HitPredict

Interactor 1: KRIT1 (O00522)
Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)
Gene: KRIT1

Interactor 2: RAP1B (P61224)
Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Gene: RAP1B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22577140
Identification Methods	x-ray crystallography
Interaction Type	association

Property	Details
Interacting Pfam domains	FERM_M~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:2000114 - regulation of establishment of cell polarity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 184
+	Hs
		131826 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RB11A_HUMAN (4-178): 2.05e-69: 211: 28.98
+	Hs
		131828 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAP1A_HUMAN (1-184): 2.59e-69: 210: 95.11
+	Hs
		131829 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAC1_HUMAN (1-184): 1.05e-68: 209: 27.55
+	Hs
		131814 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RASK_HUMAN (1-167): 6.26e-55: 174: 57.49
+	Hs
		925238 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RAC1_HUMAN (1-184): 1.05e-68: 209: 27.55
+	Hs
		350123 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RASK_HUMAN (1-167): 6.26e-55: 174: 57.49
+	Hs
		925204 ANK2_HUMAN (5-374): 4.24e-78: 276: 12.53		RAC1_HUMAN (1-184): 1.05e-68: 209: 27.55
+	Hs
		349253 ANK2_HUMAN (5-374): 4.24e-78: 276: 12.53		RASH_HUMAN (1-167): 1.22e-55: 175: 57.49
+	Hs
		350083 ANK2_HUMAN (5-374): 4.24e-78: 276: 12.53		RASK_HUMAN (1-167): 6.26e-55: 174: 57.49
+	Hs
		350675 ANR50_HUMAN (19-383): 1.18e-70: 254: 10.29		RASK_HUMAN (1-167): 6.26e-55: 174: 57.49
+	Hs
		349001 ANR50_HUMAN (19-383): 1.18e-70: 254: 10.29		RASN_HUMAN (1-167): 5.03e-54: 171: 56.89
+	Hs
		719441 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RAC1_HUMAN (1-184): 1.05e-68: 209: 27.55
+	Hs
		719572 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RIT1_HUMAN (2-180): 7.98e-57: 179: 49.16
+	Hs
		349155 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RASH_HUMAN (1-167): 1.22e-55: 175: 57.49
+	Hs
		349925 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RASK_HUMAN (1-167): 6.26e-55: 174: 57.49
+	Hs
		348539 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RASN_HUMAN (1-167): 5.03e-54: 171: 56.89
+	Hs
		349416 ANR11_HUMAN (257-404): 5.64e-29: 126: 26.85		RASH_HUMAN (1-167): 1.22e-55: 175: 57.49
+	Hs
		925476 CSKI2_HUMAN (273-457): 9.9e-14: 77.1: 23.32		RAC1_HUMAN (1-184): 1.05e-68: 209: 27.55
+	Hs
		349533 CSKI2_HUMAN (273-457): 9.9e-14: 77.1: 23.32		RASH_HUMAN (1-167): 1.22e-55: 175: 57.49
+	Hs
		350402 CSKI2_HUMAN (273-457): 9.9e-14: 77.1: 23.32		RASK_HUMAN (1-167): 6.26e-55: 174: 57.49