HitPredict

Interactor 1: KRIT1 (O00522)
Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)
Gene: KRIT1

Interactor 2: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0007264 - small GTPase-mediated signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 193
+	Hs
		131824 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		131829 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		131816 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12
+	Hs
		131827 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		131820 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54
+	Hs
		900423 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		925238 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		950953 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92
+	Hs
		893947 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		915638 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		925204 ANK2_HUMAN (5-374): 4.24e-78: 276: 12.53		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		719441 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		719446 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92
+	Hs
		719433 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		545233 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12
+	Hs
		719438 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		719431 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54
+	Hs
		276162 PSD10_HUMAN (278-419): 6.29e-39: 145: 30.07		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		883465 RIPK4_HUMAN (279-639): 1.08e-28: 124: 12.70		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		900896 Q9H4D1_HUMAN (279-639): 2.22e-28: 123: 12.70		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71