

2

12

Small-scale

0.613

High

220751

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

2

8

Small-scale

0.612

High

869519

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

2

9

Small-scale

0.612

High

869527

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

2

8

Small-scale

0.612

High

869482

KT33B
Keratin, type I cuticular Ha3-II

2

5

High-throughput

0.606

High

869484

SC23A
Protein transport protein Sec23A

2

1

High-throughput

0.606

High

869514

SNX18
Sorting nexin-18

2

2

Small-scale

0.601

High

269528

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

2

3

Small-scale

0.595

High

869523

ITSN2
Intersectin-2

2

1

Small-scale

0.594

High

70139

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

869488

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.580

High

869492

TENS2
Tensin-2

2

0

High-throughput

0.580

High

869477

ITK
Tyrosine-protein kinase ITK/TSK

1

12

Small-scale

0.578

High

163259

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

20

Small-scale

0.575

High

869497

NT2NA
Notch homolog 2 N-terminal-like protein A

1

2

High-throughput

0.573

High

582709

EZRI
Ezrin

2

1

Small-scale

0.571

High

869509

CASPA
Caspase-10

2

13

Small-scale

0.571

High

869486

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.549

High

869485

CIP4
Cdc42-interacting protein 4

1

11

Small-scale

0.534

High

463020

YES
Tyrosine-protein kinase Yes

1

12

Small-scale

0.527

High

473381

HCK
Tyrosine-protein kinase HCK

1

12

Small-scale

0.527

High

557173

SRC
Proto-oncogene tyrosine-protein kinase Src

1

12

Small-scale

0.527

High

869510

OSTF1
Osteoclast-stimulating factor 1

1

6

Small-scale

0.527

High

869493

K1C40
Keratin, type I cytoskeletal 40

1

4

High-throughput

0.523

High

869508

SC65
Endoplasmic reticulum protein SC65

2

1

High-throughput

0.521

High

869498

TMC6
Transmembrane channel-like protein 6

1

0

High-throughput

0.513

High

66395

RIM3C
RIMS-binding protein 3C

1

1

Small-scale

0.501

High

131549

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

1

1

Small-scale

0.501

High

178082

FYB1
FYN-binding protein 1

1

1

Small-scale

0.501

High

212758

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

3

Small-scale

0.501

High

250222

VINEX
Vinexin

1

4

Small-scale

0.501

High

286763

SKAP2
Src kinase-associated phosphoprotein 2

1

3

Small-scale

0.501

High

292817

GRAP2
GRB2-related adapter protein 2

1

14

Small-scale

0.501

High

325376

ZO3
Tight junction protein ZO-3

1

1

Small-scale

0.501

High

386446

SPTA1
Spectrin alpha chain, erythrocytic 1

1

1

Small-scale

0.501

High

439992

LCK
Tyrosine-protein kinase Lck

1

12

Small-scale

0.501

High

480375

MMP7
Matrilysin

1

1

Small-scale

0.501

High

486669

FGR
Tyrosine-protein kinase Fgr

1

12

Small-scale

0.501

High

572789

NCF1
Neutrophil cytosol factor 1

1

8

Small-scale

0.501

High

699645

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

Small-scale

0.501

High

840867

TEC
Tyrosine-protein kinase Tec

1

12

Small-scale

0.501

High

855554

CRK
Adapter molecule crk

1

7

Small-scale

0.501

High

869476

BTK
Tyrosine-protein kinase BTK

1

12

Small-scale

0.501

High

869479

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

2

Small-scale

0.501

High

869481

GRAP
GRB2-related adapter protein

1

14

Small-scale

0.501

High

869487

DLG2
Disks large homolog 2

1

1

Small-scale

0.501

High

869505

ES8L3
Epidermal growth factor receptor kinase substrate 8-like protein 3

1

11

Small-scale

0.501

High

869506

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

7

Small-scale

0.501

High

869513

MPP4
MAGUK p55 subfamily member 4

1

1

Small-scale

0.501

High

869516

SH3G3
Endophilin-A3

1

5

Small-scale

0.501

High

869518

RHG09
Rho GTPase-activating protein 9

1

3

Small-scale

0.501

High

869520

SAMN1
SAM domain-containing protein SAMSN-1

1

1

Small-scale

0.501

High

869525

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

7

Small-scale

0.501

High

869526

MYO15
Unconventional myosin-XV

1

3

Small-scale

0.501

High

869499

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

1

3

Small-scale

0.481

High

869489

MIA
Melanoma-derived growth regulatory protein

1

0

Small-scale

0.480

High

869496

MACC1
Metastasis-associated in colon cancer protein 1

1

0

Small-scale

0.480

High

869503

DOCK4
Dedicator of cytokinesis protein 4

1

0

Small-scale

0.480

High

869524

SPN90
NCK-interacting protein with SH3 domain

1

0

Small-scale

0.480

High

192996

CFLAR
CASP8 and FADD-like apoptosis regulator

1

13

Small-scale

0.479

High

612926

EGR1
Early growth response protein 1

1

5

High-throughput

0.479

High

869478

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.479

High

51590

SPD2B
SH3 and PX domain-containing protein 2B

1

10

Small-scale

0.457

High

869469

CACB3
Voltage-dependent L-type calcium channel subunit beta-3

1

1

Small-scale

0.457

High

869491

SPD2A
SH3 and PX domain-containing protein 2A

1

8

Small-scale

0.457

High

869495

DNMBP
Dynamin-binding protein

1

3

Small-scale

0.457

High

683796

MOES
Moesin

1

1

Small-scale

0.445

High

839200

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.445

High

869471

BID
BH3-interacting domain death agonist

1

1

Small-scale

0.445

High

869473

RHOA
Transforming protein RhoA

1

1

Small-scale

0.445

High

869522

MDN1
Midasin

1

1

High-throughput

0.445

High

869475

RHG04
Rho GTPase-activating protein 4

1

3

Small-scale

0.437

High

220576

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.426

High

248569

FADS1
Acyl-CoA

1

0

High-throughput

0.426

High

853620

MK08
Mitogen-activated protein kinase 8

1

0

Small-scale

0.426

High

869468

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

Small-scale

0.426

High

869511

INT12
Integrator complex subunit 12

1

0

High-throughput

0.426

High

3272

A0A0S2Z4D7
NCK adaptor protein 1 isoform 2

1

17

High-throughput

0.417

High

869494

SCAR3
Scavenger receptor class A member 3

1

1

High-throughput

0.407

High

869512

RUSF1
RUS family member 1

1

1

High-throughput

0.407

High

869528

KDIS
Kinase D-interacting substrate of 220 kDa

1

1

High-throughput

0.407

High

838965

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

Small-scale

0.391

High

869472

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

869500

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

869502

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.316

High

289851

TIPRL
TIP41-like protein

1

0

High-throughput

0.279

Low

301863

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.249

Low

60305

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.232

Low

869490

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.232

Low

869521

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

869531

PEX16
Peroxisomal membrane protein PEX16

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025