HitPredict

Interactor 1: KRIT1 (O00522)
Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)
Gene: KRIT1

Interactor 2: RAP1A (P62834)
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Gene: RAP1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	9285558
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FERM_M~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 184
+	Hs
		131823 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11
+	Hs
		131829 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08
+	Hs
		131826 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RB11A_HUMAN (4-178): 2.1e-71: 216: 28.41
+	Hs
		131814 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RASK_HUMAN (1-184): 8.24e-56: 176: 54.45
+	Hs
		925238 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08
+	Mm
		71299 ANR44_MOUSE (5-652): 3.26e-83: 286: 11.33		RAB13_MOUSE (4-183): 6.71e-76: 227: 33.85
+	Hs
		925204 ANK2_HUMAN (5-374): 4.24e-78: 276: 12.53		RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08
+	Hs
		350123 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RASK_HUMAN (1-184): 8.24e-56: 176: 54.45
+	Hs
		350083 ANK2_HUMAN (5-374): 4.24e-78: 276: 12.53		RASK_HUMAN (1-184): 8.24e-56: 176: 54.45
+	Hs
		349253 ANK2_HUMAN (5-374): 4.24e-78: 276: 12.53		RASH_HUMAN (1-180): 7.38e-55: 173: 55.00
+	Hs
		350675 ANR50_HUMAN (19-383): 1.18e-70: 254: 10.29		RASK_HUMAN (1-184): 8.24e-56: 176: 54.45
+	Hs
		719441 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08
+	Hs
		719572 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RIT1_HUMAN (2-180): 2.98e-56: 178: 48.37
+	Hs
		349925 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RASK_HUMAN (1-184): 8.24e-56: 176: 54.45
+	Hs
		349155 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RASH_HUMAN (1-180): 7.38e-55: 173: 55.00
+	Dm
		1248518 Q8SWY2_DROME (5-307): 5.46e-37: 151: 10.20		Q962I2_DROME (4-184): 1.44e-54: 173: 49.20
+	Hs
		349416 ANR11_HUMAN (257-404): 5.64e-29: 126: 26.85		RASH_HUMAN (1-180): 7.38e-55: 173: 55.00
+	Hs
		925476 CSKI2_HUMAN (273-457): 9.9e-14: 77.1: 23.32		RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08
+	Hs
		350402 CSKI2_HUMAN (273-457): 9.9e-14: 77.1: 23.32		RASK_HUMAN (1-184): 8.24e-56: 176: 54.45
+	Hs
		349533 CSKI2_HUMAN (273-457): 9.9e-14: 77.1: 23.32		RASH_HUMAN (1-180): 7.38e-55: 173: 55.00